Week 10 NFL Parlay Picks And Predictions

Written By Brian Sausa on November 10, 2021 - Last Updated on November 14, 2021

If you’re using online sportsbooks to bet on the NFL each week, there’s a good chance you’ve dabbled in parlays, which are the most popular bets outside of the standard moneyline, spread, and total. There is a huge range of variations across the betting market and below, we’ll offer a few examples as our Week 10 parlay picks.

If you’re into other bet types aside from parlays, feel free to check out some of our other weekly NFL betting content, which is listed below:


If you want to build a custom parlay, each sportsbook offers a huge range of markets and individual betting options for every game. If you’re looking for suggestions before building your own, keep on reading.

*odds are subject to change after writing*

NFL Parlays Week 10 | Cowboys vs. Falcons Picks For Same Game Parlay

Same game parlays are very popular, especially for standalone prime-time games. These bets can combine the result of the contest (ML, spread, and totals) with a variety of props to build a parlay of any odds they want, entirely constructed of selections from the same contest.

Below, we’ve combined the moneyline with an alternate total and several props to build an SGP for the Cowboys vs. Falcons matchup on Sunday, which comes out to +650 at DraftKings:

  • Dallas Cowboys -5.5 Alternate Spread
  • Over 46.5 Alternate Total
  • CeeDee Lamb 70+ Receiving Yards
  • Dak Prescott 300+ Passing Yards
  • Cordarrelle Patterson 40+ Receiving Yards

Dallas was just embarrassed at home by Denver and we’re banking on that being an aberration based on what we’ve seen this season. Missed extra points and two-point conversions are making six almost as key of a number as seven these days so when we build SGPs, we cover it if the odds don’t take too much of a hit.

In the definition of a bounceback game, we expect the Cowboys’ offense to look much more like the team we saw the first two months, and that means Dak Prescott needs to have a day. Prescott’s passes can go to anyone, but Lamb leads the team in targets and yards this season. It can be he or Cooper set up for a massive day at any time, but based on what occurred just before the Denver game, we’re comfortable with CeeDee getting back on the horse here.

Cordarrelle Patterson is an indispensable part of the Falcons’ offense and even though he’s basically the lead running back, his damage is done out of the backfield. He made a huge grab to set up a game-winning kick last week and he could be a factor once again in the short passing game.

NFL Week 10 Parlay Picks | Correlated Side & Total Parlays

For each individual NFL contest, sportsbooks also offer bettors the chance to link the moneyline or spread together with the over/under. Think of this as a sort of same-game parlay (SGP), just without any props.

Correlation bets featuring a team and the total are growing in popularity and are offered in diverse ways at sites like FanDuel and BetMGM, among others. Even if the site you’re using doesn’t offer them, you can still create an SGP that includes both elements at whichever numbers you choose.

Jacksonville Jaguars at Indianapolis Colts (1 p.m. ET)

Colts -6.5 & Over 45.5 (+150 or better): We aren’t expecting to see a repeat of Jacksonville’s shutdown effort against Buffalo in Week 9. It was impressive, but it was much more likely an aberration than something we should see for a second week in a row, especially against the best rushing offense in football.

The Colts’ offense is on fire, sparked by the running game and Jonathan Taylor behind a dominant offensive front. The Jags’ run defense has been decent enough but this unit is still 26th in yards per play and we’re fine with taking Indy to keep it going. The pace is slow for this offense but since we see them moving the ball

This spread is near double-digits so we’ve covered a key number and also gone with the over at a couple of points below the current total. With Trevor Lawrence and James Robinson on track to play and this one taking place in a dome, the Jags can do their part to just get this to 46. This one may look like the Colts-Jets game from last week by the end, albeit they won’t score 75 combined points.

Tampa Bay Buccaneers at Washington (1 p.m. ET)

Tampa Bay Buccaneers -9.5 & Over 47.5 (+180 or better): The last time these two teams met, it was the opening round of the NFC playoffs and the first step on Tampa’s run to the Super Bowl. This time, both are coming off bye weeks with the Bucs in first place and the WFT in dead last in the NFC East.

We’ll keep the 9.5-point spread since this game features the No. 1-ranked DVOA offense against the 30th ranked unit, plus the WFT defense is 25th in yards per play and dead last on third down.

Tampa’s run defense is elite but its pass defense isn’t and by virtue of leading most of the game, Washington is capable of scoring enough points on this group to get into the high 40s and secure this parlay for a decent payout.

Week 10 NFL Parlay Picks | The Three Teamer

There is so much variety offered that it’s hard to settle on a parlay strategy at some points. One thing we’d recommend is limiting bets to two or three sides, rather than four, five, or six. While the payouts won’t be as juicy, these wagers just have a much better chance of winning.  This week, we’re getting +341 odds at FanDuel Sportsbook for the following parlay:

  • Philadelphia Eagles +3 
  • Cleveland Browns +3.5 alternate line
  • Chiefs-Raiders Over 45.5 Points Alternate Total

Here, we’ve got a spread, an alternate spread, and an alternate total. There are plenty of people who warn against teasing or using alternate lines for totals in the NFL, but this can also be done on a case-by-case basis. You can also build any bet you want, so it doesn’t need to be this one.

We’ve been waiting on positive regression from this Chiefs offense and it just hasn’t really come. Are they due for a breakout, or are they just not at that level of explosiveness anymore? Maybe it’s a combination of both, but we are leaning toward the former in Las Vegas.

The Raiders are very good against the pass but porous against the run. Kansas City moving it easily on the ground, even if they don’t run much, will make things infinitely easier for Mahomes and the offense. We already know Kansas City’s defense is terrible, so moving this one down by a touchdown feels safe.

The Browns are just barely an underdog against New England and we think they win outright. But by crossing over a key number of three, we guard against a close loss in a matchup that may not be incredibly high-scoring.

As for Philadelphia, the Broncos are riding high after a win over the Cowboys but we look at the Eagles’ performance against the Chargers with some positives as well. Philly should be able to run the ball on Denver, who we are betting won’t put up a repeat showing of what we saw against Dallas based on the underlying numbers.

There are so many options out there, go take your NFL knowledge and try any number of combinations until you find a bet you like. Best of luck in Week 10.

Week 10 NFL Betting Odds


Parlays are bets which consist of two or more selections, resulting in the odds being boosted higher than you’d see from a typical straight bet. The potential to win much more than you risk is one of the reasons why parlays are so popular.

Exact parlay odds depend on multiple factors including the number of selections and the exact lines of each one, but all parlays will feature enhanced odds in some fashion. Remember that all legs of your parlay need to win for you to receive the full payout, and a push will remove the selection and keep the parlay alive.

You can include moneylines, spreads, totals, and even props in many cases, and bettors can choose to link together just two sides, or up 12 or more depending on the sportsbook. Parlays are wholly customizable, meaning bettors get to choose how big they want the odds to go, how many sides will be included, and how difficult to make each leg of the parlay.

While some bettors want high odds and a huge payday, just like you see on social media. But just because the occasional big wins are what you see go viral, they are closer to the exception and not the rule.

The way to establish consistency is to have just two or three sides and avoid chasing astronomical odds. Of course, it’s fine to take your shot at a massive payout as well, but be sure to only risk money you’re prepared to lose.

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Brian Sausa

Brian Sausa is a longtime sports content creator with extensive betting experience and knowledge of the industry. A journalism graduate with a ranging sports background, Brian has been employed by multiple professional leagues including MLB, MiLB, and the NHL.

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