Astros Vs Guardians: MLB Betting Lines, Stats And Predictions – May 25, 2022

Written By PlayPicks Staff on May 25, 2022

The Cleveland Guardians (18-21) are looking for continued power from a batter on a hot streak against the Houston Astros (28-16) on Wednesday at 8:10 PM ET, at Minute Maid Park. Jose Ramirez is riding a two-game homer streak. Cristian Javier pitches for Houston (-184 to win) while Cleveland (+156) will answer with Cal Quantrill.

The insights in what follows reference odds valid as of May 25, 2022 at 7:12 PM ET. Check out the table below for the latest odds for this contest and get up to $1,000 Risk Free Bet at FanDuel today!

Astros vs Guardians Betting Lines

Astros Betting Insights

  • The Astros have won 24, or 70.6%, of the 34 games they’ve played as favorites this season.
  • This season, Houston has won nine of its 10 games, or 90%, when favored by at least -184 on the moneyline.
  • The Astros have a 64.8% chance to win this game based on the implied probability of the moneyline.
  • Houston and its opponents have gone over the total this season in 12 of their 44 opportunities.
  • The Astros are 23-21-0 against the spread in their 44 chances this season.

Astros Last 10 Games Trend

Stat Avg/Total
Record 6-4
Runs Per Game 4.5
HR 15
ERA 2.35
K/9 8.28

Guardians Betting Insights

  • The Guardians have been victorious in 11, or 40.7%, of the 27 contests they have been chosen as underdogs in this season.
  • This season, Cleveland has come away with a win three times in eight chances when named as an underdog of at least +156 or longer on the moneyline.
  • Oddsmakers have implied with the moneyline set for this matchup that the Guardians have a 39.1% chance of pulling out a win.
  • Cleveland and their opponents have hit the over in 21 of their 39 games with a total set by oddsmakers this season.
  • In 39 games with a line this season, the Guardians have a mark of 19-20-0 against the spread.

Guardians Last 10 Games Trend

Stat Avg/Total
Record 3-7
Runs Per Game 3.6
HR 10
ERA 3.78
K/9 7.36

Guardians Probable Pitcher – Cal Quantrill

  • Quantrill (1-2) takes the mound first for the Guardians in his eighth start of the season. He’s put together a 3.48 ERA in 41 1/3 innings pitched, with 25 strikeouts.
  • The right-hander’s last time out was on Thursday against the Cincinnati Reds, when he went seven innings, surrendering one earned run while giving up five hits.
  • Quantrill will try to build upon a six-game streak of pitching five or more innings (he’s averaging 5.3 frames per outing).
  • The Guardians are 2-3 in Quantrill’s five starts this season that they were the underdog on the moneyline.
  • Quantrill’s team has a 2-5 record in his starts this season.
  • Quantrill has started seven games with a total set by oddsmakers this season. The teams have combined to go over the run total in three of them.
  • Pitchers reflected above are based on projections as of May 25, 2022 at 7:12 PM ET and may not be the pitchers at game time.

Guardians Relief Pitchers

Name Relief App. IP K/9 H/9 HR/9 ERA
Emmanuel Clase 18 16.1 8.8 7.2 0.6 3.31
Bryan Shaw 17 12.2 5.0 12.0 3.0 5.68
Trevor Stephan 16 16.2 8.6 9.0 0.0 2.70
Nick Sandlin 14 14.0 5.8 7.4 1.6 3.21
Sam Hentges 14 15.1 10.6 4.5 0.0 1.17

Astros Probable Pitcher – Cristian Javier

  • Javier and his team have a record of 1-3-0 against the spread when he starts.
  • The right-hander’s last start was on Saturday, when he tossed six innings while giving up one earned run on three hits in a matchup with the Texas Rangers.
  • Javier’s team has won 50% of his starts when they are favored on the moneyline (2-2).
  • In games Javier has started, his team is 2-2.
  • Games started by Javier have a 1-3-0 record at hitting the over this season.
  • Pitchers reflected above are based on projections as of May 25, 2022 at 7:12 PM ET and may not be the pitchers at game time.

Astros Relief Pitchers

Name Relief App. IP Ks ERA Holds Saves
Héctor Neris 21 20.0 20 2.25 7 0
Rafael Montero 19 17.2 20 0.51 5 3
Phil Maton 19 20.0 12 3.60 6 0
Ryne Stanek 17 15.2 13 1.15 2 1
Blake Taylor 16 14.0 7 3.86 3 0

Astros Hitting Trends

  • The Astros have won all of the 14 games this season when they hit at least a pair of home runs.
  • The Astros are 8-1 in games this season when they have had five or more extra-base hits.
  • The team has totaled at least eight hits in 21 games this season, and is 16-5 in those contests.
  • The Astros are 16-1 in games this season that they put up at least five runs.
  • The Astros have drawn at least five walks in 14 games this season, and are 13-1 in those contests.

Guardians Hitting Trends

  • They are 5-2 this season when they hit two or more home runs in a game.
  • They have won each of their six games this season in which they’ve connected for five or more extra-base hits.
  • They have a record of 16-3 this season when collecting eight or more base hits in a game.
  • In 15 games this season with five or more runs scored, they’ved posted a record of 14-1.
  • They have a 4-3 record this season when drawing five or more walks in a game.

Astros vs. Guardians Prediction

Moneyline Pick: Guardians (+156)

Over/Under Pick: Over (8)

Predictions are calculated by a data-driven algorithm derived from offensive performance metrics and probable starting pitchers.

Powered By Data Skrive using data from

PlayPicks Staff Avatar
Written by
PlayPicks Staff

PlayPicks staff has years of sports betting and DFS knowledge and we share all of that with you for free daily.

View all posts by PlayPicks Staff
Privacy Policy