Week 5 NFL Betting Odds: Early Betting Lines, Preview For Every Matchup

Posted By Brian Sausa on July 7, 2021 - Last Updated on July 8, 2021

Nowadays, bettors have the opportunity to wager on any National Football League game they want long before it’s ever set to take place. That’s because online sportsbooks post lines for many games throughout the season once the full regular-season schedule is released.

In this article, we are focused on Week 5. This is the first slate of games to take place entirely in the month of October, as the action begins on October 7 with Thursday Night Football. Using odds from a range of sites including DraftKings, FanDuel, and BetMGM among others, let’s get a look at some NFL Week 5 opening lines.

Week 5 NFL Betting Lines

Game MatchupOpening Line
LA Rams at Seattle Seahawks PK
New York Jets at Atlanta Falcons (London)Falcons -3
Detroit Lions at Minnesota VikingsVikings -8.5
New Orleans Saints at WashingtonSaints -1.5
New England Patriots at Houston TexansPatriots -6
Miami Dolphins at Tampa Bay BuccaneersBuccaneers -7.5
Green Bay Packers at Cincinnati BengalsPackers -3
Denver Broncos at Pittsburgh SteelersSteelers -4.5
Philadelphia Eagles at Carolina PanthersPanthers -3
Tennessee Titans at Jacksonville JaguarsTitans -2.5
Cleveland Browns at LA Chargers Browns -1.5
Chicago Bears at Las Vegas RaidersRaiders -3.5
San Francisco 49ers at Arizona CardinalsPK
New York Giants at Dallas CowboysCowboys -5.5
Buffalo Bills at Kansas City ChiefsChiefs -4.5
Indianapolis Colts at Baltimore RavensRavens -4

NFL Week 5 matchups and predictions

Los Angeles Rams at Seattle Seahawks (PK)

Fans sometimes complain about the quality of the TNF game, but there will be none of that in Week 5. Any NFC West matchup is worthy of prime time, but especially a game featuring the Rams and Seahawks. The last time Los Angeles played in Seattle, it dominated Russell Wilson & Co. in a 30-20 playoff win. This time around, Matt Stafford is under center for a new-look Rams offense. Perhaps appropriately, this one opened at a pick ‘em, and we can’t help but like Los Angeles despite the short week and the travel.

New York Jets at Atlanta Falcons (-3)

The NFL remains an international league that plays several games in London, and the first one of 2021 will include the Falcons hosting the Jets at Tottenham Hotspur Stadium. It’s understandable that an offensively talented Atlanta team would be favored over a Jets group with so many question marks including a rookie likely making his fifth career start at quarterback. That said, the Falcons don’t exactly strike fear into anyone, and the neutral site could be a good reason to take New York and the points.

Detroit Lions at Minnesota Vikings (-8.5)

The biggest favorites of the week are the Minnesota Vikings, which are welcoming the rival Detroit Lions to town as 8.5-point favorites, according to the opening line. The Vikings haven’t been too consistent but one thing Minnesota can do is move down the field and rack up yards, and Detroit ranked dead last in opponent yards per game in 2020. The Lions are a rebuilding team, and there isn’t much to say this one will be very competitive. That said, all roads probably lead to a top-three pick, so it’s something Detroit fans will just have to endure in 2021.

New Orleans Saints at Washington (+1.5)

In a matchup of two elite defenses, the New Orleans Saints will visit the Washington Football Team in Week 5. New Orleans allowed the second-fewest yards per game on defense in 2020, and the WFT ranked fifth. We can’t be sure how Jameis Winston will perform as the Saints’ new starting quarterback, but we know a little bit more of what to expect from veteran gunslinger Ryan Fitzpatrick. Where things stand now, New Orleans at -1.5 on the opening line feels like a bit of a steal, even against the WFT defense at home. We’d also consider the under in this one.

New England Patriots at Houston Texans (-6)

The New England Patriots opened as six-point road favorites against a mysterious Houston Texans team in Week 5. Houston has new brass, a new coach, and may have a new quarterback, but we just don’t know much yet. For the Patriots, the offense has been re-tooled and Cam Newton has been brought back. We expect to see uge improvements from a New England team that was pedestrian last season.

Miami Dolphins at Tampa Bay Buccaneers (-7.5)

The Miami Dolphins are traveling in Week 5, though it won’t be too far. Miami opened as 7.5-point underdogs for its short trip to Tampa to play the defending champions. The Bucs are at home after two straight games on the road and are the second-largest favorites of the week according to the opening lines. Tampa is one of the rare teams that ranked in the top 10 in yards gained and allowed per game in 2020, and they also led the NFL in rushing yards against. Tua will have to throw, so this could be a barometer game for the second-year QB.

Green Bay Packers at Cincinnati Bengals (+3)

Every single Packers game is a huge question mark right now, including this one against the Bengals. Despite being on the road, oddsmakers opened at Green Bay -3 but with the additions to the Bengals’ offense, this could be the time to go contrarian and pick the underdog. Unless you’re taking the Bengals, we’d lay off this one for now, as Aaron Rodgers’ future will alter this line.

Denver Broncos at Pittsburgh Steelers (-4.5)

Around this time in 2020, Pittsburgh was cementing itself as one of the best teams in the NFL. Will it be a similar story in 2021? The defense is elite but Ben Roethlisberger is on his last legs and questions remain about the offense, even if Najee Harris is a universally acclaimed draft pick. The Broncos are quietly assembling one of the underrated rosters in the league, even if we aren’t sure what Drew Lock is going to be.

Philadelphia Eagles at Carolina Panthers (-3)

The Eagles and Panthers are two teams that come with tons of question marks, so looking ahead to this one is a bit difficult. Carolina opened as the customary three-point home favorite, which suggests oddsmakers see this one at about equal. We can’t help but wonder about much of the Eagles’ roster including the offensive line and subsequently, Jalen Hurts’ performance as the starter. We can’t be sure Sam Darnold elevates the Panthers’ offense, but Christian McCaffrey being back and healthy sure does help.

Tennessee Titans at Jacksonville Jaguars (+2.5)

Division foes from the AFC South meet in Week 5 when Tennessee travels to Jacksonville to take on Urban Meyer and Trevor Lawrence. The Jags opened as 2.5-point underdogs, which felt low, but we also must consider all the players the Titans lost this offseason. That said, they did add Julio Jones to the mix so this spread may grow as the game gets closer. One benefit for the home team is that it will be coming off a 10-day rest after playing on Thursday in Week 4.

Cleveland Browns at Los Angeles Chargers (-1.5)

For anyone who enjoys offense, the Cleveland Browns visiting the Los Angeles Chargers could be a sneaky good game on a Week 5 schedule that has a bunch of them. The Chargers opened as a slight favorite, which suggests a one-score game is expected. Los Angeles lost its share of those last year but has a new coach and a budding QB with growing experience. The Browns have one of the best top-to-bottom rosters in football, though, and could pull out a road win.

Chicago Bears at Las Vegas Raiders (-3.5)

When the Chicago Bears visit the Las Vegas Raiders, they will likely do so as slight underdogs. The Raiders opened at -3.5 after going 2-6 at home in 2020, which may be a bit of a surprise. Las Vegas appears to be in no man’s land while Chicago had a strong draft and at least looks to have a plan. The Raiders were 13-3 to the over in 2020 and even though Chicago is known for a tough defense, this game should see some points.

San Francisco 49ers at Arizona Cardinals (PK)

All four NFC West teams are playing divisional games in Week 5, and San Francisco at Arizona opened as a pick ‘em. This game features a battle of strength on strength between the Niners’ defense and the Cardinals’ offense, so it’s likely to be one of the best matchups of the week. For what it’s worth, Murray has a track record of settling in around this point of the season. October was his best month in 2020 with big games against Dallas, New York (Jets), and Seattle. It’s hard to judge anything the 49ers did in 2020 because of all the injuries but assuming they can stay healthy into Week 5, that could be the bet here.

New York Giants at Dallas Cowboys (-5.5)

Rivalry games are all over the place in Week 5 and that includes in Dallas, where the Cowboys will host the Giants. Both teams should be considerably improved in 2020, with New York getting Saquon Barkley back and the Cowboys returning Dak Prescott under center. The NFC East is notorious for beating up on one another but for what it’s worth, Dallas has won four head-to-head matchups in a row at Cowboys Stadium. In 2020, six of the Cowboys’ eight home games went under.

Buffalo Bills at Kansas City Chiefs (-4.5)

The prime-time lineup doesn’t get much better than Week 5 as the Sunday slate closes with a rematch of last year’s AFC title game. Buffalo is once again visiting Arrowhead, where oddsmakers opened with the twice defending conference champion as 4.5-point favorites. This expects to be a game with a high total and plenty of points, so whoever has the ball last may wind up with the best chance at winning. Keep in mind the Chiefs’ struggles covering in 2020 and see if that carries over before placing any bets on this one. Because as of now, we side with Buffalo and the points.

Indianapolis Colts at Baltimore Ravens (-4)

The week will close with a top-tier Monday Night Football matchup in Baltimore, where the Ravens will host the Colts in a game that presents an interesting strength-on-strength matchup. The Ravens ran for the most yards per game in 2020 (192.1), and no other team was even close. On the other side, Indianapolis ranked second in rushing yards against (90.8), excelling even more on the road. Baltimore opened as four-point favorites at home while Indianapolis will be playing its third consecutive game away from home.

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Brian Sausa

Brian Sausa is a longtime sports writer with extensive betting experience and knowledge of the industry. A journalism graduate with an extensive sports background, Brian has been employed by multiple professional leagues including MLB, MiLB (Minor League Baseball), and the NHL.

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