The NFL is rolling, and injury news continues to create implications in seasonal and daily fantasy football as well as in sports betting markets. Every week, we’ll bring you a list of the key injuries that could impact sports betting odds and DFS contests on sites such as DraftKings and FanDuel.
Note that players who fail to practice on Thursdays and/or Fridays leading into games may be listed as questionable but are in actuality closer to doubtful. Be sure to check back each afternoon to see if key players did any work in practice for clues as to their eventual status.
NFL coaches are famous for being taciturn when it comes to injuries, so nothing is set in stone when trying to predict how a player will perform, even if active.
This article will be updated several times throughout the week, so check back often. Here are the key injuries to watch ahead of Week 6.
Deshaun Watson, Houston Texans (Chest, Questionable)
Deshaun Watson took several hard hits during an OT win over Dallas Sunday night and is listed as day-to-day with a chest injury. Brandon Weeden would be asked to start if Watson can’t play Sunday against the Bills.
Ryan Tannehill, Miami Dolphins (Shoulder, Questionable) – Updated 10/12
Ryan Tannehill is expected to play through a shoulder injury. The Bears defense should be all over him with the best pass rush in the league.
Jay Ajayi, Philadelphia Eagles (Knee, Out)
Jay Ajayi suffered a torn ACL at some point during Sunday’s loss to Minnesota. He’ll miss the rest of the season. Wendell Smallwood and Corey Clement (quad) are expected to share lead back duties with Darren Sproles (hamstring) mixing in on passing downs once he returns to action.
Devonta Freeman, Atlanta Falcons (Foot, OUT) – Updated 10/12
Devonta Freeman suffered a foot contusion while attempting to work his way back from an MCL sprain. He won’t play in Week 6, putting Tevin Coleman on the radar as a potential RB1 with Ito Smith mixing in for touches against Tampa’s league-worst scoring defense.
Leonard Fournette, Jacksonville Jaguars (Hamstring, Out)
Leonard Fournette has already been ruled out of a Week 6 matchup with the Cowboys. T.J. Yeldon will draw another start and see a huge workload with Corey Grant (foot) likely out for the season with a Lisfranc injury. The Jaguars have signed Jamaal Charles to serve as a change-of-pace back.
Sony Michel, New England Patriots (Knee, Questionable) – Updated 10/11
Sony Michel was spotted riding a stationary bike while the rest of the Patriots warmed up Thursday. He should be good to go by Sunday night to face the Chiefs’ league-worst rush defense, but if he’s out expect James White to see an even heavier workload.
Matt Breida, San Francisco 49ers (Ankle, Questionable) – Updated 10/13
Matt Breida suffered a sprained ankle during Sunday’s loss to the Cardinals, and HC Kyle Shanahan says he’s a game-time decision for Monday night’s matchup at Green Bay. Alfred Morris may be asked to carry the load against the Packers.
Chris Thompson, Washington Redskins (Ribs, Questionable) – Updated 10/11
Both Chris Thompson and Adrian Peterson (shoulder) were injured while attempting to catch passes from Alex Smith Monday night. Thompson was limited in practice Wednesday and if he is out in Week 6, Kapri Bibbs would likely handle passing downs. Peterson said he plans to play through a dislocated shoulder. Thompson also seems likely to play after practicing on a limited basis.
Isaiah Crowell, New York Jets (Ankle, Questionable) – Updated 10/13
After running wild in a win over the Broncos, Isaiah Crowell missed practice on Wednesday and Thursday. He’s a game-time decision for Sunday’s matchup with the Colts Trenton Cannon could have a role on early downs, but Bilal Powell should see the bulk of the work if Crowell isn’t full strength.
Dalvin Cook, Minnesota Vikings (Hamstring, Questionable) – Updated 10/11
Dalvin Cook practiced in full on Thursday and appears to be ready to return in a juicy matchup against the Cardinals this Sunday.
Lamar Miller, Houston Texans (Chest, Questionable) – Updated 10/10
Lamar Miller was active but didn’t play last Sunday night. Alfred Blue should continue to see steady work even though Miller said he’s “definitely” going to play Sunday. Expect a 50-50 split until D’Onta Foreman (Achilles) returns in Week 7 to create a full-blown committee.
Out for Extended Period: Le’Veon Bell, Rex Burkhead, Jerick McKinnon, Derrius Guice, Rob Kelley, Jeremy Hill
Brandin Cooks, Los Angeles Rams (Concussion, Questionable) – Updated 10/13
Both Brandin Cooks and Cooper Kupp (concussion) were knocked out of Sunday’s win in Seattle, but both were cleared and are expected to start Sunday at Denver.
Marquise Goodwin, San Francisco 49ers (Hamstring, Questionable) – Updated 10/13
While Marquise Goodwin is expected to return on Monday night, Dante Pettis (knee) is out indefinitely and Pierre Garcon (shoulder) is questionable. Trent Taylor (back) sounds iffy and Matt Breida (ankle) is a game-time decision. That leaves TE George Kittle to carry the offense in a tough spot at Green Bay. The Packers (-9.5) may be able to cover that lofty spread.
Randall Cobb, Green Bay Packers (Hamstring, Questionable) – Updated 10/12
Both Randall Cobb and Geronimo Allison (hamstring) are questionable for Monday night and were rehabbing on the practice field Friday. Rookie Marquez Valdes-Scantling has established himself as a trusted target for Aaron Rodgers and will step up if either WR is inactive.
Chris Hogan, New England Patriots (Thigh, Questionable) – Updated 10/12
Chris Hogan missed practice Thursday and could begin to fall out of the Patriots crowded rotation of receivers if he isn’t going full speed by Friday. Josh Gordon appears poised for an elevated workload in a potential shootout against KC.
T.Y. Hilton, Indianapolis Colts (Hamstring, OUT) – Updated 10/12
T.Y. Hilton won’t play in Week 6 and is listed as week-to-week. Chester Rogers will benefit most from his absence.
Paul Richardson, Washington Redskins (Knee, Questionable) – Updated 10/12
Josh Doctson (heel), Jamison Crowder (ankle) and Vernon Davis (knee) are all questionable for a Week 6 matchup against the Panthers. Paul Richardson would see a healthy dose of James Bradberry even if he’s active.
Rashard Higgins, Cleveland Browns (Knee, Questionable)
Rashard Higgins departed Sunday’s overtime win with a sprained MCL. He was third in line for targets behind Jarvis Landry and Antonio Callaway. His absence could funnel more looks towards TE David Njoku.
Out for Extended Period: Marqise Lee, Mack Hollins, Mike Wallace, Pharoh Cooper, Curtis Samuel, Rishard Matthews, Bruce Ellington
Greg Olsen, Carolina Panthers (Foot, Questionable)
Greg Olsen is expected to return in Week 6 as the Panthers face Washington on the road.
Austin Seferian-Jenkins, Jacksonville Jaguars (Core, Out)
After ineffectively trying to play through the injury, “ASJ” will be sent to injured reserve with a core injury. Niles Paul will be asked to step up as a receiving TE for the Jags.
O.J. Howard, Tampa Bay Bucs (Knee, Questionable) – Updated 10/12
O.J. Howard has been practicing with a heavy brace on his knee, but got in a full practice on Friday. If he’s out, Cameron Brate would see more snaps against the Falcons horrendous defense this Sunday.
Tyler Kroft, Cincinnati Bengals (Foot, OUT)
Tyler Kroft started for Tyler Eifert but suffered a foot injury and was forced from the game last Sunday. C.J. Uzomah will see more snaps in Week 6.
Jack Doyle, Indianapolis Colts (Hip, OUT) – Updated 10/12
Jack Doyle will miss a fourth consecutive game. In his stead, Eric Ebron has thrived with Andrew Luck feeding him the ball.
Virgil Green, Los Angeles Chargers (Ribs, Questionable)
Virgil Green is primarily a blocking TE. His absence wouldn’t affect much other than freeing up a few more targets for the soon-to-be-retired Antonio Gates.
Out for Extended Period: Tyler Eifert, Delanie Walker, O.J. Howard, Hunter Henry, Jake Butt, Will Dissly
Taylor Lewan, Tennessee Titans (Foot, Questionable)
The Titans’ weak rushing attack could struggle without a valuable lineman in Taylor Lewan, who was forced from Sunday’s loss with a foot injury.
Kelechi Osmele, Oakland Raiders (Knee, Questionable) – Updated 10/12
The Raiders sent tackle Donald Penn (groin) to injured reserve and now starting LG Kelechi Osmele is doubtful. That’s a serious downgrade for Marshawn Lynch ahead of a revenge game against Seattle.
Billy Price, Cincinnati Bengals (Foot, Questionable)
Rookie center Billy Price is likely to miss at least one more week with his foot injury.
Laremy Tunsil, Miami Dolphins (Concussion, Questionable)
The Dolphins lost starting center Daniel Kilgore for the season to a torn tricep last week. Plus, starting LT Laremy Tunsil is now in the league’s concussion protocol.
Josh Wells, Jacksonville Jaguars (Groin, Questionable)
Josh Wells was filling in at LT after the Jaguars lost Cam Robinson (knee) for the season. With Wells out, Josh Walker moved from RG to tackle and struggled to protect Blake Bortles.
Garett Bolles, Denver Broncos (Ankle, Questionable)
The Broncos were already missing RT Jared Veldheer (knee) and lost starting LT Garett Bolles to an ankle injury in Week 5. Denver will have a hard time blocking the Rams’ strong front seven if both tackles are out.
Riley Reiff, Minnesota Vikings (Foot, OUT)
Vikings starting RT Riley Reiff will miss Sunday’s cake walk against the Cardinals.
Out for Extended Period: Isaiah Wynn, Travis Frederick, Cam Robinson, Jon Halapio, Andy Levitre, Matt Kalil, Daryl Williams, Seantrel Henderson, A.Q. Shipley
Cameron Wake, Miami Dolphins (Knee, Questionable) – Updated 10/12
Cameron Wake and Andre Branch (ankle) appear doubtful to face the Bears this Sunday.
David Irving, Dallas Cowboys (Personal, Questionable)
He is eligible to return from suspension, but David Irving is dealing with personal issues that may keep him off the field in Week 6. If he plays, the Cowboys D/ST will be a stronger option at home against the Jaguars.
Denico Autry, Indianapolis Colts (Hamstring, Questionable)
The Colts lost Denico Autry, LB Anthony Walker (concussion) and safety Clayton Geathers (concussion) during a blowout loss to New England last Thursday. Those players will have extra time to clear protocol before facing the Jets Sunday.
Out for Extended Period: Joey Bosa, Everson Griffen, William Hayes, Muhammad Wilkerson, Timmy Jernigan, Ryan Glasnow, Vita Vea, Tyquan Lewis
Sean Lee, Dallas Cowboys (Hamstring, Questionable)
The Cowboys’ best defensive player may miss another week. This would further boost the stock of T.J. Yeldon. However, Jaylon Smith is playing very well in replacement of Lee.
Justin Houston, Kansas City Chiefs (Hamstring, Questionable)
Justin Houston was forced to leave Sunday’s win with a hamstring issue and could miss multiple weeks. He’s the Chiefs’ best pass rusher, and his absence would be a huge boost for Tom Brady and the Patriots’ ample weapons on Sunday night.
Wesley Woodyard, Tennessee Titans (Shoulder, Questionable)
With Wesley Woodyard and starting safety Kenny Vaccaro (elbow) out, the Titans struggled to stop the Bills running game in Week 5. Javorius Allen and Alex Collins would benefit if Woodyard is out in Week 6.
Olivier Vernon, New York Giants (Ankle, Questionable)
The Giants OLB may suit up for the first time this season. Olivier Vernon could help contain Zach Ertz and the Eagles underneath passing attack while pressuring Carson Wentz.
Nick Perry, Green Bay Packers (Ankle, Questionable)
The Packers’ two-down LB is questionable for a Week 6 date against the 49ers. This could make their struggling defense even more vulnerable.
Out for Extended Period: Jake Ryan, Deion Jones, Dominique Easley, Kyzir White, Josh Martin
Buster Skrine, New York Jets (Head, OUT) – Updated 10/13
Already missing top CB Trumaine Johnson (quad), the Jets may also be without excellent slot CB Buster Skrine against the Colts.
William Jackson, Cincinnati Bengals (Knee, Questionable) – Updated 10/13
If William Jackson can’t play, Antonio Brown sees a big boost in value.
Micah Hyde, Buffalo Bills (Toe, Questionable)
Both Micah Hyde and fellow safety Rafael Bush (shoulder) are dealing with injuries this week. With Tre’Davious White likely shadowing DeAndre Hopkins, Keke Coutee could have another big day in the slot against a hobbled secondary.
Jaire Alexander, Green Bay Packers (Groin, Questionable)
With Jaire Alexander out and Kevin King (chin) forced to leave Sunday’s loss, the Packers couldn’t cover Kenny Golladay. Green Bay is lucky to face a 49ers receiving corps that’s also ravaged by injuries this Monday.
D.J. Hayden, Jacksonville Jaguars (Toe, Questionable)
D.J. Hayden has missed two straight games. The Jaguars will hope he can return in Week 6 to cover Cowboys slot receiver Cole Beasley.
Trae Waynes, Minnesota Vikings (Concussion, Questionable)
Trae Waynes was out in Week 5 but should be able to clear the league’s concussion protocol by Sunday.
Eric Murray, Kansas City Chiefs (Leg, Questionable)
The Chiefs have been badly missing safety Eric Berry (heel) and lost two safeties during Sunday’s win in Eric Murray and Armani Watts (groin). They’ll need to get healthy in the secondary to have any hopes of stopping the Patriots Sunday night.
Adam Jones, Denver Broncos (Leg, Questionable)
The Broncos were already missing Tramaine Brock (thigh) and were forced to give rookie Isaac Yiadom steady run with Adam Jones out. The Jets threw all over that struggling unit, and life won’t get much easier with the Rams coming to town Sunday.
Out for Extended Period: Jason Verrett, Eric Berry, Patrick Robinson, Kenny Vaccaro, Vernon Hargreaves, Ross Cockrell, Phillip Gaines, Byron Maxwell, Daryl Worley, Ricardo Allen, Keanu Neal
Caleb Sturgis, Los Angeles Chargers (Quad, Questionable)
The Chargers signed Mike Badgley to fill in at kicker while Caleb Sturgis rehabs a quad injury.