Week 2 NFL Betting Odds: Early Betting Lines, Preview For Every Matchup

Posted By Brian Sausa on June 11, 2021

There’s still some time until the 2021 National Football League season kicks off, but that doesn’t mean that sports bettors aren’t already pouring through the schedule looking for an edge. After all, there’s never a bad time to start handicapping for the NFL season.

The betting community is spoiled by the fact that online sportsbooks have NFL lines posted for every single game of the season in the wake of the new 18-game schedule release. Now, we get to analyze moneylines, spreads, and totals for any game we wish, regardless of when it’s going to be played.

Here, we’re focusing on the second week of the season, which begins on Sept. 16. With help from several sportsbooks including DraftKings, FanDuel, and BetMGM (among others), let’s get a closer look at NFL Week 2 betting odds.

Week 2 NFL Betting Lines

Game MatchupOpening Line
New York Giants at WashingtonWashington -3
New England Patriots at New York JetsPatriots -3
Denver Broncos at Jacksonville JaguarsBroncos -1.5
Buffalo Bills at Miami DolphinsBills -3.5
San Francisco 49ers at Philadelphia Eagles49ers -4
LA Rams at Indianapolis ColtsColts -1.5
Las Vegas Raiders at Pittsburgh Steelers Steelers -5.5
Cincinnati Bengals at Chicago BearsBears -3.5
Houston Texans at Cleveland BrownsBrowns -13.5
New Orleans Saints at Carolina PanthersSaints -2.5
Minnesota Vikings at Arizona CardinalsCardinals -3.5
Atlanta Falcons at Tampa Bay BuccaneersBuccaneers -9.5
Tennessee Titans at Seattle SeahawksSeahawks -3.5
Dallas Cowboys at LA ChargersChargers -1.5
Kansas City Chiefs at Baltimore RavensPK
Detroit Lions at Green Bay PackersPackers -7.5

NFL Week 2 matchups and predictions

New York Giants vs. Washington Football Team ()

The second week of the NFL season begins with an NFC East clash between the Giants and the Washington Football Team, with the home squad opening as a field-goal favorite. Despite the fact that Washington won the division, New York beat them twice and will have Saquon Barkley in the backfield, while Washington rolls with Ryan Fitzpatrick at QB. The total will be pretty low but keep in mind that WFT played just two home games to the over last season, while New York went over just once on the road.

Cincinnati Bengals at Chicago Bears ()

With new QB Andy Dalton under center, the Chicago Bears host the Cincinnati Bengals in their home opener in Week 2. Chicago opened up as 3.5-point favorites against a Bengals team that went 1-6-1 against the spread in 2020, but will have quarterback Joe Burrow back in addition to his former LSU teammate Ja’Marr Chase.

Houston Texans at Cleveland Browns ()

The Browns’ home opener is against the Houston Texans, a team that most don’t expect much from in 2021. There’s an extra layer of uncertainty around this team considering the Deshaun Watson situation, so what happens next is anyone’s guess. It should come as no surprise that Cleveland is the biggest favorite of Week 2 according to the opening lines, and it’s just a matter of whether they cover the number. The Browns were 6-2 at home in 2020 but only went 4-4 against the spread.

Los Angeles Rams at Indianapolis Colts ()

The Rams and Colts are playoff hopefuls with new faces under center, and they get to battle it out in Indianapolis during Week 2. The Colts, now with Frank Reich and QB Carson Wentz reunited, are seen as about even with Los Angeles and Mattew Stafford. These teams will be postseason contenders and this will serve as a barometer game for both sides. The total will be interesting to watch since the Colts went 13-3 to the over last year while the Rams were just 4-12.

Buffalo Bills at Miami Dolphins ()

This is the first AFC East game for Buffalo after running away with the division in 2020 and despite being on the road, the Bills opened at -3.5. Miami gets two division games to open the season after playing New England in Week 1, so we’ll know early on whether Tua Tagovailoa and the Dolphins offense took some steps forward. Miami did cover seven of eight games at home last season.

New England Patriots at New York Jets ()

The first home game for the new-look New York Jets will be against the rival Patriots, who are field goal favorites on the road. We know what the Jets were last season but with Robert Saleh as coach, Zach Wilson at quarterback, and some new weapons on offense, this team could be a live underdog. The Pats are three-point favorites on the road after opening up the season at home against Miami.

San Francisco 49ers at Philadelphia Eagles ()

The 49ers begin the season in Detroit and go even further east to Philadelphia in Week 2. Either you think this is a long time to be away from home, or they’ll be fully acclimated to the east coast by this time. Either way, oddsmakers opened with the Niners as four-point road favorites against Jalen Hurts and the Eagles, a team making its home debut with new coach Nick Sirianni.

Las Vegas Raiders at Pittsburgh Steelers ()

Another west team travels east for a 1pm game as Las Vegas visits Heinz Field. The Raiders could be a welcome site for the Steelers after facing Buffalo in Week 1, and Pittsburgh has opened as 5.5-point favorites. This Steelers started last season 11-0 before struggling down the stretch, and the Raiders went 6-2 on the road a season ago.

New Orleans Saints at Carolina Panthers ()

The new-look Panthers get their first taste of the NFC South against the Saints, who have some new faces of their own. Sam Darnold will be under center for Carolina and Christian McCaffrey will be back, while Jameis Winston takes the reins following Drew Brees’ retirement. New Orleans opened at -2.5 on the road after going 6-2 away from the dome in 2020.

Denver Broncos at Jacksonville Jaguars ()

Urban Meyer and Trevor Lawrence will finally debut at home in Week 2 when the Jags host the Broncos. Denver opened as a slight favorite in this one, but this could end up being a good spot for the home underdog. The Broncos start the season on the east coast against the Giants and will remain there for a second straight week, but Vic Fangio is sure to have a plan for the rookie QB.

Minnesota Vikings at Arizona Cardinals ()

The Vikings are on the road for the first two games, facing Arizona in Week 2. Minnesota was disappointing in 2020 and there are still question marks about this team despite bright spots like Justin Jefferson. The Cardinals opened at -3.5 and are coming off contending for a postseason spot until the very end of the season. In his third season, we look for Kyler Murray to make a jump as well.

Atlanta Falcons at Tampa Bay Buccaneers ()

The Super Bowl champion Bucs get to open the season at home on Thursday, then rest for 10 days before welcoming the Falcons to town in Week 2. This is a huge advantage for Tampa Bay, which did not lose a game after Week 12 last season. It’s not a shocker that the Bucs are huge favorites and now that Julio Jones is gone from Atlanta, we certainly have to wonder if the Falcons can keep up offensively.

Dallas Cowboys at Los Angeles Chargers ()

Dallas plays in Tampa Bay to open the season and gets an early respite with 10 days before their next game in Week 2. The LA Chargers and offensive rookie of the year Justin Herbert will make their 2021 home debut against a defense that gave up a ton of explosive plays a season ago. The Chargers opened as a slight favorite and since both of these groups are expected to be postseason contenders, an early-season win would do wonders.

Tennessee Titans at Seattle Seahawks ()

The Seahawks will play their first game at home and opened as 3.5-point favorites in Week 2 against the defending AFC South champion Tennessee Titans. Seattle better hope its defense is improved, because the Titans’ offense is a prolific one which just added Julio Jones as well. For what it’s worth, Seattle was 7-1 at home and 6-2 against the spread in 2020, while Tennessee covered three of eight away games. We should also expect some points in this one.

Kansas City Chiefs at Baltimore Ravens ()

In what should be one of the highlights of the early season, the Ravens host the AFC champion Chiefs in prime time during Week 2. This game opened as a pick ‘em, which seems appropriate but it should be noted that Kansas City was 8-0 on the road in 2020. This Ravens defense will be his first big test for the Chiefs’ high-octane offense, though we still expect some fireworks from both sides. Baltimore opens the season on Monday Night Football, so we’ll get plenty of looks at Lamar Jackson in September.

Detroit Lions at Green Bay Packers ()

The Packers’ first home game of the season comes on Monday Night Football and is the first time they’ll be at Lambeau since losing the NFC title game. There’s no doubt Green Bay is head and shoulders above a rebuilding Detroit team, which is why the Packers opened at -7.5. But this is a bet you may need to wait on without knowing Aaron Rodgers’ status with the team.

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Brian Sausa

Brian Sausa is a longtime sports writer with extensive betting experience and knowledge of the industry. A journalism graduate with an extensive sports background, Brian has been employed by multiple professional leagues including MLB, MiLB (Minor League Baseball), and the NHL.

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