James Conner, who ranks fourth-best in the league in rushing yards, will aim to lead the charge for the Arizona Cardinals (1-2) on October 1 at 4:25 PM ET, when they visit the San Francisco 49ers (3-0) and their third-best run D (53.0 rushing yards allowed per game).
The 49ers are two-touchdown favorites against the Cardinals. The total is set at 43.5 points.
The betting insights in what follows are based off odds valid as of October 1, 2023 at 11:17 AM ET. Head to the article below for the latest lines for this game and click here to get the best DraftKings Sportsbook deposit bonus!
49ers Vs Cardinals Odds
| Favorite | Spread | Over/Under |
|---|---|---|
| 49ers | -14 | 43.5 |
49ers vs. Cardinals Predictions
| ATS pick | Over/Under pick |
|---|---|
| Cardinals (+14) | Over (43.5) |
Ready to put your picks to the test? Sign up for DraftKings Sportsbook and bet on this matchup today!
Team Stat Rankings
| 49ers | Cardinals | |
|---|---|---|
| Off. Points per Game (Rank) | 30.0 (5) | 24.0 (13) |
| Def. Points per Game (Rank) | 14.0 (5) | 22.3 (14) |
| Off. Yards per Play (Rank) | 6.0 (4) | 5.8 (5) |
| Def. Yards per Play (Rank) | 4.2 (3) | 5.3 (15) |
| Turnovers Allowed (Rank) | 1 (1) | 2 (5) |
| Turnovers Forced (Rank) | 5 (7) | 5 (7) |
Looking to build a lineup of players from the 49ers and Cardinals to try to win cash prizes? Sign up for DraftKings Daily Fantasy Sports and get an exclusive bonus using our link.
49ers Betting Insights
- The 49ers have two wins against the spread this season.
- One of the 49ers’ three games this season has hit the over.
- The over/under in this game is 43.5 points, 0.2 higher than the average total in San Francisco games this season (postseason included).
Cardinals Betting Insights
- Against the spread, the Cardinals are 3-0-0 this season.
- Two of the Cardinals’ three games in 2023 have gone over the point total.
- Arizona games have gone over 43.5 points scored twice this year.
- Cardinals games average 40.5 total points, 3.0 fewer than the total for this matchup.
Watch live NFL games, including the Super Bowl, On The Go with NFL+ for $12.99! Get a limited time offer on NFL+ for the rest of this season so you can watch live games on your mobile devices, catch up with NFL Network live on mobile, and get live audio of every game. Check out our link for this great offer for NFL+ just in time for the Super Bowl!
49ers Players to Watch
- Brock Purdy has thrown for 736 yards (245.3 ypg) to lead San Francisco, completing 67% of his passes and tossing four touchdown passes this season.
- The team’s top rusher, Christian McCaffrey, has carried the ball 60 times for 353 yards (117.7 per game), scoring three times. He’s also caught 11 passes for 70 yards.
- Elijah Mitchell has been handed the ball 16 times this year and racked up 52 yards (26.0 per game).
- Deebo Samuel’s team-high 247 yards as a receiver have come on 17 catches (out of 28 targets) with one touchdown.
- Brandon Aiyuk has caught 11 passes for 172 yards (86.0 yards per game) and two touchdowns this year.
- George Kittle has a total of 139 receiving yards this year, hauling in 13 throws.
- Drake Jackson has collected 3.0 sacks to pace the team, while also recording 2.0 TFL and five tackles.
- San Francisco’s top-tackler, Deommodore Lenoir, has 25 tackles and one interception this year.
- Talanoa Hufanga has picked off a team-leading two passes. He also has 11 tackles, 1.0 TFL, and two passes defended to his name.
Cardinals Players to Watch
- Joshua Dobbs has been a dual threat for Arizona this season. He has 549 passing yards (183.0 per game) while completing 72% of his passes. He’s thrown two touchdown passes and zero interceptions this season. On the ground, he’s compiled 93 yards (31.0 ypg) on 12 carries with one rushing touchdown.
- The team’s top rusher, Conner, has carried the ball 51 times for 266 yards (88.7 per game) with two touchdowns.
- Michael Wilson’s 161 receiving yards (53.7 yards per game) lead the team. He has seven receptions on nine targets.
- Marquise Brown has collected 143 receiving yards (47.7 yards per game) and two touchdowns on 14 receptions.
- Zach Ertz has racked up 83 reciving yards (27.7 ypg) this season.
- Dennis Gardeck has 3.0 sacks to pace the team, and also has 4.0 TFL and 10 tackles.
- Kyzir White has been all over the field, leading the team in both tackles and interceptions. He has 30 tackles, 3.0 TFL, 1.0 sack, and one interception.
How to Bet on 49ers vs Cardinals
If you’re looking for a place to bet on the 49ers or Cardinals, look no further than DraftKings Sportsbook, where you can use our link to get the best offer for new depositors!
Not all offers available in all states, please visit DraftKings for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.
