The San Francisco 49ers (6-4) and New Orleans Saints (4-7) will face each other in a Week 12 matchup. The 49ers, listed at on the spread, play host to the Saints, to win, on November 27, 2022 at 4:25 PM ET on FOX. The total for the matchup is set at points.
The betting facts in this article reference odds valid as of November 27, 2022 at 4:48 PM ET. See the table below for the latest odds on this game and click here to get the best DraftKings Sportsbook deposit bonus!
49ers Vs Saints Odds
Computer Pick
| ATS pick | Over/Under pick |
|---|---|
| 49ers (-8.5) | Over (43.5) |
Predictions are calculated by a data-driven algorithm (raw power score) that ranks head-to-head matchup results within a closed network of games. Prediction confidence is determined by the delta between each team’s raw power score.
Team Stat Rankings
| 49ers | Saints | |
|---|---|---|
| Off. Points per Game (Rank) | 23.6 (17) | 22.6 (11) |
| Def. Points per Game (Rank) | 17.3 (2) | 24.3 (27) |
| Off. Yards per Play (Rank) | 6.0 (4) | 5.8 (6) |
| Def. Yards per Play (Rank) | 4.7 (2) | 5.2 (9) |
| Turnovers Allowed (Rank) | 13 (14) | 19 (30) |
| Turnovers Forced (Rank) | 12 (20) | 7 (31) |
49ers Betting Insights
- The 49ers have beaten the spread five times in 10 games.
- San Francisco is unbeaten ATS (2-0) as an 8.5-point favorite or greater this year.
- The 49ers have seen four of its 10 games go over the point total.
- The 49ers and their opponent have broken the 43.5-point mark four times this season.
- The over/under for this game is 43.5 points, 0.5 more than the average point total for San Francisco games this season (playoffs included).
Saints Betting Insights
- The Saints’ record against the spread is 4-7-0.
- Out of 11 Saints games so far this year, six have hit the over.
- There have been six New Orleans games this year with more than 43.5 points scored.
- The over/under for this game is 0.3 points higher than the average scoring total for Saints games (43.2).
49ers Players to Watch
- Jimmy Garoppolo has thrown for 2,159 yards (239.9 ypg) to lead San Francisco, completing 67% of his passes and collecting 15 touchdown passes compared to four interceptions this season.
- The team’s top rusher, Christian McCaffrey, has carried the ball 132 times for 602 yards (60.2 per game) and four touchdowns. He’s proven to be a dual threat, hauling in 462 receiving yards on 54 catches with two touchdowns through the air.
- This season, Deebo Samuel has carried the ball 31 times for 202 yards (22.4 per game) and two touchdowns, while also racking up 468 yards through the air with two touchdowns.
- Brandon Aiyuk’s team-leading 587 yards as a receiver have come on 46 receptions (out of 65 targets) with six touchdowns.
- Nick Bosa paces the team with 10.0 sacks, and also has 11.0 TFL and 29 tackles.
- Fred Warner, San Francisco’s tackle leader, has 75 tackles, 5.0 TFL, and 3.0 sacks this year.
- Talanoa Hufanga has picked off a team-high four passes. He also has 56 tackles, 3.0 TFL, 1.0 sack, and seven passes defended to his name.
Saints Players to Watch
- Andy Dalton leads New Orleans with 1,819 yards on 162-of-242 passing with 14 touchdowns compared to seven interceptions this season.
- The team’s top rusher, Alvin Kamara, has carried the ball 124 times for 511 yards (56.8 per game), with one touchdown this year. He’s proven to be a dual threat, hauling in 385 receiving yards (42.8 per game) on 43 catches with two receiving touchdowns.
- Taysom Hill has run for 396 yards across 52 attempts, scoring five touchdowns.
- Chris Olave has racked up 760 receiving yards on 51 catches to pace his team so far this season while scoring three touchdowns as a receiver.
- Juwan Johnson’s 47 targets have resulted in 31 catches for 349 yards and five touchdowns.
- Demario Davis, the team’s tackle and sacks leader, has amassed 7.0 sacks, 8.0 TFL and 69 tackles.
- Tyrann Mathieu has picked off a team-leading two passes. He also has 56 tackles, 1.0 TFL, and four passes defended to his name.
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