Week 5 NFL DFS DraftKings Lineups & Picks

One quarter of the season is in the books, and we’re back with a full slate of NFL DFS games at DraftKings. We’re listing our NFL DFS best picks at quarterback, running back, wide receiver, and tight end to target in Cash and GPP lineups.

Please note the advice below is relevant for daily fantasy purposes and slanted toward tournaments. A player or team might be better or worse from a fantasy perspective than in real life due to matchup, price, and lots of other factors. This is important to consider when constructing a roster. Injuries can also play a huge role in NFL DFS on a weekly basis. So always, always check the injury reports when playing an NFL slate.

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Best Week 5 NFL DFS Quarterbacks

Ben Roethlisberger vs. ATL ($6.9k DraftKings) 

This week, “Big Ben” takes the spot Brees had last week atop our DraftKings quarterback plays. Roethlisberger is at home where he’s always been a better version of himself. And he’s playing the Atlanta Falcons, a team that ranks 25th against the QB position in DK points allowed over their last 16 games. And last week, the Falcons allowed 37 points to the Cincinnati Bengals. That’s still a touchdown less than they allowed to the Saints the week before.

But why Ben? (Besides the fact that he’s at home.) Well, he’s played two pretty good defenses this year and two pretty bad ones. In his latest outing, he faced a solid Ravens defense that held him to 274 yards and one touchdown. The week prior, however, he torched the Tampa Bay Buccaneers for 353 yards and three touchdowns. Those totals pale in comparison to his Week 2 performance against the Chiefs in which Roethlisberger had three passing touchdowns on 452 passing yards. He’s a high-upside, high-floor play, but he’ll cost you.

Matt Ryan @ PIT ($6.6k DraftKings)

On the other side of the field, Matt Ryan is an intriguing play given he’s eclipsed 30 DraftKings points in three straight, and the Pittsburgh Steelers have allowed, on average, more than 29 points per game this season. Ryan is coming off a 419-yard, three-touchdown performance, and he’s working nicely with new additions Ito Smith and Calvin Ridley. While he failed to eclipse 10 DK points in his first start of the season, his first and only road game so far in 2018, Ryan has high upside. He’s riskier than Ben at home, but the Falcons QB has eight touchdowns and 793 yards over the past two weeks. You should feel confident about his ceiling in GPPs.

Blake Bortles @ KC ($5.5k DraftKings)

Bortles isn’t a guy fantasy players are used to relying on, but he’s got a great matchup against the Kansas City Chiefs this weekend. This Chiefs team has allowed nine passing touchdowns in four games, but they allowed three in each of the first two weeks of the season. Bortles has flashed upside this season, with 28.32 DK points last week and 36.58 in Week 2. Given the Chiefs’ defensive woes, and the likelihood that the Jags will have to play catchup in this one, Bortles will be the key to a Jacksonville win. Assuming he can be effective against a bad Chiefs defense missing many of their stars from 2017, Bortles offers value and opportunity. Leonard Fournette has already been ruled out, and Bortles is a full 70 pass yards and nearly one TD better per game when LF7 sits.

Cash Game Options: Matthew Stafford, Cam Newton, Russell Wilson

Best Week 5 NFL DFS Running Backs

Matt Breida vs. ARI ($5.7k DraftKings)

Breida has disappointed in back-to-back weeks after a 27.9-point performance against Detroit in Week 2. But this weekend against the Cardinals, a team ranked 31st against opposing RBs, the dual-threat RB should be able to get back on track. The Niners are home favorites (-4.5), meaning they’re expected to get ahead, but not by much. Breida provides a path to both running down clock while remaining competitive and, hopefully, scoring the football. Breida’s rushing touches should be expected to fall in the low teens, but he offers a solid floor due to his involvement in the passing game. With three catches in each of his past two games, he’ll have opportunity. He’s one of the only weapons in this weak San Francisco offense.

Christian McCaffrey vs. NYG ($8.0k DraftKings)

The New York Giants rank 26th in DvP against the RB position, which should help stomach the $8,000 you’ll have to dish out for McCaffrey. But it’ll probably be worth it. This NYG team did just surrender 44 DraftKings points to Alvin Kamara last week. The dual-threat is entrenched as the lead back in Carolina, and he’s getting work all over the place. In his last game, McCaffrey carried the ball 28 times for 184 yards. The week prior, he had 14 receptions on 15 targets. With so many ways to use him against a defense, McCaffrey is always guaranteed work. He’ll get some this weekend as the Panthers are 6.5-point home favorites.

Joe Mixon vs. MIA ($6.9k DraftKings)

Still carrying an injury designation, Mixon needs a quick check on Sunday before lineups lock. But assuming he is in, the second-year back is a very strong play against a Miami defense allowing the third-most DraftKings points to running backs over their last 16 games. They also just allowed Sony Michel to have a mini-breakout game, rushing for 112 yards and a touchdown last week. Before his injury in Week 2, Mixon looked exceptional: 25.9 DraftKings points in the opener. The Dolphins defense isn’t bad as a whole, but with the Bengals scoring 30 or more points in three of four games this season, the Cincy offense is operating on a very high level. Mixon is legitimately a contender to be an elite running back by the time this season is over. If he’s healthy, he’s worth a hard look in GPPs at this price.

Cash Game Options: Melvin Gordon, Todd Gurley, TJ Yeldon, James Conner 


Best Week 5 NFL DFS Wide Receivers

Julio Jones @ PIT ($8.5k DraftKings)

A sub-$9k Julio is always in play, especially this weekend against a Steelers team that isn’t stopping receivers (30th DvP). It is also expected to be a high-scoring game with an over/under of 57.5. Jones is coming off his second strong week of the season, in which he caught nine balls for 173 yards (10 catches for 169 yards in Week 1). However, he’s yet to catch a touchdown, mostly because Calvin Ridley has five over his last two games. But I say let the masses flock to Ridley. I expect Mike Tomlin will attempt to find an answer to the rookie. Ridley, plus the potential return of Devonta Freeman, gives this Steelers defense a litany of playmakers to contain. Jones should be able to reap the benefits of advantageous matchups in this one, and, with the high expected total, maybe he finally finds his way for six.

Juju Smith-Schuster vs. ATL ($7.5k DraftKings)

Ranking 26th against the WR position, Atlanta is expected to yield a lot of points to this Steelers team. And while James Conner is serviceable, the Steelers’ core offense is in the wide receiver duo of Antonio Brown and Juju Smith-Schuster. Unlike Atlanta, Pittsburgh is short on weapons without the third member of the Killer B’s, but Smith-Schuster has stepped up nicely, with 31 receptions and three 100-yard receiving games so far this season. Last week, he managed just 10 DraftKings points, which may scare away owners, and those just generally nervous about this shaky Steelers team. But Smith-Schuster provides real upside in a high-scoring contest against a defense that struggles against the position. Even at this elevated price, he has high ROI potential.

Keelan Cole @ KC ($4.9k DraftKings)

A few weeks ago, Cole seemed like a no-brainer waiver wire pickup. But his three targets last week paint a different picture. Still, he and Bortles had something, and there is very limited competition in the Jacksonville receiving corp, even with the apparent emergence of Donte Moncrief and Dede Westbrook (we’ve seen these blips on the radar before). Cole had 17 targets in Week 2 and three before falling off in Week 4. His ownership will be depressed as a result, but the matchup says Cole is squarely in play. The Chiefs are on a tear, and the Jags are three-point underdogs with a game over/under of 48.5. The Jags will likely play from behind in this one, and the Chiefs rank 19th against WR1 (and they allowed four touchdowns in the first two weeks against opposing wideouts). Any Jags player carries risk, but Cole’s salary makes him a worthwhile GPP salary-saving option, with upside if he gets upward of 10 targets again.

Stefon Diggs @ PHI ($7.0k DraftKings)

Diggs has had a sporadic season, with weeks of 26.3 DraftKings points and 38.9 DraftKings points to go with weeks of 14.1 and 5.6. Those latter scores didn’t get the job done, but the other two? That’s the upside you’re after with Diggs, and he has it this week against the Eagles. Philly ranks 31st in DVOA against WR2, and Diggs has double-digit targets in three consecutive weeks. His rapport with Kirk Cousins is real, and his share of this receiving game is meaningful, especially with the absence of Jerrick McKinnon and the battered state of Dalvin Cook. Diggs has high upside in this one, and he should be on your tournament radar.

Golden Tate @ GB ($6.7k DraftKings)

Tate broke out last week with 36.2 DraftKings points. He’ll be needed this week if the Lions hope to keep up with the Green Bay Packers and Aaron Rodgers. The Packers allowed 28.4 DraftKings points to Tate the last time they met back in 2016, and Tate has scored at least 20 DraftKings points in all but one game since. With over 100 receiving yards to go with two touchdowns last week on a very efficient eight receptions on eight targets, Tate appears to be making the most of the increased overall talent in this receiving corp with the emergence of Kenny Golladay. Expect the second-year man to take a step back, as Tate is still the guy at WR in Detroit.

Cash Game Options: Tyler Boyd, Adam Thielen, Antonio Brown, Taywan Taylor, Marvin Jones, Doug Baldwin 

Listen to “Episode 9: Week 5 DFS Picks, Value Plays & Fades” on Spreaker.

Best Week 5 NFL DFS Tight Ends

George Kittle vs. ARI ($5.4k DraftKings)

Kittle had a dominant week last week, the first with C.J. Beathard as the 49ers starter. The tight end racked up 27.5 DraftKings points a week after earning 14.9. This Niners offense is short on talent, and Beathard will likely be looking to his tight end in single coverage. Kittle has 15 targets over the past two weeks, which is a very reassuring amount for the tight end position. Take the targets and the upside in this one.

Zach Ertz vs. MIN ($6.5k DraftKings)

The Minnesota Vikings are struggling on defense right now while Zach Ertz is at the core of this Carson Wentz-led offense. The Philly tight end reeled in 10 of 14 targets last week, and he now has 47 targets on the season. The return of Alshon Jeffery didn’t hurt Ertz while the return of Wentz certainly has helped. The Philly TE has earned 36.5 DraftKings points over the past two weeks. He’s expensive, but Ertz has the upside you want in GPPs.

Cash Game Options: Vance McDonald, Kyle Rudolph, Travis Kelce


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