The 1:00 PM ET game on October 15 between the San Francisco 49ers (5-0) and the Cleveland Browns (2-2) should be an exciting matchup, as Christian McCaffrey has been one of the league’s top runners this season, and the Browns have a top-five run defense, ranking fourth-best in the NFL at 71.8 rushing yards allowed per contest.
The 49ers are 9.5-point favorites in their matchup with the Browns. The over/under is 36 points.
The betting insights in what follows reflect odds as of October 15, 2023 at 11:15 AM ET. Keep scrolling for a look at all of the latest odds for this matchup and click here to get the best DraftKings Sportsbook deposit bonus!
49ers Vs Browns Odds
| Favorite | Spread | Over/Under |
|---|---|---|
| 49ers | -9.5 | 36 |
49ers vs. Browns Predictions
| ATS pick | Over/Under pick |
|---|---|
| 49ers (-9.5) | Over (36) |
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Team Stat Rankings
| 49ers | Browns | |
|---|---|---|
| Off. Points per Game (Rank) | 33.4 (2) | 19 (30) |
| Def. Points per Game (Rank) | 13.6 (2) | 15 (1) |
| Off. Yards per Play (Rank) | 6.3 (2) | 4.4 (27) |
| Def. Yards per Play (Rank) | 4.4 (3) | 3.8 (1) |
| Turnovers Allowed (Rank) | 2 (2) | 10 (27) |
| Turnovers Forced (Rank) | 9 (6) | 3 (28) |
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49ers Betting Insights
- Against the spread, the 49ers are 4-1-0 this year.
- San Francisco is unbeaten ATS (2-0) as a 9.5-point favorite or greater this year.
- The 49ers have played five games this year and three of them have hit the over.
- The average total for San Francisco games this season has been 43.8, 7.8 points higher than the total for this game.
Browns Betting Insights
- The Browns have posted two wins against the spread this season.
- One Browns game (out of four) has gone over the point total this year.
- Cleveland games have finished with over 36 points one time this year.
- This season, Browns games have resulted in an average scoring total of 41.1, which is 5.1 points higher than the over/under for this matchup.
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49ers Players to Watch
- The team’s top rusher, McCaffrey, has carried the ball 99 times for 510 yards (102 per game), scoring seven times. He’s also caught 20 passes for 168 yards and one touchdown.
- Jordan Mason has been handed the ball 16 times this year and racked up 90 yards (18 per game) with one touchdown.
- Brandon Aiyuk leads his squad with 378 yards as a receiver. He’s racked up that yardage on 21 catches (out of 27 targets) and scored two touchdowns.
- Deebo Samuel has caught 20 passes for 302 yards (60.4 yards per game) and one touchdown this year.
- George Kittle has compiled 17 receptions for 215 yards, an average of 43 yards per game. He’s scored three times as a receiver this season.
- Drake Jackson has three sacks to lead the team, and also has two TFL and six tackles.
- San Francisco’s top-tackler, Fred Warner, has 41 tackles, three TFL, two sacks, and one interception this year.
- Talanoa Hufanga has picked off a team-high two passes. He also has 17 tackles, one TFL, and two passes defended to his name.
Browns Players to Watch
- Jerome Ford is his team’s leading rusher with 50 carries for 186 yards, or 46.5 per game. He’s found paydirt one time on the ground, as well. Ford has also chipped in with 10 catches for 77 yards and two receiving touchdowns.
- Pierre Strong Jr. has piled up 77 yards (on 13 attempts) with one touchdown.
- Amari Cooper leads his squad with 259 receiving yards on 18 catches with one touchdown.
- Elijah Moore has put up a 148-yard season. He’s caught 17 passes on 29 targets.
- David Njoku has racked up 138 reciving yards (34.5 ypg) this season.
- Myles Garrett has collected 5.5 sacks to lead the team, while also recording five TFL and 10 tackles.
- So far Grant Delpit leads the team in both tackles and interceptions. He has totaled 21 tackles, one TFL, and one interception this season.
How to Bet on 49ers vs Browns
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