Week 10 NFL Betting Odds: Early Betting Lines, Preview For Every Matchup

Posted By Brian Sausa on July 23, 2021

Following the release of the National Football League’s inagural 18-week schedule, online sportsbooks immediately created opening lines for each game. This means that bettors can gey an early look at betting odds for every matchup over the course of the season.

In this article, we’ve reached Week 10, which begins on November 11 with Thursday Night Football. Four teams are on bye, so 14 games will be played and that means tons of betting opportunities at sportsbooks such as BetMGM, DraftKings, and FanDuel. Let’s get a closer look at each hame by checking out the Week 10 NFL opening lines.

Week 10 NFL Betting Lines

Game MatchupOpening Line
Baltimore Ravens at Miami DolphinsRavens -3
Buffalo Bills at New York JetsBills -7
Tampa Bay Buccaneers at WashingtonBuccaneers -7
Atlanta Falcons at Dallas CowboysCowboys -5.5
New Orleans Saints at Tennessee TitansTitans -2.5
Jacksonville Jaguars at Indianapolis Colts Colts -7.5
Detroit Lions at Pittsburgh SteelersSteelers -7.5
Cleveland Browns at New England PatriotsBrowns -2
Minnesota Vikings at LA ChargersChargers -3
Carolina Panthers at Arizona CardinalsCardinals -6
Philadelphia Eagles at Denver BroncosBroncos -5.5
Seattle Seahawks at Green Bay PackersPackers -3
Kansas City Chiefs at Las Vegas RaidersChiefs -7.5
LA Rams at San Francisco 49ers49ers -3

NFL Week 10 matchups and predictions

Baltimore Ravens at Miami Dolphins (+3)

The week begins with Ravens quarterback Lamar Jackson returning to his hometown as Baltimore visits the Miami Dolphins. This game features two of the four best scoring defenses in the NFL in 2020, so points could be at a premium despite all the talent on the field. Both groups are pretty well-rounded, but Baltimore’s offense is less of a question mark so that probably accounts for the road team being favorites on the opening line. Keep in mind that Miami covered seven of eight home games in 2020.

Buffalo Bills at New York Jets (+7)

The Bills and Jets have met early in the season recently but in 2021, the first matchup isn’t until Week 10. Buffalo is a playoff team and an AFC title contender and while New York’s trajectory points up, this is still a mismatch. The Bills’ offense will score and the Jets may do the same, but it won’t be enough. The Jets are going to look very different than they did in 2020 but it’s worth mentioning that despite going 1-7 at home, New York did cover four times. That said, the Bills were 6-for-8 covering on the road.

Tampa Bay Buccaneers at Washington (+7)

In a playoff rematch, the Bucs are going back to Washington for a matchup with the Football Team. During Wild Card Weekend, the eventual champions disposed of the NFC East winner by a 31-23 score. Tampa Bay is definitely the stronger overall group because its offense is lightyears ahead, but a whole touchdown is plenty of points to give away to an elite defense at home. This game probably won’t have quite as much scoring as that playoff game ended up with, so we’d consider an under depending on the number.

Atlanta Falcons at Dallas Cowboys (-5.5)

The last time these two played, the Falcons added to their growing list of games that involve blowing a massive lead. Atlanta led by 20 in the first quarter and by 15 with under six minutes to go, but still managed to lose to Dallas early in the 2020 season. The rematch may not go any better, as Dak Prescott should be leading a fully healthy Cowboys offense. Atlanta added Kyle Pitts in the draft but still lost Julio Jones and hasn’t upgraded its defense enough to let us pick them. If Dallas is ready to play, this game ends by a touchdown.

New Orleans Saints at Tennessee Titans (-2.5)

The Saints and Titans are two playoff teams that need questions answered after huge changes in the offseason. For New Orleans, Drew Brees retired. In Tennessee, the offensive coordinator and several pieces are gone, while new weapons like Julio Jones were added. The Jameis Winston experience is likely to wind up in points, whether it be for the Saints or for other teams. The Titans’ offense is still a formidable unit and should be able to do its part against a stingy New Orleans defense to push the game close to going over the total.

Jacksonville Jaguars at Indianapolis Colts (-7.5)

In another Week 10 divisional matchup, the Colts will host the Jaguars as 7.5-point favorites on the opening line. By this point in the season, we’ll know what both Jaguars No. 1 pick Trevor Lawrence and newly-acquired Colts QB Carson Wentz look like in their new environments. This is a tough game to bet on until we reach that point, though. Despite a 6-2 home record, Indy only covered three of those games in 2020. The Jaguars lost every road game last year but covered the spread in half of them.

Detroit Lions at Pittsburgh Steelers (-7.5)

It’s Week 10, and we’re once again seeing the Lions as an underdog by more than a touchdown on the opening line. If Pittsburgh plays even close to its talent level, they have no problem in this game. And with the weather starting to get colder and Jared Goff being a warm-weather quarterback historically, we aren’t buying that Detroit can stay very close. This could be one of those games where the Steeelers get right before going on the road for three of the next four games.

Cleveland Browns at New England Patriots (+2)

Over the past two decades, it hasn’t been often that the Patriots are underdogs at home. But in Week 10, Cleveland opened as two-point favorites. From the top down, the Browns have one of the best rosters in the AFC, if not the entire NFL. Even with the Pats’ improvements on offense, Cleveland has more firepower. That said, New England as an underdog in Foxborough is tough to bet against and the Pats will be a trendy moneyline play.

Minnesota Vikings at Los Angeles Chargers (-3)

If you’re looking for DFS players to target in Week 10, don’t look much further. There could be upwards of 50 points when the Chargers host the Vikings in Los Angeles. The home team opened up as three-point favorites, so there isn’t much separating the two sides. We’d lean toward the home team giving away the field goal, but the more obvious play is on the over.

Carolina Panthers at Arizona Cardinals (-6)

We don’t know how the Arizona Cardinals will fare due to their difficult division, but they should play some exciting games. That includes Week 10 against Carolina at home, where Arizona opened as a six-point favorite. The Panthers lost a ton of one-possession games last season but with Christian McCaffrey back and a little bit of luck, some of those can turn into wins or at least covers from a betting perspective. It also feels like a game that would be either 13-10 or 34-31, and I’m not sure which it is just yet.

Philadelphia Eagles at Denver Broncos (-5.5)

This won’t be the most-watched game on the slate, but it could be a sneaky good game when the Broncos and Eagles play at Mile High. Many of the questions we have about these two teams, especially on offense, will have answers by this point. Surprisingly enough, the Denver defense ranked the fifth-worst in 2020 in points allowed at home, not that the Eagles scored much on the road. Perhaps things will be different this time around, but this could be a game where the under is with a look.

Seattle Seahawks at Green Bay Packers (-3)

In a normal setting, a Sunday afternoon matchup between Seattle and Green Bay would be must-see TV for any NFL fan. But how will the Packers look at this point in the season? Entering 2021, Green Bay not only has to worry about future HOF quarterback Aaron Rodgers leaving, but long-term contract talks with star wideout Davante Adams are also stalled. There’s still hope both stars will be in their usual form in green and gold but if not, this line will likely look much different.

Kansas City Chiefs at Las Vegas Raiders (+7.5)

It doesn’t get much better than Sunday Night Football in Las Vegas, and that’s what we get in Week 10 when the defending AFC champs visit the Raiders. These two offenses could blow the lid off the place, but it’s tougher to pick a side. Las Vegas is hard to trust, even at home, but Kansas City hasn’t proven itself a team capable of covering a ton of games due to the inflated spreads we see with their games.

Los Angeles Rams at San Francisco 49ers (-3)

Anytime the NFC West is featured in a primetime setting, we are all being treated to a gift. This division is deep and it always seems to produce competitive games when rivals like the Rams and Niners meet up. San Francisco opened as the customary three-point home favorite, which tells us oddsmakers see this one pretty even. The Rams acquired Matthew Stafford to put them over the edge in games such as these and we think they do just that.

Brian Sausa Avatar
Written by
Brian Sausa

Brian Sausa is a longtime sports writer with extensive betting experience and knowledge of the industry. A journalism graduate with an extensive sports background, Brian has been employed by multiple professional leagues including MLB, MiLB (Minor League Baseball), and the NHL.

View all posts by Brian Sausa
Privacy Policy