The San Francisco 49ers (2-0), who took down against the Rams in their previous contest, host the New York Giants (1-1) at Levi’s Stadium on September 21 at 8:15 PM ET. The Giants grabbed a win against the Cardinals in their last game.
The Giants are heavy, 10.5-point underdogs against the 49ers (the game has a total of 43.5 points).
The betting trends in what follows reference odds valid as of September 21, 2023 at 7:11 PM ET. Keep scrolling for a look at all of the latest odds for this matchup and click here to get the best DraftKings Sportsbook deposit bonus!
49ers Vs Giants Odds
| Favorite | Spread | Over/Under |
|---|---|---|
| 49ers | -10.5 | 43.5 |
49ers vs. Giants Predictions
| ATS pick | Over/Under pick |
|---|---|
| 49ers (-10.5) | Over (43.5) |
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Team Stat Rankings (2022)
| 49ers | Giants | |
|---|---|---|
| Off. Points per Game (Rank) | 26.5 (6) | 21.5 (15) |
| Def. Points per Game (Rank) | 16.3 (1) | 21.8 (17) |
| Off. Yards per Play (Rank) | 5.9 (4) | 5.2 (22) |
| Def. Yards per Play (Rank) | 5.0 (3) | 5.6 (24) |
| Turnovers Allowed (Rank) | 17 (3) | 16 (2) |
| Turnovers Forced (Rank) | 30 (2) | 19 (25) |
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49ers Betting Insights
- The 49ers were 11-6-0 against the spread last year.
- San Francisco did not lose ATS (1-0) as a 10.5-point or greater favorite last year.
- In 17 San Francisco games last season, nine went over the total.
- The 49ers and their opponent broke the 43.5-point mark nine times last year.
- The over/under for this game is 43.5 points, 1.3 more than the average point total for San Francisco games a year ago.
Giants Betting Insights
- The Giants covered the spread 13 times in 17 games last year.
- New York went unbeaten ATS (1-0) as underdogs of 10.5 points or greater last year.
- The Giants had seven of their 17 games go over the point total last year.
- New York games went over 43.5 points on nine occasions last season.
- The over/under for this game is 0.7 points higher than the average scoring total for Giants games last season (42.8).
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49ers Players to Watch
- Brock Purdy’s previous season stat line: 1,374 passing yards (152.7 per game), 114-for-170 (67.1%), 13 touchdowns and four picks.
- Last season Christian McCaffrey churned out 1,139 rushing yards (67.0 per game) and eight touchdowns. In the receiving game, he made 85 catches for 741 yards and five scores.
- Elijah Mitchell collected 279 rushing yards on 45 carries and two touchdowns last season.
- In the previous year, Brandon Aiyuk grabbed 78 passes (on 114 targets) for 1,015 yards (59.7 per game). He also found the end zone eight times.
- George Kittle also impressed receiving last season. He collected 60 receptions for 765 yards and 11 touchdowns. He was targeted 86 times.
- Nick Bosa’s hard work last season put up a stat line of 18.5 sacks, 19.0 TFL and 51 tackles.
- Fred Warner was a wrecking ball on the field, collecting 130 tackles, 3.0 TFL, 2.0 sacks, and one interception last year.
- Last season Tashaun Gipson had a huge stat line of five interceptions, 61 tackles, 1.0 TFL, 0.5 sacks, and eight passes defended.
Giants Players to Watch
- Daniel Jones averaged 200.3 passing yards per outing and completed 15 touchdowns last season. In addition, he added 708 yards rushing with seven touchdowns.
- Last season Matt Breida rushed for 220 yards. He also scored one total touchdown.
- Darius Slayton was targeted 4.4 times per game and piled up 724 receiving yards and two touchdowns over the course of 2022.
- Parris Campbell hauled in three touchdowns and had 623 receiving yards (36.6 ypg) in 2022.
- Isaiah Hodgins averaged 39.2 receiving yards per game on 4.8 targets per game a season ago.
- Last year Dexter Lawrence put pressure on opposing quarterbacks with 7.5 sacks, and added 7.0 TFL and 68 tackles.
- Bobby Okereke had an impactful defensive performance last season with 149 tackles and 6.0 TFL.
- A year ago Isaiah Simmons collected 99 tackles, 5.0 TFL, 4.0 sacks, and seven passes defended as well as two interceptions.
How to Bet on 49ers vs Giants
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