Count on plenty of points from the San Francisco 49ers (10-3) when they visit the Arizona Cardinals (3-10) at State Farm Stadium on December 17 at 4:05 PM ET. The 49ers are owners of the league’s third-ranked scoring offense, while the Cardinals own the 30th-ranked defense.
The Cardinals are big, 12-point underdogs against the 49ers (the game has a total of 48 points).
The betting facts in the article below reference odds valid as of December 17, 2023 at 4:11 PM ET. Head to the article below for the latest lines for this matchup and click here to get the best DraftKings Sportsbook deposit bonus!
49ers Vs Cardinals Odds
| Favorite | Spread | Over/Under |
|---|---|---|
| 49ers | -12 | 48 |
49ers vs. Cardinals Predictions
| ATS pick | Over/Under pick |
|---|---|
| 49ers (-12) | Under (48) |
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Team Stat Rankings
| 49ers | Cardinals | |
|---|---|---|
| Off. Points per Game (Rank) | 29.2 (4) | 17.7 (27) |
| Def. Points per Game (Rank) | 15.8 (1) | 25.5 (26) |
| Off. Yards per Play (Rank) | 6.7 (1) | 4.8 (26) |
| Def. Yards per Play (Rank) | 4.9 (5) | 5.5 (24) |
| Turnovers Allowed (Rank) | 12 (3) | 15 (8) |
| Turnovers Forced (Rank) | 23 (4) | 15 (22) |
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49ers Betting Insights
- Against the spread, the 49ers are 7-6-0 this season.
- As a 12-point or greater favorite, San Francisco has one win ATS (1-2) this season.
- There have been six 49ers games (out of 13) that went over the total this year.
- San Francisco games this season have posted an average total of 43.4, which is 4.6 points fewer than the total for this matchup.
Cardinals Betting Insights
- The Cardinals have covered the spread seven times in 13 games.
- Arizona is winless ATS (0-2) when playing as at least 12-point underdogs this year.
- Out of 13 Cardinals games so far this year, seven have hit the over.
- Arizona’s games have finished with more than 48 points six times this season.
- Cardinals games average 43.3 total points, 4.7 fewer than the total for this matchup.
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49ers Players to Watch
- The team’s top rusher, Christian McCaffrey, has carried the ball 226 times for 1,177 yards (90.5 per game), scoring 12 times. He’s also caught 52 passes for 437 yards and five touchdowns.
- This season, Deebo Samuel has carried the ball 30 times for 161 yards (14.6 per game) and five touchdowns, while also racking up 739 yards through the air with four touchdowns.
- Brandon Aiyuk has hauled in 56 receptions for 1,053 yards (87.8 yards per game) to lead the team this season. He’s found the end zone six times as a receiver.
- George Kittle has caught 53 passes for 811 yards (62.4 yards per game) and six touchdowns this year.
- Nick Bosa has collected 9.0 sacks to pace the team, while also picking up 11.0 TFL and 45 tackles.
- Fred Warner has been all over the field, leading the team in both tackles and interceptions. He has 108 tackles, 5.0 TFL, 2.5 sacks, and four interceptions.
Cardinals Players to Watch
- The team’s top rusher, James Conner, has carried the ball 129 times for 631 yards (70.1 per game) with four touchdowns.
- Emari Demercado has rushed for 210 yards on 52 carries with one touchdown.
- Trey McBride has hauled in 610 receiving yards on 56 catches to pace his squad this season while scoring two touchdowns as a receiver.
- Marquise Brown has 51 receptions (on 101 targets) for a total of 574 yards (44.2 yards per game) and four touchdowns this year.
- Michael Wilson has racked up 435 reciving yards (48.3 ypg) and two touchdowns this season.
- Dennis Gardeck has racked up 5.0 sacks to lead the team, while also recording 7.0 TFL and 34 tackles.
- Jalen Thompson has 62 tackles, 4.0 TFL, 1.0 sack, and three interceptions, and leads the team in both tackles and interceptions.
How to Bet on 49ers vs Cardinals
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