Week 6 NFL DFS DraftKings Picks & Lineups

Five weeks of the season are in the books, and we’re back with a full slate of NFL DFS games at DraftKings. We’re listing our NFL DFS best picks at quarterback, running back, wide receiver, and tight end to target in Cash and GPP lineups.

Please note the advice below is relevant for daily fantasy purposes and slanted toward tournaments. A player or team might be better or worse from a fantasy perspective than in real life due to matchup, price, and lots of other factors. This is important to consider when constructing a roster. Injuries can also play a huge role in NFL DFS on a weekly basis. So always, always check the injury reports when playing an NFL slate.

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Best Week 6 NFL DFS Quarterbacks

Andy Dalton vs. PIT ($6.3k DraftKings) 

The Bengals might be good this year, and Dalton has a lot of weapons to work with, what with the emergence of Joe Mixon and the continued dominance of A.J. Green. This week, they are home favorites against the Pittsburgh Steelers, a team that looked to be back on track last week after dropping 41 points. But the Bengals are playing much better football, with a 4-1 record, and Dalton is averaging more than two passing touchdowns a game. The Steelers rank 31st against QBs, and Vegas has this game at an Over/Under of 53. If they’re going to win, the Bengals will need Dalton in some capacity. The matchup benefits are just an additional upside.

Matt Ryan vs. TB ($6.8k DraftKings)

Ryan and the Falcons looked horrible against the Steelers last week, and they are struggling to properly allocate touches across their talented roster. But they’re playing the Bucs this week, a team whose defense ranks dead last in DvP against the quarterback. Ryan has had two bad weeks this season, and both those games came on the road. Today, he’ll play at home, where he’s earned at least 32 DraftKings points in each of his three starts. There is, of course, some blowout risk here, but Ryan should get his fair share of Atlanta’s 30+ implied total. And he’s got upside if the Buccaneers offense can hang, which it’s been able to do at times this year.

Baker Mayfield vs. LAC ($5.5k DraftKings)

Welcoming the Los Angeles Chargers to Cleveland, Mayfield may find himself in an advantageous spot against a defense ranked a below-average 21st against the position. If you don’t buy into the “West Coast team traveling East of Denver” narrative for home quarterbacks, then try this. Since taking the reins, Mayfield has thrown for more than 300 yards on average across his two starts. He also has three passing touchdowns, and the Browns are home underdogs, suggesting that, at some point, they’ll likely play from behind. Cleveland is having a weird season, but Mayfield looks like he could be legit in certain matchups. Coming off a 22-point DraftKings performance with just one passing touchdown, I like the rookie’s floor/ceiling combo at this price point.

Cash Game Options: Jameis Winston, Cam Newton, Kirk Cousins


Best Week 6 NFL DFS Running Backs

Marshawn Lynch vs. SEA ($5.3k DraftKings)

Lynch bombed last week against a tough LA Chargers defense, but he’ll face off against his former team this weekend. The Seattle Seahawks’ run game has floundered since Lynch’s departure, and something tells me that one-yard-slant-turned-interception in Lynch’s last Super Bowl appearance doesn’t sit well with the longtime stud. With the narrative behind him, Lynch should be able to turn in one of his better performances of the season against an average Seahawks run D (17th DvP). He’s averaged 12.2 DraftKings points per game this season but is just a few weeks removed from his last home start, a 21.7 DK-point effort against the Browns. While the narrative weighs heavily in the decision to roster Lynch, the fact of the matter is, he simply looks good this season. This week, he should once again be a bright spot in an offense struggling to find an identity.

Joe Mixon vs. PIT ($7.5k DraftKings)

When you’re paying up for a running back, it really helps soften the salary blow if he can contribute in both the rushing and the passing game. Historically, those types see massive salaries (like Todd Gurley’s $10.0k this week). Mixon, meanwhile, comes in at a 25 percent discount to Gurley while still capable of contributing in multiple categories. The second-year back looks like a legitimate contender for the next big thing at the position, and the two 20+ DK point performances over his past two (full) games certainly help support that, if only in the near term. The Steelers rank fifth against opposing running backs, but there is at least a marginal possibility that Mixon, at this price, is somewhat matchup proof. If Gurley’s salary makes you uncomfortable (and it should), take the massive upside Mixon can offer as a home favorite in a game that should not be low on scoring.

Ezekiel Elliott vs. JAX ($7.0k DraftKings)

While the Jags rank sixth against opposing RBs, and the Dallas offense is in shambles, Elliott makes an intriguing play due to his workload. Elliott will be in line to see upwards of 30 touches this week, as Dak Prescott should struggle against this stout defense. Last week, the Cowboys’ premier running back had three red-zone carries and three red-zone targets. Though he failed to convert any into scores, it’s clear the Cowboys are going to have a tough time scoring without the ball in Elliott’s hands. At $7.0k, he’s a great value play if you’re only looking at volume. Sure, the matchup dings his upside a bit, but Elliott is one of the few backs in this league with multi-touchdown upside just about every week.

Cash Game Options: Nyheim Hines, T.J. Yeldon, Melvin Gordon, David Johnson


Best Week 5 NFL DFS Wide Receivers

Antonio Brown @ CIN ($8.7k DraftKings)

Brown managed over 100 yards and two touchdowns last week, the first time he had racked up either 100 yards receiving or multiple touchdowns this season. The trouble in Pittsburgh looms large with Le’Veon Bell still missing, but Brown and Roethlisberger appeared to get back on the same page in Week 5. Week 6 will carry even higher stakes against a Bengals team with just one loss on the season. Whether the Steelers win or lose, Brown will get looks, and he may still be in a buy-low spot given how drastically different reality has been from expectations this season. Look, you can believe last week was a fluke and he’s just not that good without the third B to take off some pressure. I don’t believe that.

DeSean Jackson @ ATL ($5.9k DraftKings)

Over the years, Jackson hasn’t lost his big-play ability. That’s certainly the case this year, as he has two games with fewer than seven points, one game with just under 20 DK points, another with 25.9 DK points, and his Week 1 performance yielded 34.6 DK points. This week, he’ll attempt to scorch this Falcons defense, just like Antonio Brown did last week (with 100+ yards and two touchdowns). The Falcons rank 27th against wide receivers, and Jackson will need to be part of the gameplan if they expect to compete as home underdogs. He’s affordable while offering arguably more upside than anyone at sub-$6k.

Julio Jones vs. TB ($7.9k DraftKings)

As much as I hate calling out AB and Julio, the fact is Brown emerged last week after being quiet for several. And Julio seems unable to carve out a meaningful share of work in this offense. But the real reason I like him is simple. If he can’t do it against the 31st ranked (vs. WR) Tampa Bay Buccaneers, then don’t worry about rostering him the rest of the season. Sure, he’s a bit of an obvious play when just isolating the matchup, but his weak returns over the first 1.5 months of the season should keep ownership down. And he isn’t exactly cheap. But if you think Julio Jones is the same Julio Jones that we’ve always known, then you should feel good about rostering him.

Amari Cooper vs. SEA ($5.2k DraftKings)

Reaching deeper into the bargain bin, we find another potentially elite receiver who’s fallen on hard times. Cooper’s career has been tough to follow as his glimpses of greatness are often overshadowed by drops and, frankly, his disappearing from offensive game plans. That hasn’t changed in the Jon Gruden 2.0 era: Cooper has scored four DraftKings points or fewer in three of five games while scoring more than 24 in each of the other two. This week, he’ll face a Seahawks secondary that was average before Earl Thomas was lost for the season. There’s no reason he shouldn’t find a way to eat as the Raiders enter Sunday’s matchup as road underdogs. They’ll likely try to lean on Lynch, but Cooper gains some upside advantage given the Raiders will likely spend at least a portion of the game playing from behind. At this price, take the 20-30 point upside from Amari.

Ryan Grant @ NYJ ($4.6k DraftKings)

The Colts will be without T.Y. Hilton this week, and it’s not like Eric Ebron can catch all of the touchdowns. I expect a bump in Ryan Grant’s work as a result of Hilton’s absence, and Grant has shown himself moderately capable of producing with more work. Last week, the wideout was targeted nine times by Andrew Luck, reeling in six of those for 58 yards. That doesn’t instill a ton of confidence, but with double-digit target upside this week, at just $4.6k, Grant seems poised to break out. The Jets rank 28th against the wideout position, and Luck will likely find himself playing from behind, which is just a way of life for the Indianapolis Colts these days. Grant offers immense upside for a guy cheaper than three main-slate tight ends (and that doesn’t include Kelce nor Gronk).

Cash Game Options: Tyler Boyd, Adam Thielen, Keke Coutee, Mike Evans, Juju Smith-Schuster, John Brown, Chester Rogers


Best Week 6 NFL DFS Tight Ends

Eric Ebron @ NYJ ($5.4k DraftKings)

Speaking of Eric Ebron, defenses are having a really tough time defending this guy. He’s a tight end who can move more like a wide receiver (as we saw with his second touchdown last week), and he has five touchdowns on the season, proving himself as Andrew Luck’s greatest weapon. The matchup this week is tough against a Jets team ranked number one against the position. But we’re five weeks in, and Ebron’s role in this offense is undeniable. With Gronk and Kelce not on the main slate, upside at tight end will be hard to find. Ebron’s athleticism at least suggests that the matchup should be weighted less than his recent successes, thus justifying him as a TE1 in GPPs. Ebron has missed some practice this week, so be sure and check in on his status prior to Sunday.

Vance McDonald @ CIN ($3.4k DraftKings)

In his limited time in Pittsburgh, McDonald has impressed, if only because of the stiff-arm that put Chris Conte into the ground a few weeks back. McDonald has two double-digit DK point performances over his last three games, and the Steelers need weapons with Bell remaining in holdout mode. The Bengals rank 24th against opposing tight ends, lighting the way for McDonald to contribute in a meaningful way once again.

Cash Game Options: Jared Cook, Cameron Brate, Austin Hooper, Jordan Reed


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