Week 4 NFL Betting Odds: Early Betting Lines, Preview For Every Matchup

Posted By Brian Sausa on July 7, 2021

Thanks to online sportsbooks posting National Football League lines ahead of time, the betting community is being given a new and interesting opportunity. No longer are only the odds from the next week’s slate of games available, as bettors can now use lookahead lines to place wagers on any game throughout the season before the schedule even kicks off.

This time around, we are exiting the opening month of the season and entering Week 4, which begins on Sept. 30 with Thursday Night Football. Using odds from several sportsbooks including DraftKings, FanDuel, and BetMGM, let’s check out NFL Week 4 betting lines and preview each game.

Week 4 NFL Betting Lines

Game MatchupOpening Line
Jacksonville Jaguars at Cincinnati BengalsBengals -2.5
Tennessee Titans at New York JetsTitans -2.5
Kansas City Chiefs at Philadelphia EaglesChiefs -8
Carolina Panthers at Dallas Cowboys Cowboys -5.5
New York Giants at New Orleans SaintsSaints -5.5
Cleveland Browns at Minnesota VikingsBrowns -1.5
Detroit Lions at Chicago Bears Bears -5.5
Houston Texans at Buffalo BillsBills -14
Indianapolis Colts at Miami DolphinsColts -1.5
Washington at Atlanta FalconsFalcons -3
Seattle Seahawks at San Francisco 49ers49ers -3.5
Arizona Cardinals at LA RamsRams -4.5
Pittsburgh Steelers at Green Bay PackersPackers -2.5
Baltimore Ravens at Denver BroncosRavens -3.5
Tampa Bay Buccaneers at New England PatriotsBuccaneers -3.5
Las Vegas Raiders at LA ChargersChargers -4

NFL Week 4 matchups and predictions

Jacksonville Jaguars at Cincinnati Bengals (-2.5)

These may not be playoff teams, but this one will be exciting as it pits the last two No. 1 overall picks against one another. Bengals QB Joe Burrow went with the top selection in 2020 before Jags QB Trevor Lawrence did the same in the most recent draft. Last two No. 1 picks against one another. Cincinnati opened as the customary 2.5-point favorite but if he returns to form in September, this spread could widen as Week 4 approaches.

Tennessee Titans at New York Jets (+2.5)

Tennessee won the AFC South last season and added Julio Jones in free agency to one of the most potent offenses in the league. Granted, the Jets drafted a new quarterback and filled several other holes this offseason, but they are still a middle-of-the-road team at best. The Titans -2.5 line came out before the Jones trade so that number will be gone, but New York will have trouble slowing down Tennessee in this game.

Kansas City Chiefs at Philadelphia Eagles (+8)

The second-largest opening spread of the week is eight points, with visiting Kansas City being the favorite against the Eagles. For all the talk about playing the Chiefs at Arrowhead, this team went 8-0 on the road in 2020, although the team did only cover four of those games. Jalen Hurts will be adjusted to being a starting quarterback from the beginning of a season, and we’ll also know much more about whether Nick Sirianni was the right hire for this struggling offense. This is a game it feels like the Chiefs win, but it’s a lot of points to give away after Kansas City failed to cover a game for two months last year.

Carolina Panthers at Dallas Cowboys (-5.5)

After playing on Monday Night Football, the Cowboys get to stay at home before welcoming the Panthers to town as 5.5-point favorites in Week 4. The Panthers are returning Christian McCaffrey and have a new signal caller in Sam Darnold, so it’s possible this team takes a step from where it did last year. The same should be said for Dallas, which has Dak Prescott coming back and is the favorite to win the NFC East.

New York Giants at New Orleans Saints (-5.5)

When Big Blue visits the Superdome in Week 4 they will do so as 5.5-point favorites. This is one of those games that feels incredibly difficult to predict. The Giants were one of the league’s worst offenses but they’ve added weapons and got Saquon Barkley back. The Saints are a playoff team that is getting a new starting QB in Jameis Winston. We may get a decent amount of points and with the spread under a touchdown, the Saints at home are hard to lay off.

Cleveland Browns at Minnesota Vikings (+1.5)

The Browns are traveling to Minnesota as 1.5-point favorites, which is tied for the lowest opening spread of the week. These two teams went in opposite directions in 2020, with the Browns getting back to the playoffs and the Vikings faltering too many times to count. Minnesota went 2-6 against the spread at home and hasn’t improved all that much, so we’d recommend Cleveland as of now.

Detroit Lions at Chicago Bears (-5.5)

It feels like every week is a tough draw for Detroit, which will visit Soldier Field as 5.5-point underdogs against the Bears. We don’t know exactly what the Andy Dalton-led Bears will look like, but we have a good idea of what the Lions will be, and it’s not good. Jared Goff isn’t a good cold-weather quarterback, and this has all the makings of a big Bears win.

Houston Texans at Buffalo Bills (-14)

It’s becoming common that the biggest favorite of any given week is the team playing against the Houston Texans. In Week 4, that’s the Bills with a -14 opening line. Buffalo is superior in every facet of the game and assuming Watson won’t be playing, the Bills are capable of winning by three touchdowns. That said, this is a huge chunk of points to lay. Some kind of alternate line backing Buffalo or the over could be interesting options.

Indianapolis Colts at Miami Dolphins (+1.5)

The other game with a miniscule 1.5-point opening spread is this one, with the visiting Colts favored in Miami. The Colts led by Carson Wentz will be one of the trending topics of the season and if this reunion with Frank Reich works out, Indy could win the division. But be wary of betting against Miami at home after they went 7-1 against the spread in 2020. This game is likely to be a one-score affair late into the fourth quarter.

Washington Football Team at Atlanta Falcons (-3)

The Atlanta Falcons opened as three-point favorites against the Washington Football Team at home in Week 4. This number is strange to us to begin with, but it obviously looks worse with Julio Jones out of the picture. Atlanta still has weapons on offense, but Washington’s defense is its strength. Ryan Fitzpatrick should be able to do enough damage to give the WFT a chance to win this one straight up.

Seattle Seahawks at San Francisco 49ers (-3.5)

The last two NFC West winners will square off in Week 4 when the Seahawks travel to San Francisco as 3.5-point underdogs. Seattle won both games last year and these two always play close contests. That said, the Niners will be a different-looking team with new coordinators and Jimmy Garropolo back under center after he was hurt for both matchups in 2020.

Arizona Cardinals at Los Angeles Rams (-4.5)

The NFC West may very well be the deepest in the NFL, and that includes Arizona and the Rams, though Los Angeles is the stronger overall group. The Rams opened at -4.5 and that seems fair since they’re at home with one of the best defenses in the league and a new Pro Bowl QB in Matt Stafford. It’s worth noting that all eight of the Rams’ home games went under in 2020, as did all eight of Arizona’s road games.

Pittsburgh Steelers at Green Bay Packers (-2.5)

Two playoff teams from last year will meet at Lambeau in Week 4, with the visiting Steelers opening as 2.5-point underdogs. With the status of Aaron Rodgers up in the air, it’s hard to bet on any Packers games. But if we were to, we’d take the value with the underdogs where things currently stand. There’s a chance that this spread can slim down depending on future events, so any early wagers are a bit blind when it comes to all the information. The Packers normally dominate at home but the Steelers do bring to town an elite defense.

Baltimore Ravens at Denver Broncos (-3.5)

When the Denver Broncos host the Baltimore Ravens in Week 4, they will do so as underdogs after Baltimore opened up with a -3.5 spread. The Ravens are playing away from home in three of the first four weeks, so the Broncos could benefit if Baltimore is a big road-weary in this spot. The problem is, Denver went 2-6 at home last season and we still don’t know whether it will be Drew Lock or Teddy Bridgewater at QB, which makes betting on this game difficult.

Tampa Bay Buccaneers at New England Patriots (-3.5)

Regardless of what games were on the schedule, this was always going to be the most anticipated game of the week. Tom Brady returns (as a champion) to New England for the first time as a member of the Bucs, and we are all treated to the spectacle in prime time. Oddsmakers made the Bucs -3.5 to open this one, and we’re inclined to side with the road team. Tampa Bay is deeper on both sides and if we know one thing about Brady, it’s that he’s as competitive as they come. He’ll feel the love from the crowd but won’t want to lose.

Las Vegas Raiders at Los Angeles Chargers (-4)

In a week with several divisional matchups, an AFC West clash closes out the schedule as the Chargers host the Raiders. Each of these teams beat the other on the road in 2020, but Los Angeles opened as a four-point favorite with reigning Offensive Rookie of the Year Justin Herbert at quarterback. The Raiders covered six of eight games on the road last season, but the Chargers should be the stronger team on both sides of the ball in this Monday Night Football matchup.

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Brian Sausa

Brian Sausa is a longtime sports writer with extensive betting experience and knowledge of the industry. A journalism graduate with an extensive sports background, Brian has been employed by multiple professional leagues including MLB, MiLB (Minor League Baseball), and the NHL.

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