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The NFL calendar turns to Week 6 with the Giants hosting the Eagles in an NFC East rivalry tilt this Thursday night. For this game and every other primetime contest, we’ll break down the sports betting lines and recommend where to place your bets at DraftKings Sportsbook888 Sportsbook, and FanDuel Sportsbook.

This advice is also relevant for daily fantasy contests on sites such as DraftKings and FanDuel and can be helpful in seasonal fantasy leagues as well.

Keep an eye on injury news right up until kick off since things can change quickly in the NFL. Any player listed as questionable may see limited action or not suit up at all if they don’t respond well in warm-ups.

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Week 6 Thursday Night Football Betting 

Philadelphia Eagles (22.75) at New York Giants (21.25) NJ Odds 

DraftKings Sportsbook Odds: Eagles -3, 44 total 
888 Sportsbook OddsEagles -3, 44 total
FanDuel Sportsbook Odds: Eagles -2.5, 43.5 total
BetStars Sportsbook OddsEagles -3, 44 total

A tough divisional matchup on short rest likely means some unpredictable things will happen. This contest has a modest 44-point total since the Eagles have yet to crack 30 points this season and the Giants scored 30 for the first time in 27 games last Sunday.

Philadelphia’s defense remains its strength, ranking sixth in DVOA rush defense while allowing the sixth-fewest PPG (20.8) this season. Saquon Barkley should be able to do damage as a receiver considering the Eagles have allowed 30 receptions to RBs through five games.

While Haloti Ngata (calf) is questionable and Timmy Jernigan (back) remains out, the Eagles still have Fletcher Cox to lead one of the best defensive lines in football. The Giants’ offensive line has improved since struggling RT Ereck Flowers was released. Still, Eli Manning should be under fire in this game. The 37-year-old is absolutely awful when pressured.

However, against the Eagles, Manning has only been sacked twice over his last four meetings. He also averaged 400 YPG with 6 TD and 2 INT over two meetings with Philly last season.

Philadelphia’s weakness was on the back end early in the season, specifically, LCB Jalen Mills. With Rodney McLeod (knee) out for the year, rookie Avonte Maddox stepped in and played every snap at free safety last week. Maddox played well, and Mills improved despite the routinely big lines put up by Adam Thielen and Stefon Diggs.

The Giants would be wise to move Odell Beckham Jr. around the formation and use him similarly to how the Vikings used Diggs, on short screens and shallow routes. “OBJ” has massive upside in what should be a pass-heavy game plan. He’s dominated with 24 catches for 275 yards and 4 TD over his last three meetings with Philly. He also drew at least 10 targets in each of those games.

With the public gravitating toward Beckham, playing Sterling Shepard could pay off in Showdown DFS contests on DraftKings and FanDuel. With Evan Engram (knee) out, targets should flow to Shepard. Russell Shepard and Cody Latimer should also get opportunities over the middle of the field although both are far from reliable.

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The Eagles have won seven of their last eight over the Giants and covered the spread in eight of their last 11 trips to MetLife Stadium. Philadelphia is 4-0 on Thursdays under HC Doug Pederson. Then, Carson Wentz is trending in the right direction after showing a little rust in his first couple starts off ACL surgery.

At RB, a season-ending injury to Jay Ajayi (knee) throws a wrench in the Eagles’ running game. But they still should be able to attack a Giants team that ranks 25th in DVOA rush defense. Wendell Smallwood split snaps evenly (29) with Ajayi last week. He’s likely to experience a similar timeshare with Corey Clement (quad), who returns from a two-game absence.

While Alshon Jeffery is getting healthier and led all receivers with 54 snaps last Sunday, he was virtually erased by Xavier Rhodes and could struggle against Janoris Jenkins this week.

The Giants’ stingy secondary has only allowed 6 TD receptions this season, but four of those have gone to RBs (most in the NFL). That gives Clement more upside than Smallwood as the superior receiving back.

Look for Philadelphia to attack the middle of the Giants’ defense with backs and TE Zach Ertz, arguably the safest play on the showdown slate. Rookie TE Dallas Goedert could also produce against a Giants team that ranks 32nd in defending passes over the middle third of the field per Football Outsiders.

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Philadelphia’s offense is a long ways from its Super Bowl form. The Eagles have scored on just one third (19-of-57) of their drives this season, but the Giants have given up points on 50 percent of defensive possessions. That’s the second-highest rate in the league.

The left side of the Eagles’ offensive line is messy with LT Jason Peters (quad) working his way back and Isaac Seumalo replacing starting LG Stefen Wisneski last week. Eagles RT Lane Johnson (ankle) is unlikely to play tonight.

While the Giants are tied with the Raiders for the fewest sacks (6) this season, they could get their best pass rusher back in Olivier Vernon (ankle). We could see the Giants dormant pass rush come alive to keep the Eagles passing attack in check.

These two teams have averaged a combined 54.6 PPG while going over the implied total in five consecutive meetings. That explains why over 75 percent of bets are coming on the Over. However, only 60 percent of the money is on the Over, as the sharps analyze the data.

The Giants rank 26th in pace of play during neutral situations, and the Eagles rank 23rd. Philly is running the fifth-most plays per game (69.4), but the Giants are running the fifth-fewest (60.4). Finally, the teams rank 29th and 30th in average starting field position.

Taking Philadelphia (-150) on the moneyline is the safest option because of their superiority at the line of scrimmage and the clutch factor with Wentz. The public is willing to take the Eagles (-3) with approximately 60 percent of bets and 60 percent of money coming in on that side of the spread.

Teasing the Eagles (-3) with the Under would be a good way to bank on that defensive superiority. The total seems relatively unpredictable given the boom-bust nature of an Eli Manning-led offense. We advise taking the Eagles to bounce back after a slow start.

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