49ers vs. Cardinals Predictions & Best Bets: Spread, Moneyline, Over/Under and Props | Week 15

Written By PlayPicks Staff on December 16, 2023

The Arizona Cardinals (3-10) host a streaking San Francisco 49ers (10-3) team on Sunday, December 17, 2023 at State Farm Stadium (with best bets available). The 49ers have won five straight games.

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Spread: 49ers (-12.5) to Cover

  • The 49ers are the bet in this contest. They’re favored by 6.2 more points in the model than DraftKings (18.7 to 12.5).
  • San Francisco’s ATS record is 7-6-0 this season.
  • As a 12.5-point favorite or greater, the 49ers have one win ATS (1-2) this season.
  • San Francisco is 2-1 against the spread and 3-0 overall in its last three matchups.
  • Arizona has covered the spread seven times over 13 games with a set total.
  • The Cardinals have not covered the spread when an underdog by 12.5 points or more this year (in two opportunities).
  • Arizona has covered the spread twice in its past three contests while putting up a 3-0 record straight-up in those games.

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Total: Under 48.5

  • In this matchup, the model projects a total (44.1 points) marginally lower than the DraftKings over/under (48.5 points).
  • Arizona has played in five games this season where they combined with their opponents to score more than 48.5 points.
  • 49ers games have gone over the point total six out of 13 times this season.
  • In 2023, seven Cardinals games have hit the over.

Will this matchup go under the total? Check out DraftKings Sportsbook for the latest odds and to get the best signup offer using our link!

Moneyline Winner: 49ers (-850)

  • Prediction:
    San Francisco 31 – Arizona 13
  • San Francisco has put together a 10-3 record in games they were favored on the moneyline (winning 76.9% of those games).
  • This season, Arizona has been the underdog 13 times and won three, or 23.1%, of those games.

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49ers and Cardinals Splits

49ers Cardinals
Record 10-3 3-10
At Home 5-1 2-4
On the Road 5-2 1-6
In Conference 8-1 2-6
In Division 4-0 0-4
One Possession Games 1-2 1-4
Indoor 0-1 2-5
Outdoor 10-2 1-5

Want more information about this game? Take a look at the full preview here!

Kyler Murray Passing TDs: Over 0.5 (-238)

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Christian McCaffrey Rushing Yards: Under 85.5 (-115)

  • 2023 Season: 226 CAR / 1,177 YDS / 90.5 YPG / 12 TD
  • In 49ers’ Last 5 Games: 89 CAR / 525 YDS / 105 YPG / 3 TD
  • In 49ers’ Last 3 Games: 89 CAR / 525 YDS / 105 YPG / 3 TD
  • Sunday’s rushing yards over/under for McCaffrey is set at 85.5. That’s five fewer yards than his season average of 90.5.
  • McCaffrey has hit the rushing yards over in four of five opportunities (80.0%).

Check out all of McCaffrey’s props for this matchup and sign up to place your bets with DraftKings Sportsbook.

Brandon Aiyuk Receiving Yards: Under 70.5 (-115)

  • 2023 Season: 56 REC / 1,053 YDS / 87.8 YPG / 6 TD
  • In 49ers’ Last 5 Games: 21 REC / 433 YDS / 86.6 YPG / 4 TD
  • In 49ers’ Last 3 Games: 13 REC / 222 YDS / 74 YPG / 2 TD
  • Aiyuk is averaging 87.8 receiving yards per game, 17.3 more than the over/under of 70.5 set for Sunday’s outing.
  • Aiyuk has hit the over on his prop bets for receiving yards two times in five games this year (40.0%).

Explore all of Aiyuk’s props for this matchup and sign up to place your bets with DraftKings Sportsbook.

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