When the San Francisco 49ers (1-0) and the Los Angeles Rams (1-0) go head to head on Sunday, September 17 at 4:05 PM ET, they will both be aiming to stay on track after winning their last tilt. The 49ers won 30-7 versus the Steelers, and the Rams are coming off a 30-13 victory over the Seahawks.
The Rams are 7.5-point underdogs in their matchup with the 49ers (the game has an over/under of 45 points).
The betting facts in this article are based off odds valid as of September 17, 2023 at 11:15 AM ET. See below the latest odds for this matchup and click here to get the best DraftKings Sportsbook deposit bonus!
49ers Vs Rams Odds
| Favorite | Spread | Over/Under |
|---|---|---|
| 49ers | -7.5 | 45 |
49ers vs. Rams Predictions
| ATS pick | Over/Under pick |
|---|---|
| Rams (+7.5) | Under (45) |
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Team Stat Rankings (2022)
| 49ers | Rams | |
|---|---|---|
| Off. Points per Game (Rank) | 26.5 (6) | 18.1 (27) |
| Def. Points per Game (Rank) | 16.3 (1) | 22.6 (21) |
| Off. Yards per Play (Rank) | 5.9 (4) | 4.8 (29) |
| Def. Yards per Play (Rank) | 5 (3) | 5.5 (20) |
| Turnovers Allowed (Rank) | 17 (3) | 23 (17) |
| Turnovers Forced (Rank) | 30 (2) | 22 (17) |
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49ers Betting Insights
- The 49ers had 11 wins in 17 games against the spread last year.
- San Francisco’s ATS record as at least 7.5-point favorites was 5-2 last year.
- Out of 17 San Francisco games last year, nine hit the over.
- 49ers games had more than 45 points scored on nine occasions last season.
- San Francisco games last season posted an average total of 42.2, which is 2.8 points fewer than the total for this matchup.
Rams Betting Insights
- Rams posted a 6-9-2 record against the spread last season.
- Los Angeles didn’t have a win ATS (0-1-1) as 7.5-point or more underdogs last season.
- The Rams had six of their 17 games go over the point total last season.
- Los Angeles games had over 45 points five times last season.
- The over/under for this game is 2.8 points higher than the average scoring total for Rams games last season (42.2).
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49ers Players to Watch
- Brock Purdy had a passing stat line last season of 1,374 yards with a 67.1% completion rate (114-for-170), 13 touchdowns, four interceptions, and an average of 152.7 yards per game.
- Christian McCaffrey took 244 rushing attempts for 1,139 yards (67 per game) and scored eight touchdowns last season. When it comes to receiving, he caught 85 passes for 741 yards (43.6 per game) and five TDs.
- Elijah Mitchell collected 279 rushing yards on 45 carries and two touchdowns last season.
- Brandon Aiyuk collected 78 receptions for 1,015 yards and eight touchdowns last year. He was targeted 114 times, and averaged 59.7 yards per game.
- George Kittle also impressed receiving last year. He had 60 receptions for 765 yards and 11 touchdowns. He was targeted 86 times.
- Nick Bosa stacked up 18.5 sacks, 19 TFL and 51 tackles last season.
- Last season Fred Warner averaged 130 tackles, three TFL, two sacks, and one interception.
- Last season Tashaun Gipson had a huge stat line of five interceptions, 61 tackles, one TFL, 0.5 sacks, and eight passes defended.
Rams Players to Watch
- Matthew Stafford threw for 2,087 yards and 10 touchdowns last season.
- Cam Akers averaged 52.4 rushing yards per game and tallied seven rushing touchdowns.
- Kyren Williams rushed for 139 yards last season.
- Tyler Higbee was targeted 6.4 times per game and racked up 620 receiving yards and three touchdowns over the course of 2022.
- Demarcus Robinson caught 48 passes last season on his way to 458 yards and two receiving touchdowns.
- Ben Skowronek averaged 26.9 receiving yards per game on 4.4 targets per game a season ago.
- Last year Aaron Donald put pressure on opposing quarterbacks with five sacks, and added 10 TFL and 49 tackles.
- Ernest Jones had a stellar defensive performance last season with 113 tackles, four TFL, and one interception.
- Decobie Durant collected three interceptions in addition to 20 tackles, one TFL, one sack, and five passes defended a year ago.
How to Bet on 49ers vs Rams
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