49ers vs. Giants Predictions, Betting Trends and Stats – Week 3

Written By PlayPicks Staff on September 19, 2023

The San Francisco 49ers (2-0), who took down against the Rams in their previous contest, host the New York Giants (1-1) at Levi’s Stadium on September 21 at 8:15 PM ET. The Giants grabbed a win against the Cardinals in their last game.

The Giants are heavy, 10.5-point underdogs against the 49ers (the game has a total of 43.5 points).

The betting trends in what follows reference odds valid as of September 21, 2023 at 7:11 PM ET. Keep scrolling for a look at all of the latest odds for this matchup and click here to get the best DraftKings Sportsbook deposit bonus!

49ers Vs Giants Odds

Favorite Spread Over/Under
49ers -10.5 43.5

49ers vs. Giants Predictions

Computer picks for 49ers vs Giants
ATS pick Over/Under pick
49ers (-10.5) Over (43.5)

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Team Stat Rankings (2022)

49ers Giants
Off. Points per Game (Rank) 26.5 (6) 21.5 (15)
Def. Points per Game (Rank) 16.3 (1) 21.8 (17)
Off. Yards per Play (Rank) 5.9 (4) 5.2 (22)
Def. Yards per Play (Rank) 5.0 (3) 5.6 (24)
Turnovers Allowed (Rank) 17 (3) 16 (2)
Turnovers Forced (Rank) 30 (2) 19 (25)

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49ers Betting Insights

  • The 49ers were 11-6-0 against the spread last year.
  • San Francisco did not lose ATS (1-0) as a 10.5-point or greater favorite last year.
  • In 17 San Francisco games last season, nine went over the total.
  • The 49ers and their opponent broke the 43.5-point mark nine times last year.
  • The over/under for this game is 43.5 points, 1.3 more than the average point total for San Francisco games a year ago.

Giants Betting Insights

  • The Giants covered the spread 13 times in 17 games last year.
  • New York went unbeaten ATS (1-0) as underdogs of 10.5 points or greater last year.
  • The Giants had seven of their 17 games go over the point total last year.
  • New York games went over 43.5 points on nine occasions last season.
  • The over/under for this game is 0.7 points higher than the average scoring total for Giants games last season (42.8).

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49ers Players to Watch

  • Brock Purdy’s previous season stat line: 1,374 passing yards (152.7 per game), 114-for-170 (67.1%), 13 touchdowns and four picks.
  • Last season Christian McCaffrey churned out 1,139 rushing yards (67.0 per game) and eight touchdowns. In the receiving game, he made 85 catches for 741 yards and five scores.
  • Elijah Mitchell collected 279 rushing yards on 45 carries and two touchdowns last season.
  • In the previous year, Brandon Aiyuk grabbed 78 passes (on 114 targets) for 1,015 yards (59.7 per game). He also found the end zone eight times.
  • George Kittle also impressed receiving last season. He collected 60 receptions for 765 yards and 11 touchdowns. He was targeted 86 times.
  • Nick Bosa’s hard work last season put up a stat line of 18.5 sacks, 19.0 TFL and 51 tackles.
  • Fred Warner was a wrecking ball on the field, collecting 130 tackles, 3.0 TFL, 2.0 sacks, and one interception last year.
  • Last season Tashaun Gipson had a huge stat line of five interceptions, 61 tackles, 1.0 TFL, 0.5 sacks, and eight passes defended.

Giants Players to Watch

  • Daniel Jones averaged 200.3 passing yards per outing and completed 15 touchdowns last season. In addition, he added 708 yards rushing with seven touchdowns.
  • Last season Matt Breida rushed for 220 yards. He also scored one total touchdown.
  • Darius Slayton was targeted 4.4 times per game and piled up 724 receiving yards and two touchdowns over the course of 2022.
  • Parris Campbell hauled in three touchdowns and had 623 receiving yards (36.6 ypg) in 2022.
  • Isaiah Hodgins averaged 39.2 receiving yards per game on 4.8 targets per game a season ago.
  • Last year Dexter Lawrence put pressure on opposing quarterbacks with 7.5 sacks, and added 7.0 TFL and 68 tackles.
  • Bobby Okereke had an impactful defensive performance last season with 149 tackles and 6.0 TFL.
  • A year ago Isaiah Simmons collected 99 tackles, 5.0 TFL, 4.0 sacks, and seven passes defended as well as two interceptions.

How to Bet on 49ers vs Giants

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