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Two of the NFL’s most injury-ravaged teams in the Philadelphia Eagles (0-2-1) and San Francisco 49ers (2-1) meet on Sunday Night Football in Week 4. The Eagles are one of the league’s most disappointing teams through three weeks, and they’re coming off a shocking tie against the Cincinnati Bengals on their home field. Meanwhile, the 49ers just won back-to-back games at MetLife Stadium against the New York Jets and New York Giants in convincing fashion. Our Sunday Night Football betting breakdown shops the betting odds and lines at DraftKings Sportsbook and FanDuel Sportsbook. We’ll then offer up the best picks and bets for the moneyline, spread and over/under in the Week 4 Sunday Night Football matchup between the Eagles and 49ers.

The 49ers opened as 3.5-point betting favorites last week but that line has ballooned to 7 points. The vastly different Week 3 results for the two teams and an abundance of injuries on either side have led to an increased gap. The projected point total is set at 46 as one of the lowest totals of Week 4. Actionable advice on our three bet types will be provided as either a “pick” or a “lean”. Picks can be made with a high degree of confidence at the current odds. Leans are advised in anticipation of the lines moving in either direction. This can happen in correlation with injury updates or public betting action.

Before finalizing your Week 3 bets for SNF, be sure to check out our Sunday Night Football Betting Preview at TheLines. There, we analyze the on-field matchup and look at each team’s betting results through their first three games of the 2020 NFL season.

Eagles at 49ers odds

Eagles at 49ers picks: Moneyline

Both teams were the betting favorites for the outright win in each of their first three games of the season. San Francisco enters at 2-1 with an average margin of victory of 13.7 points. Philadelphia is a lowly 0-2-1 and losing by an average of 9.3 points per game. The Niners are tied for second in the NFC West; the Eagles are third in the wide-open NFC East.

The 49ers are one of five home teams favored by at least 7 points this week. As such, they’re priced as one of the biggest moneyline favorites of Week 4 at both DraftKings and FanDuel. They won each of their last two games as big road favorites against the Jets and Giants after suffering a home upset against the division rival Arizona Cardinals in Week 1. The Eagles were 4.5-point home favorites last week. Before the tie, their previous two losses came by 10 and 18 points.

San Francisco is well worth the chalk at home in Week 4. Take the Niners to win outright

The pick: 49ers (-320 or better)

Eagles at 49ers picks: Against the spread

The Niners are favored by at least 7 points for the fourth time this season; the Eagles are underdogs for the first time in four games. San Francisco has a 2-1 ATS record to match its outright record. Philly is 0-3 ATS.

Both offenses are ravaged by injuries. 49ers QB Jimmy Garoppolo (ankle) and RB Raheem Mostert (knee) both missed practice Wednesday and are unlikely to play for the second week in a row. WR Deebo Samuel (foot) will return to boost the receiving corps. Defensively, DL Dee Ford (back) and LB Dre Greenlaw (quadriceps) front the injury report.

Eagles TE Dallas Goedert (ankle) and WR Jalen Reagor (thumb) were placed on injured reserve Wednesday. WR DeSean Jackson (hamstring) missed practice but should be available Sunday. The already-depleted receiving corps hasn’t done him any favors, but QB Carson Wentz has thrown six interceptions against three touchdowns. He has a career-worst 63.9 quarterback rating through three games.

The Niners received some positive news Wednesday; TE George Kittle (knee) returned to full practice and RB Jerick McKinnon (ribs) also practiced in full. Rookie WR Brandon Aiyuk is coming off a breakout Week 3 performance with five catches for 70 yards and another 31 yards and a score on the ground. QB Nick Mullens will likely start for the second week in a row in place of Jimmy G. He’s coming off a 343-yard, 1-touchdown performance against the Giants. The return of Kittle, the emergence of Aiyuk, and the expected availability of McKinnon will give him the assets he needs to outscore the woeful Eagles offense by a wide margin.

The pick: 49ers -7 (-110 or better)

Eagles at 49ers picks: Over/Under (total)

The projected point total of 46 is one of the lowest on the Week 4 slate. It’s also among the lowest of any primetime game this season. Both teams are 2-1 against the O/U thus far. Philadelphia has played an average of 4.0 PPG above the lines with the opposition doing the heavy lifting. San Francisco is averaging 0.3 fewer PPG than projected.

The offensive injuries garner the attention of bettors and fantasy managers alike, but both teams are nearly equally affected on the defensive side. Niners DL Dee Ford (back), LB Dre Greenlaw (quadriceps), and CB Emmanuel Moseley (concussion) all missed practice Wednesday. The Eagles were missing DT Fletcher Cox (abdominal), CB Trevor Williams (ribs), and S Rudy Ford (groin) from the first practice of the week.

Mullens shouldn’t be considered that far of a drop from Garoppolo after helping the Niners put up 36 points last week, albeit against a lowly Giants team. It was the second straight week with San Francisco topping 30 points after scoring just 20 in the season opener.

The key to this pick will be the Eagles’ ability to score points. They’ve been held below 20 in two of three games. The lean is to the Over, but back off and pass if Jackson doesn’t suit up or the 49ers have a fully healthy defense.

The lean: Over 46 (-110 or better)

Best SNF prop bet

First to 30 points: 49ers (+148 or better)

The return of Kittle will be a big boost to a 49ers team coming off back-to-back road wins with a total of 67 points scored. The Eagles were victimized by Los Angeles Rams TE Tyler Higbee in a 37-19 loss in Week 2, and Kittle is by far his superior. He’ll represent the biggest mismatch of the day for either side.

This prop also falls in line with our other picks of 49ers -7 and Over 46. Whether it’s Mullens or Garoppolo under center for the home side, they’ll score enough to win this game. And there’s little fear of the Eagles winning this race on the scoreboard.