Giants vs. Guardians Prediction: MLB Betting Lines, Stats and Picks – September 12, 2023

Written By PlayPicks Staff on September 12, 2023

The San Francisco Giants (74-70) bring a four-game win streak into a home matchup versus the Cleveland Guardians (68-77) at 9:45 PM ET on Tuesday.

The Guardians are an underdog (+109 on the moneyline to win) when they square off against the Giants (-131). The contest has a set total of 8.5.

The betting trends in this article are based off odds valid as of September 12, 2023 at 9:13 PM ET. Ready to bet? Click here to get the best DraftKings Sportsbook deposit bonus!

Giants vs Guardians Betting Lines

Favorite Favorite Moneyline Underdog Moneyline Total
Giants -131 +109 8.5

Giants Betting Insights

  • The Giants have entered the game as favorites 73 times this season and won 41, or 56.2%, of those games.
  • San Francisco is 29-23 this season when entering a game favored by -131 or more on the moneyline.
  • The sportsbooks’ moneyline implies a 56.7% chance of a victory for the Giants.
  • Games involving San Francisco has gone over the total set by sportsbooks in 63 of 144 chances this season.
  • The Giants are 68-76-0 ATS in their 144 games with a spread this season.

Giants Last 10 Games Trend

Stat Avg/Total
Record 4-6
Runs Per Game 4.3
HR 14
ERA 5.19
K/9 7.4

Guardians Betting Insights

  • The Guardians have been underdogs in 74 games this season and have come away with the win 32 times (43.2%) in those contests.
  • Cleveland has a win-loss record of 19-31 when favored by +109 or worse by sportsbooks this year.
  • Oddsmakers have implied with the moneyline set for this matchup that the Guardians have a 47.8% chance of pulling out a win.
  • Contests with Cleveland has gone over the total set by bookmakers in 60 of 144 chances this season.
  • The Guardians are 74-70-0 against the spread in their 144 games that had a posted line this season.

Guardians Last 10 Games Trend

Stat Avg/Total
Record 3-7
Runs Per Game 3.5
HR 7
ERA 5.66
K/9 8.3

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Giants Probable Pitcher – Sean Manaea

  • Manaea’s team is 1-5-0 against the spread this season in his starts.
  • The left-hander’s last appearance came in relief on Wednesday when he threw three innings out of the bullpen against the Chicago Cubs, giving up two earned runs while allowing four hits.
  • Manaea has made three starts of five or more innings in six chances this season, and averages 2.8 frames when he pitches.
  • He has 11 appearances this season with zero earned runs allowed out of his 33 chances this season.
  • Manaea’s team has been upset in each of the three games he’s started as the moneyline favorite.
  • Manaea’s team has won one of his six starts this season.
  • The teams have hit the over in each of the six games Manaea has started this season.

Giants Relief Pitchers

Name Relief App. IP Ks ERA Holds Saves
Camilo Doval 62 61.2 81 2.92 0 37
Tyler Rogers 60 67.2 55 3.06 28 2
Taylor Rogers 55 49.1 59 3.1 12 1
Scott Alexander 42 44 28 4.7 6 1
Jakob Junis 32 80.2 90 4.02 2 1

Guardians Probable Pitcher – Cal Quantrill

  • Quantrill makes the start for the Guardians, his 16th of the season. He is 2-6 with a 5.70 ERA and 46 strikeouts in 79 2/3 innings pitched.
  • His most recent time out came on Friday against the Los Angeles Angels, when the righty went six scoreless innings while allowing three hits.
  • Quantrill will look to last five or more innings for his third straight appearance. He’s averaging 5.3 frames per outing.
  • He has had three appearances this season that he kept his opponents to zero earned runs.
  • The Guardians have been the moneyline underdog in nine of Quantrill’s starts this season, and they went 5-4 in those games.
  • Quantrill’s team has a 7-8 record in his starts this season.
  • Quantrill has started 15 contests with a total set by bookmakers this season. The teams have combined to go over the run total in five of them.

Guardians Relief Pitchers

Name Relief App. IP Ks ERA Holds Saves
Emmanuel Clase 66 65.2 58 3.15 0 39
Trevor Stephan 64 63 70 3.43 25 2
Enyel De Los Santos 62 58.2 56 3.37 15 0
Reynaldo López 58 59.2 75 3.62 16 6
Eli Morgan 54 59 63 3.2 8 1

Giants Hitting Trends

  • The Giants have a 30-19 record this season in games when they hit two or more homers.
  • San Francisco has had at least five extra-base hits in 25 games this season, and has gone 17-8 in those outings.
  • The team is 55-27 in the games this season it has strung together eight or more hits.
  • San Francisco is 45-18 in games this season when it scored at least five runs.
  • The Giants are 21-14 in games this season when they have drawn at least five walks.

Guardians Hitting Trends

  • They’ve hit two or more homers in 27 games this season and are 20-7 in those matchups.
  • Cleveland has gone 19-6 this season when collecting five or more extra-base hits as a team.
  • In 88 games this season with eight or more hits, they have a record of 46-42.
  • Cleveland has won 40 of its 53 games this season in which it scored more than four runs.
  • They have won 19 of their 36 games this season in which they’ve drawn more than four free passes.

Giants vs. Guardians Prediction

Moneyline Pick: Giants (-131)
Over/Under Pick: Over (8.5)

Predictions are calculated by a data-driven algorithm derived from offensive performance metrics and probable starting pitchers.

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