Week 18 NFL DFS Picks | Best Bets For DraftKings And FanDuel Lineups

Written By Nate Weitzer on January 7, 2022 - Last Updated on January 9, 2022

We’ve made it to the end of the NFL’s first 17-game season and Week 18 brings a huge slate of Daily Fantasy Sports (DFS) contests offered on DraftKings and FanDuel with big prize pools and exciting formats such as Best Ball and Showdown mode.

Whether you’re located in a state that won’t allow you to wager on NFL odds or just prefer DFS to traditional sports betting, there are many contests to choose from each and every week of the season. Here, we’ll provide you with lineup advice for a variety of contests including cash games (i.e. 50/50, H2H, and Double-Up) and GPP (Guaranteed Prize Pool) tournaments.


Week 18 NFL DFS Lineup Picks | Predictions For DraftKings & FanDuel

Whether you play at DraftKings or FanDuel, we want to make the process of choosing your lineup as simple as possible. Below, we have suggestions for several different DFS contest types along with prices for each player from both sites.


Best Play: Josh Allen (DK: $8,100, FD: $8,800)

The Bills have been utilizing Allen more and more as a runner, as he’s averaging 69.5 rushing YPG with three rushing TDs over his last four starts. He should be able to burn the Jets through the air or on the ground this week considering his opponent ranks 31st in DVOA pass defense and 26th in DVOA rush defense.

Allen completed 21 of 28 passes for 366 yards and two TDs while averaging a season-high 13.1 yards per attempt at the Jets in Week 10. The Jets are yielding 8.4 adjusted yards per attempt and a 107 passer rating with a 13:3 TD:INT ratio allowed on the road this season. They also allow 4.6 YPC on the road and Allen is averaging 5.9 YPC with four rushing TDs over eight home games.

Value Play: Taysom Hill (DK: $6,200, FD: $7,700)

The Saints are in a must-win situation against a Falcons team that isn’t particularly good against the run or the pass. Atlanta has faced the most rushing attempts (86) and allowed the third-most rushing yards (413) to QBs this season.

Last year, Hill burned this defense for 132 rushing yards on 24 totes and he scored two TDs as a gadget player against Atlanta in a 2019 meeting. He’s logged at least 11 rushing attempts in all four of his starts and that gives him a solid floor with great upside against the Falcons’ 30th-rated rush defense.

GPP Play: Kyler Murray (DK: $7,400, FD: $8,400)

Murray and Russell Wilson ($6,300; $7,500) could get into a shootout into what might be Wilson’s final game in a Seahawks uniform. This is a contest to stack with an implied total of 48 points on the fast Arizona turf.

Murray is averaging 314.5 passing YPG with six total TDs over his last two meetings with Seattle, including a 360-yard eruption in his last home start against the Seahawks. He’s averaging 300.3 passing YPG and 5.7 YPC at home this year and is being forced to do even more with his legs now that DeAndre Hopkins (MCL) is out.

Fade: Matthew Stafford (DK: $6,700, FD: $7,400)

The Rams need a win to clinch the NFC West, but the 49ers need a win to make the playoffs and will be the more desperate team on Sunday. San Francisco is capable of guarding the Rams’ predictable offense, which revolves completely around Cooper Kupp.

The Niners rank second in DVOA rush defense and fifth in DVOA rush offense. They controlled 39:03 of possession and out-gained the Rams, 156-52, on the ground while earning a fifth straight win over the Rams in Week 10. Stafford won’t produce much if he doesn’t have the ball much.

Running Back

Best Play: Jonathan Taylor (DK: $9,300, FD: $10,200)

The Colts (-15) should absolutely smash the Jaguars this week along with the slim playoff hopes of the AFC teams praying for an upset in Jacksonville. The Jags just gave up 181 rushing yards to the Patriots and coughed up 273 rushing yards the week prior to a Jets team that still ranks 24th in rushing YPG (101.4) on the season.

Indy ranks first in DVOA rush offense and Taylor owns a commanding workload share with a league-high 317 carries and 90 red zone touches. He’s averaging 27 carries per game and 132.3 rushing YPG over his last four contests and has crushed the Jags for 184.5 rushing YPG at 7.2 YPC over his last two meetings with that tanking franchise.

Value Play: Samaje Perine (DK: $5,300, FD: $6,500)

With Joe Mixon (COVID) likely out and Joe Burrow (knee) likely to take a backseat even if he is active, the Bengals should ride Perine a lot at Cleveland. The Browns are sitting Baker Mayfield (shoulder) and have little to play for with the Bengals already named AFC North champs.

Cleveland is allowing 5.0 YPC and 132.3 rushing YPG over three consecutive losses, including 190 rushing yards to a poor Pittsburgh rushing attack. Mixon ranks third among RBs in carries (213) and fourth in red-zone touches (50). Now Perine, who is averaging 4.5 YPC this season, should step into a workhorse role.

GPP Play: Chase Edmonds (DK: $5,800, FD: $6,600)

If James Conner (heel) is cleared to play this Sunday, Edmonds will have very light ownership. Yet he could still prove to be a great tournament play if the Seahawks continue their offensive surge from last week and force this game to become a shootout.

Seattle has allowed the most receptions (116) and receiving yards (1,038) with 16 total TDs allowed to RBs this season. Edmonds has drawn 15 targets over his last two starts and owns the ninth-highest target share (13.4%) among backs this season. With Hopkins out, the Cardinals should utilize their receiving back early and often.

Fade: Dalvin Cook (DK: $7,800, FD: $8,700)

The Vikings have had a deflating season that ended in crushing fashion when Kirk Cousins (COVID) was ruled out around 48 hours before their showdown with the Packers. Coming off the COVID list himself, Cook plodded to just 13 yards on nine carries against a Green Bay defense that he’s shredded in recent years.

He now faces a Bears defense that has been his toughest matchup. Cook is averaging 67.2 rushing YPG at 3.5 YPC with two TDs over six career games against Chicago.

Wide Receiver

Best Play: Stefon Diggs (DK: $7,800, FD: $7,700)

The Bills other three main receivers have been in and out of the lineup for a variety of reasons, forcing Josh Allen to go back to his favorite target a little more often. Diggs has caught 23 of 42 targets over his last four outings and faces a Jets defense that he torched for a season-high 162 receiving yards on eight catches in Week 10.

The Jets allowed 405 passing yards last week against the Bucs and allows the second-highest completion rate (69.5%) on the season.

Value Play: Kristian Wilkerson (DK: $3,300, FD: $5,300)

There is little chance Wilkerson replicates his output (4-42-2TD) against the Jaguars in a much tougher matchup this week, but he’s worth his near-minimum price tag at DraftKings as long as N’Keal Harry is listed as a healthy scratch again.

With Harry and Nelson Agholor (concussion) out, the UDFA was promoted from the practice squad and showed immediate chemistry with Mac Jones, narrowly missing a third TD against the lowly Jags. Miami allows the fifth-fewest rushing YPG (97.3) at home, which is why 68% of yards from the opposition are coming through the air.

GPP Play: D.K. Metcalf (DK: $6,900, FD: $7,200)

The Seahawks have been trying to get Metcalf going for weeks now and finally accomplished that with the stud sophomore posting a 6-63-3TD line in a blowout win over Detroit last Sunday.

In a lost season, Seattle has little motivation to do anything but pump up it’s young stars, which now includes fourth-year RB Rashaad Penny along with Metcalf. Facing a Cardinals team that has coughed up the most receiving TDs (24) to WRs this season, Metcalf has the potential to repeat his multi-TD performance.

Fade: Cooper Kupp (DK: $9,700, FD: $10,000)

In the final week of the season, a defense might finally figure out how to contain Kupp. The Niners bottled him up for the better part of three quarters before he got to 11 catches for 122 yards in garbage time during a 31-10 loss in Week 10.

The 49ers are only allowing 179 passing YPG over their last three games and 209.4 passing YPG on the road. They rank sixth in adjusted sack rate (7.6%) and have elite coverage options with LB Fred Warner and safety Jimmy Ward anchoring their interior pass defense.

Tight End

Best Play: George Kittle (DK: $6,700, FD: $6,900)

Kittle is more of a GPP play at DraftKings following his second quiet game in a row, and more of a value option at this price tag at FanDuel. Playing him over Rob Gronkowski or Mark Andrews would be more about fading the matchups for those TEs, while assuming that the Rams will sell out to try and stop Deebo Samuel and the Niners’ elite rushing attack.

Kittle is averaging 87 receiving YPG at 15.8 yards per catch in his career against the Rams with a TD in three straight meetings. Jimmy Garoppolo (UCL) is practicing on a limited basis and his return would boost Kittle’s stock.

Value Play: Zach Ertz (DK: $5,300, FD: $5,600)

The Seahawks allow tons of throws underneath because they play a basic Cover-2 shell that is designed to bend without breaking. As a result, opposing TEs are grabbing 5.3 catches per game for 55 receiving YPG with nine TDs against Seattle this season.

Ertz has been consistent with 21 catches over his last three outings and he’s drawn 33 targets in those games with DeAndre Hopkins (MCL) unavailable. He might not be a consistent red zone presence, but he can be locked into Cash games with Kyler Murray keeping Arizona’s offense moving.

GPP Play: Pat Freiermuth (DK: $4,600, FD: $5,200)

After a one-game absence due to a concussion, Freiermuth caught five of six targets for 22 yards in a slugfest with the Browns. Now he’ll face a Ravens pass defense that can’t stop anyone while yielding a league-high 349.3 passing YPG over their last three contests. Baltimore has given up the fifth-most receiving yards (1,032) and eight TDs to TEs this season, while Freiermuth has garnered 15 red-zone targets over his last nine outings.

Fade: Mark Andrews (DK: $7,500, FD: $8,500)

Tyler Huntley has been locking onto his TE and he could be in line for another start with Lamar Jackson (ankle) unlikely to put it all on the line with the Ravens looking at a 3% chance to make the playoffs.

The Steelers are well aware of Huntley’s tendencies and have taken Andrews away throughout his career in purple, holding him to 37.8 receiving YPG without a TD over five career meetings. It will be very hard for him to meet value at this inflated price tag without a score, and Pittsburgh has only allowed four TDs to TEs all season.


Week 18 NFL Betting Odds

Nate Weitzer Avatar
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Nate Weitzer

Nate Weitzer is a successful DFS player at DraftKings and FanDuel with numerous tournament wins in NBA and NFL contests. He's been writing about DFS for several years, specializing in NBA picks and advice while continuing to build his bankroll across the daily fantasy industry. When he's not playing DFS, Weitzer is often covering high school sports in the greater Boston area for outlets such as The Boston Globe, or playing basketball himself. Follow Nate on Twitter @Nweitzer7.

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