Bills vs. Chargers Predictions, Betting Trends and Stats – Week 16

Written By PlayPicks Staff on December 19, 2023 - Last Updated on September 25, 2024

When the Buffalo Bills (8-6) and the Los Angeles Chargers (5-9) square off on Saturday, December 23 at 8:00 PM ET, the Bills will be aiming to follow up their recent victory over the Cowboys with another win, and the Chargers will be attempting to bounce back from a loss to the Raiders.

The Bills are favored by double-digits (10.5 points) over the Chargers. The total is set at 42.5 points.

The betting facts in this article are based off odds valid as of December 19, 2023 at 12:11 AM ET. Head to the article below for the latest lines for this contest and click here to get the best DraftKings Sportsbook deposit bonus!

Bills Vs Chargers Odds

Favorite Spread Over/Under
Bills -10.5 42.5

Bills vs. Chargers Predictions

Computer picks for Bills vs Chargers
ATS pick Over/Under pick
Chargers (+10.5) Over (42.5)

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Team Stat Rankings

Bills Chargers
Off. Points per Game (Rank) 27.1 (6) 21.6 (17)
Def. Points per Game (Rank) 18.1 (4) 24.6 (28)
Off. Yards per Play (Rank) 5.7 (5) 5.2 (14)
Def. Yards per Play (Rank) 5.2 (13) 5.6 (25)
Turnovers Allowed (Rank) 21 (22) 19 (16)
Turnovers Forced (Rank) 24 (3) 17 (20)

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Bills Betting Insights

  • The Bills have covered the spread six times in 14 games.
  • Buffalo has yet to win ATS (0-1) when playing as at least 10.5-point favorites this season.
  • Out of 14 Bills games so far this season, four have hit the over.
  • Buffalo games average 46.5 total points per game this season (postseason included), 4.0 greater than the over/under for this matchup.

Chargers Betting Insights

  • The Chargers’ record against the spread is 4-9-1.
  • This year, four of the Chargers’ 14 games have hit the over.
  • Los Angeles games have gone over 42.5 points on eight occasions this season.
  • The average total for Chargers games is 46.0 points, 3.5 more than this game’s over/under.

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Bills Players to Watch

  • The team’s top rusher, James Cook, has carried the ball 188 times for 968 yards (69.1 per game), scoring two times. He’s also caught 40 passes for 433 yards and four touchdowns.
  • Josh Allen has carried the ball 80 times for 398 yards (28.4 per game) and 11 touchdowns.
  • Stefon Diggs has hauled in 91 catches for 1,041 yards (74.4 yards per game) to lead the team this season. He’s found the end zone eight times as a receiver.
  • Gabriel Davis has caught 39 passes for 595 yards (42.5 yards per game) and six touchdowns this year.
  • Dalton Kincaid’s 61 receptions have yielded 495 yards and two touchdowns.
  • Leonard Floyd has collected 10.5 sacks to pace the team, while also picking up 8.0 TFL and 27 tackles.
  • Terrel Bernard has been all over the field, leading the team in both tackles and interceptions. He has 117 tackles, 6.0 TFL, 3.5 sacks, and three interceptions.

Chargers Players to Watch

  • The team’s top rusher, Austin Ekeler, has carried the ball 141 times for 506 yards (46.0 per game), with five touchdowns this year. He’s proven to be a dual threat, hauling in 373 receiving yards (33.9 per game) on 40 catches with one receiving touchdown.
  • Joshua Kelley has compiled 404 yards on 102 carries with two touchdowns.
  • Keenan Allen’s 1,243 receiving yards (95.6 yards per game) are best on his team. He has 108 receptions on 150 targets with seven touchdowns.
  • Josh Palmer has 27 receptions (on 43 targets) for a total of 490 yards (61.3 yards per game) and two touchdowns this year.
  • Khalil Mack leads the team with 15.0 sacks, and also has 15.0 TFL and 58 tackles.
  • Los Angeles’ tackle leader, Kenneth Murray, has 103 tackles, 7.0 TFL, 3.0 sacks, and one interception this year.
  • Asante Samuel Jr. has a team-leading two interceptions to go along with 55 tackles, 1.0 TFL, and 12 passes defended.

How to Bet on Bills vs Chargers

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