Week 11 NFL Betting Odds: Early Betting Lines, Preview For Every Matchup

Posted By Brian Sausa on July 27, 2021 - Last Updated on July 30, 2021

If you’re one of the many National Football League bettors out there who like to check out the odds well in advance, then we’ve got a treat for you. Online sportsbooks posted NFL opening lines for every game throughout the season, and we’re going week by week to preview them all.

The Week 11 slate kicks off with Thursday Night Football on November 18. The full schedule features 15 games since just two teams are on bye, and that is going to mean plenty of markets to bet on. Whether you belong to BetMGM, FanDuel, DraftKings, or another one of the many sites out there, you’re going to want to check out these Week 11 opening lines before you commit to putting your money down.

Week 11 NFL Betting Lines

Game MatchupOpening Line
New England Patriots at Atlanta FalconsFalcons -1.5
New Orleans Saints at Philadelphia EaglesSaints -3.5
Miami Dolphins at New York Jets Dolphins -3
Washington at Carolina PanthersPanthers -1
Indianapolis Colts at Buffalo BillsBills -4.5
Detroit Lions at Cleveland BrownsBrowns -10
San Francisco 49ers at Jacksonville Jaguars49ers -4
Houston Texans at Tennessee TitansTitans -9.5
Green Bay Packers at Minnesota VikingsVikings -3
Baltimore Ravens at Chicago BearsRavens -3.5
Cincinnati Bengals at Las Vegas RaidersRaiders -4.5
Dallas Cowboys at Kansas City ChiefsChiefs -7.5
Pittsburgh Steelers at LA ChargersChargers -2.5
Arizona Cardinals at Seattle SeahawksSeahawks -3.5
New York Giants at Tampa Bay BuccaneersBuccaneers -10

NFL Week 11 matchups and predictions

Thursday, Nov. 18 (8:20 p.m. ET)

New England Patriots at Atlanta Falcons (-1.5)

The Week 11 slate kicks off at Mercedes-Benz Stadium in Atlanta as New England visits the Falcons on a short week. The Patriots opened as 1.5-point favorites and appear to be the stronger team on paper, but the situation does favor the Falcons. Any team who has to condense preparation and travel to play on Thursday is a tough team to bet, though Atlanta doesn’t inspire much confidence either.

Sunday, Nov. 21 (1 p.m. ET)

New Orleans Saints at Philadelphia Eagles (+3.5)

The Saints are on the road for a second straight week, this time in Philadelphia for an early kickoff against the Eagles. In recent years, the Saints have been one of the rare teams to have nearly equal both at home and on the road. Will their game travel the same way with Jameis Winston under center? The Eagles are home underdogs by more than a field goal with an opening line of +3.5 and even with Jalen Hurts & Co. going against a top-flight defende, Philly has a chance to stay in this game.

Miami Dolphins at New York Jets (+3)

The Dolphins and Jets will play twice in a five-week stretch with the first matchup coming at MetLife Stadium in Week 11. The Jets are going to look a bit different in 2021 but this team scored exactly three points in two games against Miami in 2020, so it’s hard to be confident with just the field goal cushion. The Dolphins are a deep team on both sides of the ball and with some improvement from Tua, they’re a legitimate contender in the AFC.

Washington at Carolina Panthers (-1)

Washington traveling to Carolina won’t get nearly as much attention as some of the other games going on in Week 11, but it will feature a couple of the game’s young stars in Christian McCaffrey and Chase Young. The Panthers may have a tougher time reaching the postseason due to its competition level but if the WFT is going to repeat in the NFC East, these are games it needs to win. The home team opened up as a one-point favorite, but we also like the under in a defensive battle.

Indianapolis Colts at Buffalo Bills (-4.5)

A good portion of the NFL-watching universe will have their attention turned to Buffalo when the Colts come to town in Week 11. This is a rematch from Wild Card Weekend last season, which resulted in a close victory for the Bills. Indianapolis shed Philip Rivers but gained Carson Wentz and considering the rest of the offense, there’s reason to think the Colts will be more equipped to keep pace with Josh Allen. The total will be high but it’s worth a look, and so is the home underdog with anything more than four points.

Detroit Lions at Cleveland Browns (-10)

Two games are tied for the largest Week 11 opening line and it shouldn’t shock anyone that one of them involves Detroit. The Lions are on the short side of a huge mismatch when they travel to Cleveland as the Browns play their only home game in a four-week span. Cleveland consistently won home games in 2020 but struggled to cover spreads at a high rate, so this number may give bettors some pause. That said, Jared Goff isn’t known as a cold-weather QB and this is Cleveland in November so the Browns could be ripe for a big win here.

San Francisco 49ers at Jacksonville Jaguars (+4)

The 49ers will travel across the country for an early start against the upstart Jaguars in Week 11. When San Francsico had its success before all the injuries in 2020, it all started with the run game. Jacksonville was one of three teams to allow over 150 rushing yards per game, so that might be the key to this entire game. The road team opened at -4 and even though flying east to play early isn’t supposed to be easy, we still see the Niners winning the game.

Houston Texans at Tennessee Titans (-9.5)

It’s not the largest spread of the week but Houston is still nearly a double-digit underdog in Week 11. There may be no team with more question marks going into the season than Houston, and they may be one of the few teams we don’t back once all season. Tennessee opened at -9.5 at home and with the hook in your direction, taking the Titans seems like the best play.

Green Bay Packers at Minnesota Vikings (-3)

One of the NFL’s great rivalries resumes in Minneapolis in Week 11 when these classic NFC North foes get together. The Vikings opened as three-point favorites at home but if Green Bay is at full strength with Aaron Rodgers and Davante Adams, it’s possible that this line flips around. This is a game where we could see plenty of points scored, as is custom with Vikings home games. Our best bet at this point would be on that total.

Baltimore Ravens at Chicago Bears (-3.5)

Baltimore against Chicago is a bit of a mismatch, so it may appear that Ravens -3.5 on the opening line isn’t too many points. The playing field seems to be leveled a little with the Bears coming off the bye but once you look deeper, you see that Baltimore plays on Thursday the week before and has some extra rest themselves. For that reason, it’s hard not to side with Baltimore, even if they are giving more than a field goal on the road.

Sunday, Nov. 21 (4:05 p.m. ET)

Cincinnati Bengals at Las Vegas Raiders (-4.5)

The Bengals and Raiders meet up in Las Vegas and while the majority of the attention will be elsewhere during this late window, this will be a game to keep one eye on. Both Derek Carr and Joe Burrow are capable of leading offenses up and down the field against these mediocre defenses, so the over may be the very best play. Outside of that, there’s enough points here to back the Bengals and hope this is a one-score game as we get down the stretch.

Sunday, Nov. 21 (4:25 p.m. ET)

Dallas Cowboys at Kansas City Chiefs (-7.5)

In what has the potential to be the most fun game of the week, the Chiefs are hosting the Cowboys at Arrowhead. If the weather cooperates, this is a game that could wind up with scoring in the mid-50s and we’d definitely be looking at the over. Otherwise, it’s hard not to consider Dallas with the opening line at +7.5. Kansas City is a dominant home team but it hasn’t resulted in covering these large spreads in recent seasons.

Pittsburgh Steelers at Los Angeles Chargers (-2.5)

Two AFC playoff hopefuls are facing off in Los Angeles when the Chargers play host to the Steelers. Los Angeles should have one of the league’s most potent offenses while Pittsburgh is known as a stout defense. Oddsmakers appear to think this game’s pretty even, judging by the Chargers opening at -2.5. That said, Mike Tomlin’s teams are known for their ability to cover the number when getting points.

Sunday, Nov. 21 (8:20 p.m. ET)

Arizona Cardinals at Seattle Seahawks (-3.5)

Another NFC West matchup in prime time? Nobody is complaining. This time, it’s the Cardinals visiting the Seahawks with the home team opening as 3.5-point favorites. The Seahawks are notoriously dominant at home and won seven of eight games in Seattle during the 2020 season. Even though these offenses are capable of scoring some points, all eight of Arizona’s road games went under in 2020 and we’d expect that once again depending on the number.

Monday, Nov. 22 (8:15 p.m. ET)

New York Giants at Tampa Bay Buccaneers (-10)

The second game with the week’s largest spread is the last one of the week in Tampa Bay. The Giants are visiting the defending champs as 10-point underdogs but have the benefit of coming off the bye week and having extra time to prepare. Big Blue also kept it close and lost by just two points the last time these teams met in 2020. It’s unlikely the Giants have the firepower to keep up if the Bucs are firing on all cylinders, but this is a lot of points to be giving away.

Brian Sausa Avatar
Written by
Brian Sausa

Brian Sausa is a longtime sports writer with extensive betting experience and knowledge of the industry. A journalism graduate with an extensive sports background, Brian has been employed by multiple professional leagues including MLB, MiLB (Minor League Baseball), and the NHL.

View all posts by Brian Sausa
Privacy Policy