Week 12 NFL Betting Odds: Early Betting Lines, Preview For Every Matchup

Posted By Brian Sausa on July 30, 2021

Ever since the National Football League schedule was released back in May, the Week 12 slate was circled on the calendar. It’s late November, Thanksgiving is here, and we’ve got a unique NFL schedule compared to other weeks.

There are two teams on bye and 15 games in total, beginning with the Thursday slate on November 25. It’s a special holiday edition of NFL football with three games spread across the entire day. Eleven more contests will kick off on Sunday before the final game of the week on Monday Night Football. Let’s get a look at the NFL Week 12 betting odds from a range of online sportsbooks including some of the biggest names in the industry such as FanDuel, BetMGM, and DraftKings.

Week 12 NFL Betting Lines

Game MatchupOpening Line
Chicago Bears at Detroit LionsBears -3.5
Las Vegas Raiders at Dallas Cowboys Cowboys -5
Buffalo Bills at New Orleans SaintsBills -1.5
Tampa Bay Buccaneers at Indianapolis ColtsBuccaneers -1
New York Jets at Houston TexansJets -1
Philadelphia Eagles at New York GiantsGiants -3
Carolina Panthers at Miami Dolphins Dolphins -4.5
Tennessee Titans at New England PatriotsPatriots -1.5
Pittsburgh Steelers at Cincinnati BengalsSteelers -3
Atlanta Falcons at Jacksonville JaguarsJaguars -1
LA Chargers at Denver BroncosBroncos -2.5
LA Rams at Green Bay PackersRams -1
Minnesota Vikings at San Francisco 49ers49ers -6.5
Cleveland Browns at Baltimore RavensRavens -3.5
Seattle Seahawks at WashingtonSeahawks -2.5

NFL Week 12 matchups and predictions

Thursday, Nov. 25 (3 games)

Chicago Bears at Detroit Lions (+3.5) – 12:30 p.m.

Our Thanksgiving slate always begins in Detroit just past noon and this time around, it will be a divisional matchup with the Bears. These two have played 18 times on Turkey Day including in 2018 and 2019, which both resulted in close Chicago wins. We like that to happen again despite the Bears traveling on a short week, but we’d be willing to take a chance with Detroit at anything above 3.5 points. The group returns home for the first time in a month and will be galvanized by their lone national television presence of the year.

Las Vegas Raiders at Dallas Cowboys (-5) – 4:30 p.m.

The Raiders begin a stretch of three road games in four weeks when they travel to Dallas on Thanksgiving. The Cowboys opened as five-point favorites and have the advantage of playing at home, as they do every year on this day. These teams are similar in the sense that they want to score a ton of points, and also don’t excel on defense as currently built. We’d side toward Dallas in a back-and-forth game, but would like the over most.

Buffalo Bills at New Orleans Saints (+1.5) – 8:20 p.m.

In one of the most highly-anticipated games of the week, the Bills are traveling to the Superdome to take on the Saints in the Thanksgiving finale. New Orleans has an elite defense, but Buffalo has too many weapons not to put up some points in the dome. That means the pressure will be on Jameis Winston to match the scoring drives that Josh Allen will inevitably lead. In the end, anything less than a field goal means we’re going with Buffalo to grab a big road win. Winston will have to win some big games before we back him against a contender.

Sunday, Nov. 28 (1 p.m. ET)

Tampa Bay Buccaneers at Indianapolis Colts (+1)

The big-time matchups continue on Sunday as the defending champion Buccaneers visit the Indianapolis Colts as slim one-point favorites on the opening line. Decisions on games like this really depend on how you view the Colts’ offense with Carson Wentz and Frank Reich back together. Indy is building one of the league’s best rosters and we’re willing to bet this defense does enough to give Wentz and the offense a chance to win the game. Tampa Bay had some clunkers on the road occasionally in 2020, and it can happen again here.

New York Jets at Houston Texans (+1)

There aren’t too many games on the Jets schedule that appear they could be winnable from the jump, but this is one of them. Despite Gang Green being on the road in Week 12, a trip to Houston may be just what this team needs after hames against Indy, Buffalo, and Miami.

The Texans are rebuilding and have even more glaring holes than the Jets, who at least are formidable at a few positions. With no real spread to worry about on the opening line, the road team is the one to play while we still aren’t sure how Houston will look by this time exactly.

Philadelphia Eagles at New York Giants (-3)

The NFC heats up late in the season as the Eagles and Giants meet twice in the last two months, the first of those being in Week 12. Philadelphia was a brutal road team in 2020 but until this point in the season, hasn’t played too many tough games away from home. This will be the toughest one yet and with the additions that Big Blue will have on the offensive side, we like the favorite even with the opening line of -3.

Carolina Panthers at Miami Dolphins (-4.5)

On the surface, Miami seems to outmatch the Panthers in almost every facet of the game. The Dolphins are a deeper team with a strong defense and nobody really knows how the Sam Darnold project will go for the Carolina offense. That said, the Panthers’ defense manages to keep its team in games enough that we would consider a play on the road team getting the points. That is, unless Tua takes a massive leap early the season.

Tennessee Titans at New England Patriots (-1.5)

It wasn’t so long ago that Tennessee showed up to Foxboro and stunned the Patriots in the opening round of the playoffs. Both teams are very different now, and it will be interesting to see how things go in Week 12. The Titans no longer play defense, as this team wants to score and that’s really it. They should be able to do a bit of that with Derrick Henry and Julio Jones, but there’s no doubt the Patriots will do the same. Consider the over and if you’re brave enough, take Mike Vrabel to beat Bill Belichick.

Pittsburgh Steelers at Cincinnati Bengals (+3)

The Bengals-Steelers rivalry has been running hot for years now, so this is one of the most anticipated matchups of the season. The last time Pittsburgh visited, the Bengals dismantled them in prime time despite the fact that the Steelers had everything to play for. By this point in the season, we expect Joe Burrow to look how he did before his ACL injury, and that could spell bad news for the visitors. Give us the home team and anything more than three points, as Pittsburgh tends to not be the same team as road favorites.

Atlanta Falcons at Jacksonville Jaguars (-1)

There aren’t too many games in 2021 that feature the Jaguars as favorites on the opening line, but this is one of them. Exactly how these teams will look in late November is anyone’s guess, but this could be a spot for the visitors and the short line. Backing the Falcons against above-average teams is tough but Jacksonville’s defense is just bad enough that Matt Ryan could turn back the clock in this one.

Sunday, Nov. 28 (4:05 p.m. ET)

Los Angeles Chargers at Denver Broncos (-2.5)

After the Chiefs, it’s hard to tell exactly how the AFC West will turn out, but a lot of it will depend on how the Chargers and Broncos play against one another in Week 12, then again in Week. The first matchup is in Denver and the home team opened as 2.5-point favorites, and we like the fact that they’re coming off a bye and the Chargers are not. That said, Los Angeles is the superior overall team and is getting points in this one.

Sunday, Nov. 28 (4:25 p.m. ET)

Los Angeles Rams at Green Bay Packers (+1)

When the Rams visit the Packers at Lambeau Field, it will be the game everyone’s televisions are turned to. These two are going to be among the contenders in the NFC and this game could go a long way in determining home field advantage in a potential playoff game. The Rams have their missing piece in Matthew Stafford but we aren’t betting against Aaron Rodgers at Lambeau Field as it gets cold outside. Green Bay went 7-1 at home in 2020.

Minnesota Vikings at San Francisco 49ers (-6.5)

Two seasons ago, the 49ers completely shut down Dalvin Cook and the Vikings in the divisional round of the NFC playoffs. San Francisco is hoping to look more like the group that went to the Super Bowl after an injury-riddled 2020. Despite only covering one game at home last season, Minnesota has to prove it can go on the road and keep things close with a superior opponent. Instead, we’d look toward the over.

Sunday, Nov. 28 (8:20 p.m. ET)

Cleveland Browns at Baltimore Ravens (-3.5)

The AFC North in prime time is always must-watch TV for NFL fans, and it’s no different in Week 12. The Browns and Ravens gave us one of the most electrifying games of the season last December, a 47-42 Baltimore win. The home team opened at -3.5 and we’d expect to see some scoring once again, with the Ravens finding a way to win behind its defense since both teams have dynamic offenses.

Monday, Nov. 29 (8:15 p.m. ET)

Seattle Seahawks at Washington (+2.5)

The Week 12 schedule closes with an interesting matchup in the Landover, Maryland between the Seahawks and Washington Football Team. For whatever reason, Seattle is like Kansas City in that it wins a ton of games but doesn’t cover, at least on the road. With the number stuck on 2.5, that creates a bit of a conundrum for the bettor. It’s a pass for now and a look toward the under with Seattle’s offense stalling on the road and the WFT playing elite defense.

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Brian Sausa

Brian Sausa is a longtime sports writer with extensive betting experience and knowledge of the industry. A journalism graduate with an extensive sports background, Brian has been employed by multiple professional leagues including MLB, MiLB (Minor League Baseball), and the NHL.

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