49ers vs. Rams Predictions & Best Bets: Spread, Moneyline, Over/Under and Props | Week 2

Written By PlayPicks Staff on September 16, 2023

The San Francisco 49ers (1-0) face a fellow NFC West foe when they visit the Los Angeles Rams (1-0) on Sunday, September 17, 2023 at SoFi Stadium, and if you’re looking for best bets, we have them.

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Spread: Rams (+7.5) to Cover

  • The model line and the DraftKings line are within 0.4 points of each other.
  • Los Angeles compiled a 6-9-2 ATS record last year.
  • The Rams did not cover the spread when an underdog by 7.5 points or more last year (in two opportunities).
  • San Francisco compiled an 11-6-0 ATS record last year.
  • The 49ers were favored by 7.5 points or more seven times last season, and covered the spread in five of those contests.

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Total: Under 45

  • The model projects a total five points lower than the one set by DraftKings for this matchup.
  • San Francisco games had more than 45 points scored on nine occasions last year.
  • Los Angeles games had over 45 points five times last year.
  • Last season, the combined scoring went over the point total nine times in 49ers games.
  • The Rams and their opponent combined to hit the over six out of 17 times last season.

Will this matchup go under the total? Check out DraftKings Sportsbook for the latest odds and to get the best signup offer using our link!

Moneyline Winner: 49ers (-325)

  • Prediction:
    San Francisco 24 – Los Angeles 16
  • San Francisco has been the moneyline favorite only one other time so far this season, a game they won.
  • Los Angeles won the only game it has played as the underdog this season.

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49ers and Rams Splits

49ers (2022) Rams (2022)
Record 13-4 5-12
At Home 8-1 4-5
On the Road 5-3 1-7
In Conference 10-2 3-9
In Division 6-0 1-5
One Possession Games 3-1 3-4
Indoor 0-1 1-1
Outdoor 13-3 4-11

Interested in more information about this game? Take a look at the full preview here!

Matthew Stafford Passing TDs: Under 1.5 (-220)

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Christian McCaffrey Rushing Yards: Under 69.5 (-115)

  • 2023 Season: 22 CAR / 152 YDS / 152 YPG / 1 TD
  • In 49ers’ Last 5 Games: 22 CAR / 152 YDS / 152 YPG / 1 TD
  • In 49ers’ Last 3 Games: 22 CAR / 152 YDS / 152 YPG / 1 TD

See all of McCaffrey’s props for this matchup and sign up to place your bets with DraftKings Sportsbook.

McCaffrey Receiving Yards: Under 29.5 (-115)

  • 2023 Season: 3 REC / 17 YDS / 17 YPG / 0 TD
  • In 49ers’ Last 5 Games: 3 REC / 17 YDS / 17 YPG / 0 TD
  • In 49ers’ Last 3 Games: 3 REC / 17 YDS / 17 YPG / 0 TD

See all of McCaffrey’s props for this game and sign up to place your bets with DraftKings Sportsbook.

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