The NFL is rolling, and injury news continues to create implications in seasonal and daily fantasy football, as well as in sports betting markets. Every week, we’ll bring you a list of the key injuries that could impact sports betting odds and DFS contests on sites such as DraftKings and FanDuel.
Note that players who fail to practice on Thursdays and/or Fridays leading into games may be listed as questionable but are in actuality closer to doubtful. Be sure to check back each afternoon to see if key players did any work in practice for clues as to their eventual status.
NFL coaches are famous for being taciturn when it comes to injuries, so nothing is set in stone when trying to predict how a player will perform, even if active.
This article will be updated several times throughout the week, so check back often. Here are the key injuries to watch ahead of Week 5.
Marcus Mariota, Tennessee Titans (Elbow, Questionable)
Marcus Mariota continued to play through an elbow injury and seemed to finally find his rhythm down the stretch in an overtime win over the Eagles. This week, capable QB play from the Titans would be a huge boost for Corey Davis, Tajae Sharpe, and Taywan Taylor.
Leonard Fournette, Jacksonville Jaguars (Hamstring, Out) – Updated 10/3
Leonard Fournette returned to action in Week 4 but rushed for just 30 yards on 11 carries before departing with a setback to his hamstring injury. He could miss multiple weeks. In his stead, T.J. Yeldon will step in as the Jaguars’ lead back and he draws a fantastic matchup against the porous Chiefs defense this Sunday.
Devonta Freeman, Atlanta Falcons (Knee, Questionable) – Updated 10/3
Devonta Freeman is practicing this week and is expected to return for the 1-3 Falcons this Sunday. Ito Smith will likely fall out of the rotation and Tevin Coleman will resume his duties as the 1B back in Atlanta’s offense.
Joe Mixon, Cincinnati Bengals (Knee, Questionable) – Updated 10/3
Joe Mixon is practicing in full and appears on track to return from a two-week absence and face the Dolphins this Sunday.
Giovani Bernard, Cincinnati Bengals (Thigh, OUT) – Updated 10/5
While Joe Mixon is expected to return this week, Gio Bernard is now out 2-4 weeks with the same injury (sprained MCL) that sidelined Mixon.
Joe Mixon, Cincinnati Bengals (Knee, Questionable) – Updated 10/3
Joe Mixon is practicing in full and appears on track to return from a two-week absence and face the Dolphins this Sunday. He’s in for a big workload with Bernard ruled out.
Adrian Peterson, Washington Redskins (Ankle, Questionable) – Updated 10/4
Adrian Peterson returned to practice Thursday and expects to be ready to face the Saints by next Monday night. This is a revenge spot for “AP.” He should ask for a heavy workload with Chris Thompson mixing in on passing downs.
Dalvin Cook, Minnesota Vikings (Hamstring, Questionable) – Updated 10/6
Dalvin Cook is expected to sit OUT this Sunday’s matchup against the Eagles, leaving Latavius Murray to potentially start with rookies Mike Boone and Roc Thomas mixing in for touches.
Alex Collins, Baltimore Ravens (Knee, Questionable) – Updated 10/5
Alex Collins was a limited participant on Wednesday and a DNP in practice Thursday. He practiced in full on Friday, but Javorius Allen could still see more work at Cleveland this Sunday.
Chris Carson, Seattle Seahawks (Hip, Questionable) – Updated 10/5
Chris Carson was a surprise inactive in Week 4 and started Week 5 by missing practice Wednesday. He got in a limited session on Thursday and is expected to play this Sunday, but his role is uncertain in a timeshare with Mike Davis.
Corey Clement, Philadelphia Eagles (Quad, Questionable) – Updated 10/5
Darren Sproles (hamstring) is out and Corey Clement seems unlikely to play this Sunday after missing practice throughout the week. Jay Ajayi will handle most of the work out of the backfield with Wendell Smallwood and Josh Adams mixing in.
Ezekiel Elliott, Dallas Cowboys (Ankle, Questionable)
Ezekiel Elliott is effectively the only weapon on the Cowboys offense right now, and his body is paying the price for the heavy workload. He’s likely to play in Week 5, but Rod Smith may start to see more work and is worth an add in deep fantasy leagues.
Lamar Miller, Houston Texans (Chest, Questionable) – Updated 10/5
In the words of Texans HC Bill O’Brien, Lamar Miller “is a bit banged up.” and he was limited Wednesday with a chest injury. He’s a game-time decision for a Sunday night tilt against the Cowboys. Alfred Blue should see more work regardless and D’Onta Foreman (Achilles) is expected to make his season debut.
Out for Extended Period: Le’Veon Bell, Rex Burkhead, Jerick McKinnon, Derrius Guice, Rob Kelley, Jeremy Hill
Will Fuller, Houston Texans (Hamstring, Questionable) – Updated 10/4
Will Fuller suffered a setback in Week 4 to his hamstring in Week 1 but is expected to play this Sunday. Keke Coutee should still have a role as a slot receiver and the rookie will be asked to step up if Fuller taps out with his hamstring issue.
Davante Adams, Green Bay Packers (Calf, Questionable) – Updated 10/6
Davante Adams suffered a calf injury this week but returned to practice Saturday. With Randall Cobb (hamstring) OUT and Geronimo Allison in the league’s concussion protocol, Aaron Rodgers could pepper Adams with targets if he’s active.
Randall Cobb, Green Bay Packers (Hamstring, Out) – Updated 10/5
Randall Cobb reportedly wasn’t close to playing in Week and will miss another contest this Sunday. The Packers are hopeful that Geronimo Allison (concussion) will be cleared to play and that Davante Adams will be able to go after practicing Saturday. Jimmy Graham and big-bodied South Florida product Marquez Valdes-Scantling are in line for increased targets.
Ted Ginn Jr., New Orleans Saints (Knee, OUT) – Updated 10/6
Ted Ginn Jr. will miss Monday night’s tilt against the Redskins. Rookie WR Tre’Quan Smith is expected to replace Ginn as the Saints situational deep threat, while Cameron Meredith and Ben Watson may see more targets underneath.
Marvin Jones Jr., Detroit Lions (Ankle, Questionable) – Updated 10/6
Marvin Jones Jr. popped up on the injury report Friday and is questionable to face the Packers this Sunday. Kenny Golladay would benefit most if Jones is out Sunday. Jones is expected to play.
John Ross, Cincinnati Bengals (Groin, Questionable) – Updated 10/4
John Ross didn’t practice Thursday and is questionable for Sunday’s matchup against the Dolphins. He’s fallen well behind A.J. Green and Tyler Boyd for targets, so his absence would have little impact.
DeVante Parker, Miami Dolphins (Quad, Questionable) – Updated 10/3
DeVante Parker practiced on a limited basis Wednesday. Jakeem Grant and Albert Wilson would continue to benefit if Parker can’t play this Sunday.
Sterling Shepard, New York Giants (Back, Questionable) – Updated 10/4
Sterling Shepard underwent surgery to remove a cyst from his back and missed practice Wednesday. He returned to practice Thursday and should be ready to play Sunday.
Sammy Watkins, Kansas City Chiefs (Hamstring, Questionable) – Updated 10/3
Sammy Watkins departed Monday night’s win with a hamstring pull and is questionable for a brutal Week 5 matchup at Jacksonville. Chris Conley and versatile TE Demetrius Harris would see more work if Watkins is out. Watkins practice on a limited basis and is a game-time decision.
Travis Benjamin, Los Angeles Chargers (Foot, OUT) – Updated 10/5
Travis Benjamin aggravated his foot injury in Week 4 and is expected to miss 2-3 weeks. Tyrell Williams and Mike Williams will both benefit from his absence.
Marquise Goodwin, San Francisco 49ers (Hamstring, Questionable) – Updated 10/5
Dante Pettis (knee) will not play this week and Marquise Goodwin is looking like a game-time decision to face the Cardinals.
Out for Extended Period: Marqise Lee, Mack Hollins, Mike Wallace, Pharoh Cooper, Curtis Samuel, Rishard Matthews, Bruce Ellington
O.J. Howard, Tampa Bay Bucs (Knee, Out)
O.J. Howard suffered a sprained MCL and will miss 2-4 weeks of action. The Bucs have a bye this week, but if Howard remains out in Week 6, Cameron Brate will see an increase in usage.
Tyler Eifert, Cincinnati Bengals (Ankle, Out)
The unlucky Tyler Eifert suffered another bad injury with a broken ankle on Sunday, ending his season. Tyler Kroft and C.J. Uzomah will form a committee at TE, and Tyler Boyd will continue to hog targets in the middle of the field. It’s yet another terrible break for Eifert.
Hayden Hurst, Baltimore Ravens (Foot, Questionable)
The Ravens’ promising rookie is expected to make his debut in Week 5 in a juicy matchup against the Browns. Give Hayden Hurst a look as a punt play in NFL DFS contests.
Will Dissly, Seattle Seahawks (Knee, Out) – Updated 10/3
Will Dissly departed Sunday’s game and is done for the season with a torn patella. He was off to a great start with Russell Wilson, who will now have to work with Nick Vannett as his primary TE.
Out for Extended Period: Greg Olsen, Delanie Walker, Hunter Henry, Jake Butt, Ed Dickson
Joe Staley, San Francisco 49ers (Knee, Questionable)
The 49ers could be without their starting LT in Week 5 against the Cardinals’ improving pass rush. Chandler Jones and Markus Golden could create problems on the outside if backup Shon Coleman is protecting the blind side.
Donald Penn, Oakland Raiders (Groin, Out) – Updated 10/3
Donald Penn left Sunday’s game with a groin injury and was replaced by solid rookie Brandon Parker. Penn has been placed on injured reserve.
Billy Price, Cincinnati Bengals (Foot, Out)
The Bengals’ rushing attack could struggle with Billy Price out. As we wrote, Joe Mixon (knee) may be able to return in Week 5.
Daniel Kilgore, Miami Dolphins (Triceps, Out) – Updated 10/2
The Dolphins lost their starting center for the season to a torn tricep. This is very bad news for Kenyan Drake, who ceded a ton of work to Frank Gore in a blowout loss last Sunday. Miami signed former Jet Wesley Johnson to play center.
Out for Extended Period: Isaiah Wynn, Travis Frederick, Cam Robinson, Jon Halapio, Andy Levitre, Matt Kalil, Daryl Williams, Seantrel Henderson, A.Q. Shipley
Antwaun Woods, Dallas Cowboys (Calf, Questionable)
Antwaun Woods entered Week 4 with a groin injury and wound up injuring his calf. Dallas will get David Irving back from a four-game suspension to bolster their defensive line in the event Woods can’t play this Sunday.
Cameron Wake, Miami Dolphins (Knee, Out) – Updated 10/6
Cameron Wake is by far the Dolphins best pass rusher, so his absence makes a big difference to a line that lost William Hayes (knee) for the year and could be without Andre Branch (knee). Andy Dalton and the Bengals offense should thrive at home.
Grady Jarrett, Atlanta Falcons (Ankle, Out) – Updated 10/3
Grady Jarrett left Sunday’s loss with an ankle injury and will not play Sunday at Pittsburgh. The Falcons injury-riddled defense is ripe for the picking.
Ziggy Ansah, Detroit Lions (Shoulder, Out) – Updated 10/5
Ziggy Ansah will remain absent for a Week 5 date with the Packers. Aaron Rodgers will have more time to throw with Ansah out.
Out for Extended Period: Joey Bosa, Everson Griffen, William Hayes, Muhammad Wilkerson, Timmy Jernigan, Ryan Glasnow, Vita Vea, Tyquan Lewis
Sean Lee, Dallas Cowboys (Hamstring, Questionable)
The Cowboys’ best defensive player is expected to miss 2-4 weeks with a hamstring issue. With a lack of capable TEs and receiving backs, Houston isn’t particularly well-equipped to take advantage of Lee’s absence, but it should open up the middle of the field for DeAndre Hopkins and Keke Coutee.
Dominique Easley, Los Angeles Rams (Knee, Out)
Dominique Easley, an OLB and pass rush specialist, underwent another knee surgery and is expected to miss the rest of the season. The Rams will hope that ILB Mark Barron (ankle) can make his season debut in Week 5.
Kyzir White, Los Angeles Chargers (Knee, Out) – Updated 10/2
Kyzer White underwent minor knee surgery and is expected to miss Sunday’s tilt against the Raiders. White is a great coverage LB and his absence further opens things up for TE Jared Cook.
Wesley Woodyard, Tennessee Titans (Shoulder, Questionable)
The Titans lost both Wesley Woodyard and starting safety Kenny Vaccaro (elbow) to injury last Sunday. Woodyard is expected to miss “some time” in the words of Titans HC Mike Vrabel.
K.J. Wright, Seattle Seahawks (Knee, Questionable)
K.J. Wright has yet to play this season, and the Seahawks will badly miss his coverage and tackling abilities if he’s out against Todd Gurley and the Rams this Sunday.
Mychal Kendricks, Seattle Seahawks (Suspension, Out) – Updated 10/2
Mychal Kendricks earned an indefinite suspension for his role in an insider trading scandal. The Seahawks back seven is very thin with Wright questionable and Earl Thomas done for the year.
Jarrad Davis, Detroit Lions (Knee, Questionable)
The Lions’ leader in tackles through three weeks is questionable with a knee injury.
Out for Extended Period: Jake Ryan, Deion Jones, Josh Martin
Aqib Talib, Los Angeles Rams (Ankle, Out)
Aqib Talib is expected to miss multiple weeks with a broken ankle. With Marcus Peters (calf) playing at less than full strength, the Rams’ secondary suddenly looked vulnerable in Week 4. Doug Baldwin and Tyler Lockett could surprise with their production this week.
Trumaine Johnson, New York Jets (Quad, Out) – Updated 10/5
Trumaine Johnson is out for a Week 5 home game against the Broncos. While Denver is struggling to pass effectively, this is a boost for Demaryius Thomas and Emmanuel Sanders.
Kenny Vaccaro, Tennessee Titans (Elbow, Out) – Updated 10/5
Kenny Vaccaro is expected to miss multiple weeks with a dislocated elbow. The Titans secondary will be more vulnerable in his absence, but the Bills offense isn’t necessarily equipped to capitalize.
Prince Amukamara, Chicago Bears (Shoulder, Questionable)
Prince Amukamara popped up on the injury report with a hamstring injury but actually missed a Week 4 tilt against the Bucs with a shoulder issue. The Bears defense still dominated against a previously red-hot offense. Prince now has a bye week to get healthy.
D.J. Hayden, Jacksonville Jaguars (Toe, Out)
D.J. Hayden will miss a second straight contest with a toe injury. The Jags will have a harder time stopping Tyreek Hill and the Chiefs’ elite offense with their slot CB out.
Earl Thomas, Seattle Seahawks (Leg, Out)
Earl Thomas broke his leg on Sunday, ending the ongoing drama of his reluctance to play for the Seahawks. Seattle’s secondary will become far more vulnerable with fourth-round pick Tedric Thompson playing free safety, and the Rams trio of talented receivers should feast this week.
Terrance Mitchell, Cleveland Browns (Arm, Out)
The Browns lost their No. 2 CB to a fractured arm. Terrance Mitchell was replaced by E.J. Gaines and T.J. Carrie, who had been playing well in the slot. Cleveland could struggle to contain John Brown and Michael Crabtree on the outside next week.
Trae Waynes, Minnesota Vikings (Concussion, Out) – Updated 10/5
The Vikings will be without No. 2 CB Trae Waynes in a matchup at the Eagles. With top CB Xavier Rhodes likely shadowing Alshon Jeffery, Nelson Agholor is primed to bounce back.
Eli Apple, New York Giants (Groin, Questionable) – Updated 10/5
Eli Apple got in a full practice Thursday and appears ready to return in Week 5. Devin Funchess and Torrey Smith may struggle in a tough matchup against Apple and Janoris Jenkins.
Jaquiski Tartt, San Francisco 49ers (Shoulder, Questionable)
The 49ers have been one of the most vulnerable teams to opposing passing attacks. Things will likely remain that way with Jaquiski Tartt and Richard Sherman (Achilles) questionable.
Bobby McCain, Miami Dolphins (Knee, Out)
Bobby McCain will be out 2-3 weeks with a knee injury. The Dolphins’ slot CB will be replaced by second-year UDFA Torry McTyer, which means Tyler Boyd could have another high-volume day for Cincy. Safety Rashad Jones (shoulder) is also expected to return after sitting in Week 4.
Micah Hyde, Buffalo Bills (Groin, Questionable)
Micah Hyde left Sunday’s loss with a groin injury and didn’t return. The Bills’ weak defense will be vulnerable down the field to Corey Davis and the Titans receivers.
Tramaine Brock, Denver Broncos (Thigh, Questionable)
The Broncos are not as strong at CB as in years past and have been exposed with rookie Isaac Yiadom replacing Brock. Adam Jones is also logging snaps, but is 35 years old at this point.
Out for Extended Period: Jason Verrett, Eric Berry, Patrick Robinson, Kevin Johnson, Vernon Hargreaves, Ross Cockrell, Phillip Gaines, Byron Maxwell, Daryl Worley, Ricardo Allen, Keanu Neal