Week 10 NFL Betting Picks 2021 | Odds, Previews, And Predictions For Every Game

Written By Brian Sausa on November 10, 2021 - Last Updated on November 14, 2021

Following the release of the National Football League’s inaugural 18-week schedule, online sportsbooks immediately created opening lines for each game. This means that bettors can get an early look at betting odds for every matchup over the course of the season.

In this article, we’ve reached Week 10, which begins on November 11 with Thursday Night Football. Four teams are on bye, so 14 games will be played and that means tons of betting opportunities at sportsbooks such as BetMGM, DraftKings, and FanDuel. Let’s get a closer look at each hame by checking out the Week 10 NFL opening lines.

Week 10 NFL Betting Lines

NFL Week 10 Predictions | Odds, Previews, And Picks For Every Game

Thursday, Nov. 11 (8:20 P.M. ET)

Baltimore Ravens at Miami Dolphins ()

The week begins with Ravens quarterback Lamar Jackson returning to his hometown as Baltimore visits the Miami Dolphins. Baltim0re is 6-2 after an overtime win over Minnesota in which Jackson overcame some early struggles to total almost 400 yards including 120 on the ground by himself.

The Ravens totaled 500 yards of offense against a defense that is better than what the Dolphins are rolling out there so while this number can be had under a full touchdown, take the Ravens. And due to the chance of inclement weather, go with the under.

Picks: Ravens -6.5 (-110 or better), Under 46.5 (-110)

Full Ravens vs. Dolphins Betting Preview

Sunday, Nov. 14 (1 P.M. ET)

Buffalo Bills at New York Jets ()

Watching Buffalo lose to Jacksonville was quite a stunning development, and it’s thoughts and prayers to many survivor players who had the Bills in Week 9. It definitely makes you think twice about giving away double-digit points once again when this team just failed to score a touchdown against the Jaguars.

We’re sure Buffalo won’t have quite as rough of a time with New York as they had in Week 9, because that would be impossible, even if Jacksonville’s defense was among the worst in the league. Mike White is coming off an injury and should struggle with the top-ranked DVOA defense in football, so the Jets aren’t an appetizing option either.

We’re going with a lean toward taking the points with New York having the rest advantage, but the over is the side we like most because of expected positive regression for Buffalo and the Jets managing to score a bit lately with no matter who plays QB.

Picks: Over 47.5 (-110), Jets +13.5 or higher (-110)

Full Bills vs. Jets Betting Preview

Tampa Bay Buccaneers at Washington ()

The Bucs and the Washington Football Team both had byes last week but in Week 10, we get two well-rested teams and an NFC playoff rematch from a season ago. While the Bucs sit comfortably atop the NFC South, the WFT is down in the NFC East basement.

According to Pro Football Focus, the defending champs are No. 2 in passing offense while the WFT is 30th in the league against the pass. Washington is also dead last in passing offense, which doesn’t bode well once you consider the fact that Tampa leads the league in the rushing yards allowed per game, so they won’t be able to run it much either.

Picks: Buccaneers -9.5 (-110), Over 51.5 (-110)

Full Bucs vs. WFT Betting Preview

Atlanta Falcons at Dallas Cowboys ()

The Cowboys laid an egg against Denver at home, but do we really think that happens twice? Dallas came in averaging 40 points per game and was shut down for nearly the entirety of the contest, and that isn’t going to happen again with Atlanta in town. The Falcons, namely Matt Ryan, came up huge in Week 9 to hold on against New Orleans, but this matchup favors Dallas.

Atlanta’s pass defense and run defense have been almost equally unimpressive, and the Cowboys’ offensive line should look much better because of it. But by the same logic we’re using with some of these other games, winning by double digits is a lot to ask for and Atlanta can keep it close enough.

Picks: Over 53.5 (-110 or better), Falcons +10 (-125 or better)

Full Falcons vs. Cowboys Betting Preview

New Orleans Saints at Tennessee Titans ()

Despite losing Derrick Henry, the Titans just keep on trucking thanks to this seemingly newfound strength of the defense, which comes as somewhat of a shock compared to what we saw last season and early on this year, too. It was a turnover-laden 21-point second quarter that the Titans used to bury the Rams in Los Angeles, which has to be one of the most impressive wins of the season.

On the other side, Trevor Siemian had to throw 40+ times against Atlanta because Matt Ryan lit up the Saints’ top-flight defense, and not being able to rely on the run game all day long is a recipe for disaster for New Orleans. We aren’t going to overreact because this is still one of the best passing defenses in football, and the Titans won the game with 194 yards of total offense.

The Titans’ offense is still one-dimensional without Henry. If Seiemien takes care of the ball just a little bit, this doesn’t look like the game Tennessee played against the Rams. Expect Alvin Kamara to take the air out of the ball. This will be a week where the public is on Tennessee, but we’ll go the other way and take the points with New Orleans.

Picks: Saints +3 (-110 or better), Under 45 or less (-110)

Full Saints vs. Titans Betting Preview

Jacksonville Jaguars at Indianapolis Colts ()

In another Week 10 divisional matchup, the Colts will host the Jaguars as huge favorites after playing on Thursday and getting the long rest. Indianapolis’ run game absolutely dominated the Jets to the tune of 260 yards and while this result won’t be quite so gaudy, we expect a similar game plan for Frank Reich.

The Jags are coming off a hugely impressive win over Buffalo, but the Bills’ rushing offense is not nearly the unit that the Colts have. It’s tough to give away double-digits to an underdog who just won outright when +14.5, but Indy is on a roll and has a few extra days to prepare for a team it outmatches all over the field.

Trevor Lawrence and James Robinson are both expected to be back, so that feels like a back-door over waiting to happen. But even a slightly limited Robinson can hamper this offense greatly, so the total is a risk until knowing his full status.

Picks: Colts -10.5 (-110 or better),  Under 47.5 (-110)

Full Jaguars vs. Colts Betting Preview

Detroit Lions at Pittsburgh Steelers ()

Pittsburgh is rounding into form and a big part of it is the elite run defense and a propensity to force field goals in the red zone rather than give up touchdowns. Saving extra four points is exactly how a team with a mediocre offense sticks around long enough to win games. The Steelers’ offensive numbers are ugly, but the Lions are also bottom-feeders when it comes to most pass-defense stats.

That said, all four wins in Pittsburgh’s current streak came by one score and this is too many points to give with a team that hasn’t earned that kind of backing. We also need to keep in mind that Detroit is coming off the bye, and that advantage is enhanced by the Steelers playing last Monday. Look for +10 if it comes, but consider Detroit on the road with the extra rest.

It won’t be fun to watch at all, but one big drive or turnover is all the Lions may need to keep this within the number.

Pick: Detroit Lions +9.5 (-110), Under 43 (-110 or better)

Full Lions vs. Steelers Betting Preview

Cleveland Browns at New England Patriots ()

Nick Chubb is in COVID protocol and Kareem Hunt is already out, so that may be the first step in deciding whether you bet this game or not. But if you’re comfortable with Cleveland’s run game no matter who takes the carries, then go ahead and fade the Patriots, another team dealing with RB injuries.

The Browns’ demolition of the Bengals served as a reminder that the Browns are just fine without Odell Beckham Jr., though I’d like to think many of us knew that already. Nick Chubb averaged an eye-popping 9.8 yards per carry en route to a 137-yard day. And Baker Mayfield has time to throw, the decision-making is more than good enough.

New England is Pro Football Focus’ No. 1 rushing offense, but Cleveland’s defense is also near the top of the league in yards per rush allowed. It also leads the league in yards per rush on offense, while the Pats are average. We’re taking the Browns to win as a short road underdog for a second week in a row.

Picks: Cleveland Browns +1.5 (-110), Under 45.5 (-110)

Full Browns vs. Patriots Betting Preview

Sunday, Nov. 14 (4:05 P.M. ET)

Minneosta Vikings at Los Angeles Chargers )

If this line stays under a field goal, expect the Chargers to be one of the most heavily-bet teams of the week. But if this spread gets public support and still stays under the key number of three, it could be an indication that the most respected bettors in the market are on the road underdog.

The Vikings had success against the Ravens’ average run defense, and Dalvin Cook should see more of it against a bad Chargers unit. Kirk Cousins hasn’t thrown an interception in a month and because of it, the Vikings are one of the best turnover differential teams in football.

Minnesota has lost five games this season, all of them by one score, so we anticipate a close game. Los Angeles is the better team but this is a play on Minnesota at +3 based on some underlying numbers including third-down success

Picks: Vikings +3 (-105), Under 53 or higher (-110)

Full Vikings vs. Chargers Betting Preview

Carolina Panthers at Arizona Cardinals ()

Christian McCaffrey is back, but the Panthers are in bad shape because the Sam Darnold experience is turning out pretty terribly at the moment. Darnold completed less than half of his passes and tossed three picks, even drawing the ire of his own longtime wide receivers like Robby Anderson. Carolina doesn’t want to throw the ball much in theory (unless it’s a dump off to CMC), and it just so happens that Arizona isn’t nearly as good against the run compared to the pass.

With a total at just 45 points, taking the 10 points with the underdogs could be a worthwhile play. Could it end 31-10? It sure could. But Carolina could also put together a couple of drives and toughen up on defense, as we saw Jacksonville do against Buffalo. Not every result makes sense in the NFL, as we’ve come to see. Plus, Kyler Murray and DeAndre Hopkins may not be available or at 100 percent.

Picks: Carolina Panthers +10 (-110), Under 45 (-110)

Full Panthers vs. Cardinals Betting Preview

Sunday, Nov. 14 (4:25 P.M. ET)

Philadelphia Eagles at Denver Broncos ()

After the Broncos dominated the Cowboys, Denver could be popular among the public this week, especially at home. But if you were on the Eagles early enough in Week 9, you actually may have covered (or at least pushed), and this number is around the same.

Philadelphia is one of PFF’s highest-rated rushing teams, and it shredded the Chargers for 176 yards on the ground. Denver is a much better unit and did hold Dallas’ backfield to 78 yards in Week 9, but Ezekiel Elliot only got 10 touches and still gained over five yards per carry.

Picks: Philadelphia Eagles +3 (-115), Under 45 (-110)

Eagles vs. Broncos Betting Preview

Seattle Seahawks at Green Bay Packers ()

The Seahawks and Packers can both expect to have their star quarterbacks under center in Week 10, assuming Aaron Rodgers clears COVID protocol on Saturday. But even if he does, getting 4.5 points with Seattle knowing Wilson is back is an attractive proposition.

Before Russ went down, Seattle was the best yards per play team in football and was notably effective in the run game, but things have gone downhill since the injuries to Wilson and Chris Carson. Despite Carson’s continued absence, Wilson’s return restores some much-needed balance because Green Bay must respect that gorgeous deep ball.

Since losing Week 1, Green Bay with Rodgers under center has been nearly unbeatable, Seattle’s defense is top five in EPA over the past month. And the shoddy run defense for Green Bay opens the door for a Seattle cover with Wilson set to return for an offense that is one of the best in the league on early downs this season.

Picks: Seahawks +4.5 (-110), Under 49 (-110)

Seahawks vs. Packers Betting Preview

Sunday, Nov. 14 (8:20 P.M. ET)

Kansas City Chiefs at Las Vegas Raiders ()

The AFC West is shaping up to be one of the best division races in football, with the Chargers and Raiders on top and Kansas City one game behind. This matchup may go a long way toward deciding which team owns home-field advantage for the opening round, and the Chiefs are favorites despite a miserable go of it from an ATS perspective and all the underlying numbers being in favor of Las Vegas.

Kansas City scraped by the shorthanded Packers but and the Chiefs were still able to keep a zero in the turnover column and Patrick Mahomes was sacked just once. We want to think the positive regression continues in the turnover department for Kansas City and another ho-hum one-score win is in the works, but can the Chiefs stop the Raiders’ passing attack? That remains to be seen and even though underlying numbers are saying Las Vegas, we’re sticking with KC to gut another one out.

Picks: Kansas City Chiefs -2.5 (play up to -115), Under 52.5 (-110)

Chiefs vs. Raiders Betting Preview

Monday, Nov. 15 (8:15 P.M. ET)

Los Angeles Rams at San Francisco 49ers ()

Anytime the NFC West is featured in a primetime setting, we are all being treated to a gift. This division is deep and it always seems to produce competitive games when rivals like the Rams and Niners meet up. Los Angeles is undefeated on the road so far this season and San Francisco is coming off a 14-point loss to Arizona, so is this a bounce-back spot for the Rams?

Arizona ran all over the Niners for 163 yards in Week 9, plus three rushing scores. While the strength of the Rams’ offense has been throwing the ball, we expect to see more of Darrell Henderson as the game plan adjusts following the disappointing game against Tennessee. One bad game from Matthew Stafford doesn’t change much for us, and the Niners offense is going to have a very tough time running the ball, which is vital to its success. The Rams are the top-rated ruin defense according to DVOA.

Picks: Rams -4.5 (-105 or better), Under 49.5 (-110)

Full Rams vs. 49ers Betting Preview

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Brian Sausa

Brian Sausa is a longtime sports content creator with extensive betting experience and knowledge of the industry. A journalism graduate with a ranging sports background, Brian has been employed by multiple professional leagues including MLB, MiLB, and the NHL.

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