Week 6 NFL Betting Odds: Early Betting Lines, Preview For Every Matchup

Posted By Brian Sausa on July 14, 2021

The entire National Football League schedule has been released and for the first time ever, each team will play 17 games over an 18-week season. Once the entire schedule was announced, many online sportsbooks across the United States began posting betting lines for every game throughout the season.

We’re going one slate of games at a time, and we’ve officially reached Week 6, which begins on October 14 with Thursday Night Football and concludes with terrific prime time matchups on Sunday night and Monday. As a result of the new schedule, no teams will receive a bye until now, when four teams will be idle and two less games will be played.

Using opening odds from several sportsbooks including FanDuel, DraftKings, and BetMGM (among others), let’s check out some Week 6 NFL opening lines and preview each matchup.

Week 6 NFL Betting Lines

Game MatchupOpening Line
Tampa Bay Buccaneers at Philadelphia EaglesBuccaneers -7.5
Miami Dolphins at Jacksonville JaguarsDolphins -1.5
Kansas City Chiefs at WashingtonChiefs -6.5
LA Rams at New York GiantsRams -3.5
Houston Texans at Indianapolis ColtsColts -11.5
Cincinnati Bengals at Detroit Lions Bengals -1
Green Bay Packers at Chicago BearsPackers -2.5
LA Chargers at Baltimore RavensRavens -5.5
Minnesota Vikings at Carolina PanthersPK
Arizona Cardinals at Cleveland BrownsBrowns -4.5
Las Vegas Raiders at Denver BroncosBroncos -3.5
Dallas Cowboys at New England Patriots Patriots -1
Seattle Seahawks at Pittsburgh Steelers Steelers -2.5
Buffalo Bills at Tennessee TitansBills -2.5

NFL Week 6 matchups and predictions

Tampa Bay Buccaneers at Philadelphia Eagles (+7.5)

Thursday Night Football will feature the defending champion Bucs visiting Philadelphia as 7.5-point favorites. Tampa Bay was excellent on the road in 2020 with six wins in eight games, but it was only 4-4 against the spread. The Bucs are the superior team but traveling on a short week, it’s tough to lay more than a touchdown. This is a game where Jalen Hurts and the Eagles offense can capitalize on the circumstances and score a little bit.

Miami Dolphins at Jacksonville Jaguars (+1.5)

When these two Florida-based teams meet in Week 6, it will be across the pond in London, which is something of a second home to the Jaguars. The key to this game could be the improvement of Tua Tagovailoa under center compared to the improvement of a Jags defensive unit that struggled mightily in 2020. Miami only opened as 1.5-point favorites so it’s hard not to side with the better overall roster.

Kansas City Chiefs at Washington Football Team (+6.5)

Things don’t get easier for Washington after hosting the Saints in Week 5 because in Week 6, the Chiefs are coming to town. No team gained more yards per game in 2020 than Kansas City, which averaged nearly 30 points per game in the regular season. On the other side, the WFT allowed the fifth-fewest yards per game and was also T-5th in scoring defense. All that said, the road team still opened as favorites of nearly a full touchdown. If Washington’s offense can keep up just a little bit, perhaps there’s some value against a Chiefs team that didn’t cover all that much in 2020.

Los Angeles Rams at New York Giants (+3.5)

The Giants will welcome the Los Angeles Rams to MetLife Stadium in Week 6, and the visitors are 3.5-point favorites. The Rams weren’t the same team on the road in 2020 and New York’s offense should be improved this coming season, so maybe that’s why the line isn’t any larger. But for our money, Los Angeles with Matthew Stafford under center should be able to overcome its defense being a little looser away from home.

Houston Texans at Indianapolis Colts (-11.5)

The largest spread of the week by far is next to this game, where the Colts are giving away 11.5 points to Houston on the opening line. We’re subscribed to the notion that Houston will be a bit of a mess this coming season, and there’s also a chance that the Colts are one of the best teams in the entire NFL if the Wentz-Reich reunion goes off well. We’d usually advise against laying this many points but in this case, Indy may be the only option right now.

Cincinnati Bengals at Detroit Lions (+1)

This isn’t the most appetizing matchup for viewers, but it could be for the Bengals. Cincinnati is the visitor against Detroit, but is still the favorite according to the opening line. It’s hard to envision the game(s) that the Lions will win, and it’s much easier to imagine Joe Burrow carving up that defense in the Ford Field dome. This also feels like a sneaky spot for the over where both offenses find some success, as the Bengals’ defense isn’t exactly elite.

Green Bay Packers at Chicago Bears (+2.5)

The Packers and Bears have one of the great rivalries in the NFL, and that will continue in Week 6 at Soldier Field. It’s amazing to think that Chicago has the more stable quarterback situation at the moment with Andy Dalton, but that is in fact the case. This would be a game to completely lay off until there is some more information about what the future holds for Green Bay, which opened at -2.5 on the road.

Los Angeles Chargers at Baltimore Ravens (-5.5)

Two of the game’s most exciting quarterbacks will be on the same field when Lamar Jackson and the Ravens host Justin Herbert and the Chargers in Week 6. The Ravens will look to re-establish their dominance both running the football and on defense, while Los Angeles hopes to score enough to keep up. For what it’s worth, six of the Chargers’ eight away games went over the total in 2020.

Minnesota Vikings at Carolina Panthers (PK)

Both the Panthers and Vikings are trying to step out of mediocrity, and a win over the other in Week 6 could go a long way. The spread opened at a pick’em, and that may be appropriate because it’s hard to figure out what to make of this game. Carolina’s team has a whole new look with Sam Darnold and quarterback and Christian McCaffrey back in the fold, and Minnesota’s offense should be potent with Dalvin Cook, Justin Jefferson, and Adam Thielen. For that reason, the over may be appealing if you can’t decide on a team to go with just yet.

Arizona Cardinals at Cleveland Browns (-4.5)

Two Heisman Trophy-winning former Oklahoma Sooner quarterbacks will be going head to head when Kyler Murray and the Cardinals visit Baker Mayfield and the Browns. The Cardinals’ offense needs to improve away from home, where it struggles to score. At the same time, it looks to contain a Browns offense that has a bounty of weapons and lights it up at home. It’s also worth noting that all eight of Arizona’s away games went under in 2020, though this one could go the other way.

Las Vegas Raiders at Denver Broncos (-3.5)

The Week 6 schedule is mostly devoid of divisional matchups, but we’ve still got this one from the AFC West. Denver opened as 3.5-point home favorites and will look for better results after dropping both games with Las Vegas in 2020. It appears likely that the Raiders wind up at the bottom of this division, and that would be as a result of losing games like this one. With Denver being the home team, we’d be happy to lay the points if Drew Lock is doing his part early in the season.

Dallas Cowboys at New England Patriots (-1)

New England plays its fourth home game in six weeks to begin the season when Dallas visits Foxborough in Week 6. And after three straight home games, the Cowboys will be on the road, where it hopes to win more than two games this season. With Dak Prescott back in the fold, the Dallas offense should look more like its former self. But with several new faces on offense, the Pats’ offense will also be improved from 2020. New England opened as an ever-so-slight one-point favorite, so oddsmakers view this one as a virtual toss up.

Seattle Seahawks at Pittsburgh Steelers (-2.5)

The Week 6 schedule features several intriguing cross-conference matchups, and Seattle and Pittsburgh is one of them. The Seahawks were an average team on the road in 2020, covering just two of eight games. On the other hand, the Steelers went 7-1 at home and covered five of those games. Pittsburgh opened as 2.5-point favorites for what should be an exciting prime time game.

Buffalo Bills at Tennessee Titans (+2.5)

The week closes with yet another appetizing prime time matchup, this one between the Bills and Titans. Despite being on the road, Buffalo opened as a slight favorite and it’s easy to see why. Tennessee was a bad defensive team in 2020, and won’t be any better in 2021. Against Buffalo’s prolific offense, that’s a problem. On offense, Tennessee added Julio Jones but lost several other weapons. We do expect lots of points here, but Buffalo should score more of them.

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Brian Sausa

Brian Sausa is a longtime sports writer with extensive betting experience and knowledge of the industry. A journalism graduate with an extensive sports background, Brian has been employed by multiple professional leagues including MLB, MiLB (Minor League Baseball), and the NHL.

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