The NFL is back in session with a big slate of games, with injury news creating implications in seasonal and daily fantasy football, as well as the sports betting market. Every week, we’ll bring you a list of the key injuries that could impact sports betting odds and DFS contests on sites such as DraftKings and FanDuel.
Note that players who fail to practice on Thursday and/or Friday leading into games may be listed as questionable but are in actuality closer to doubtful. Be sure to check back each afternoon to see if key players did any work in practice for clues as to their eventual status.
NFL coaches are famous for being taciturn when it comes to injuries, so nothing is set in stone when trying to predict how a player will perform, even if active.
This article will be updated several times throughout the week, so check back often. Here are the key injuries to watch ahead of Week 4:
Jimmy Garoppolo, San Francisco 49ers (Knee, Out)
The 49ers worst fears were realized when Jimmy Garoppolo suffered a torn ACL during Sunday’s loss at Kansas City. He’ll miss the rest of the season, and C.J. Beathard will fill in at QB, downgrading the Niners’ wide receivers dramatically but potentially maintaining value for George Kittle as a safe outlet over the middle.
Aaron Rodgers, Green Bay Packers (Hamstring, Questionable)
Aaron Rodgers suffered a strained hamstring on top of a knee sprain, further limiting his mobility. He plans to keep gutting through it and will see most of his snaps out of shotgun formations against the Bills.
Tyrod Taylor, Cleveland Browns (Concussion, Questionable)
Even if Tyrod Taylor is active, he will back up No. 1 overall pick Baker Mayfield. Mayfield is coming off an impressive debut and will raise the stock of all Browns receivers, particularly Jarvis Landry, who should eat against the weak Raiders secondary this Sunday.
Marcus Mariota, Tennessee Titans (Elbow, Questionable)
Marcus Mariota played through an elbow injury but was extremely ineffective against the Jaguars’ elite secondary last Sunday. He is expected to suit up this week, but is not worth considering in another brutal matchup against the Eagles this Sunday.
Leonard Fournette, Jacksonville Jaguars (Hamstring, Questionable) -Updated 9/28
Leonard Fournette returned to practice but coach Doug Marrone says he’s 50/50 to play on Sunday. The Jets defense has been vulnerable to the rush so far this season.
Devonta Freeman, Atlanta Falcons (Knee, Out) – Updated 9/28
Devonta Freeman returned to practice on a limited basis Thursday, but has been ruled out of a Week 4 matchup against the Bengals. With Ito Smith (ribs) also questionable, Tevin Coleman is poised for another heavy workload.
LeSean McCoy, Buffalo Bills (Ribs, Questionable) – Updated 9/28
LeSean McCoy vowed to return in a Week 4 matchup at Green Bay, but also admitted he suffered a setback during practice. He’s a risky option with tender rib cartilage.
Matt Breida, San Francisco 49ers (Knee, Questionable) – Updated 9/29
Matt Breida returned to practice Thursday but called himself a game-time decision. “I’ve got to feel comfortable. It’s a long season.” He could be very busy in the passing game should he be able to go with C.J. Beathard under center. Meanwhile, Alfred Morris (knee) is now questionable.
Jay Ajayi, Philadelphia Eagles (Back, Questionable) – Updated 9/28
Jay Ajayi is expected to play this week, but Darren Sproles (hamstring) has been ruled out. Ajayi is hard to trust in a tough matchup against the Titans with Corey Clement and Wendell Smallwood threatening to steal touches.
Rex Burkhead, New England Patriots (Neck, Out) – Updated 9/26
The Patriots sent Rex Burkhead to injured reserve with a neck injury and signed Kenjon Barner off the practice squad. James White will have a stranglehold on passing downs with Sony Michel handling most carries on early downs.
Out for Extended Period: Le’Veon Bell, Joe Mixon, Mark Ingram, Jerick McKinnon, Derrius Guice, Rob Kelley, Jeremy Hill
A.J. Green, Cincinnati Bengals (Groin, Questionable) – Updated 9/28
The Bengals top receiver left Sunday’s loss in the third quarter due to a groin injury, but practiced in full on Friday and is expected to play Sunday.
Keenan Allen, Los Angeles Chargers (Knee, Questionable) – Updated 9/29
Keenan Allen missed practice on Wednesday and Thursday before getting in a limited session Friday. He’s officially questionable for Sunday’s plum draw against the 49ers, so Mike Williams and Tyrell Williams could be very busy with Travis Benjamin (foot) also questionable. Allen is expected to play.
Golden Tate, Detroit Lions (Hip, Questionable) – Updated 9/29
Golden Tate was a late addition to the injury report. He will likely play but if he’s ruled out, Kenny Golladay and Marvin Jones Jr. will benefit. T.J. Jones would see snaps as a slot receiver as well.
Alshon Jeffery, Philadelphia Eagles (Shoulder, Questionable) – Updated 9/28
Alshon Jeffery has been cleared for contact and could suit up against the Titans this Sunday. Yet he’s also dealing with an illness that kept him out of practice Thursday and Tennessee has been great on defense this year.
Doug Baldwin, Seattle Seahawks (Knee, Questionable) – Updated 9/28
Doug Baldwin got in a full practice on Friday and will return to action this Sunday according to coach Pete Carroll. He should move around the formation enough to avoid shadow coverage from Patrick Peterson.
Josh Gordon, New England Patriots (Hamstring, Questionable) – Updated 9/28
The Patriots likely kept Josh Gordon inactive last Sunday night because he didn’t know the full playbook yet. However, after the horrific showing by their receivers in Detroit, they’ll likely turn their new acquisition loose in a divisional tilt against Miami. Gordon has been limited in practice through Thursday. Most beat writers expect him to suit up.
Randall Cobb, Green Bay Packers (Hamstring, Questionable) – Updated 9/29
After a rough Week 3, Randall Cobb is officially questionable to suit up against the Bills. Jimmy Graham could see more looks over the middle of the field if Cobb is hobbled, which may be the case considering Cobb couldn’t practice Saturday.
DeVante Parker, Miami Dolphins (Quad, Questionable) – Updated 9/29
After playing on 75 percent of offensive snaps in Week 3, Parker pops up with a quad issue. If he sits, Jakeem Grant would benefit most.
Rishard Matthews, Tennessee Titans (Personal, Out) – Updated 9/26
Frustrated by a lack of playing time, Rishard Matthews has walked out on the Titans. He may resurface with another team, while Taywan Taylor will benefit as more of a boom-bust No. 2 receiver for Tennessee.
Bruce Ellington, Houston Texans (Hamstring, Out)
Bruce Ellington was already losing his consistent role with Will Fuller back, but now he’s on I.R. with a hamstring injury.
**Golden Tate was a late addition to the injury report and is officially questionable to suit up on Sunday.
Out for Extended Period: Julian Edelman, Travis Benjamin, Marqise Lee, Mack Hollins, Mike Wallace, Pharoh Cooper, Curtis Samuel
Jack Doyle, Indianapolis Colts (Hip, Out) – Updated 9/28
With Jack Doyle out, Eric Ebron saw a team-high 11 targets despite a brutal matchup against the Eagles. Ebron (shoulder) is reportedly good to go this Sunday against a winless Texans team that’s been gashed by TEs this season.
Evan Engram, New York Giants (Knee, Out) – Updated 9/26
After getting hit low, Evan Engram left Sunday’s win over the Texans. He’s out 2 -4 weeks with a sprained MCL. Rhett Ellison saw more work with Engram out and caught a short TD pass but is not a great fantasy option going forward. Odell Beckham Jr. and Sterling Shepard will see a higher target share, beginning with a juicy matchup against the Saints this Sunday.
Hayden Hurst, Baltimore Ravens (Foot, Questionable) – Updated 9/28
The Ravens rookie is practicing on a limited basis this week. Hurst was a first-round pick with loads of athleticism, so he’ll be a guy to keep an eye on as he could help a pretty good offense from a betting and DFS perspective. Even if he plays, it’s likely he will be on a snap count.
Jake Butt, Denver Broncos (Knee, Out) – Updated 9/27
Jake Butt suffered a non-contact injury during Thursday’s practice and the Broncos fear that he tore his ACL. Jeff Heuerman would see more snaps if Butt is indeed done for the year.
Out for Extended Period: Greg Olsen, Delanie Walker, Hunter Henry, Ed Dickson
David DeCastro, Pittsburgh Steelers (Hand, Questionable)
The Steelers pulled off a bounce-back win without David DeCastro on Monday in Tampa. Their rushing attack, which now seems destined to run through James Conner, would only get more potent if the Pro-Bowler returns in Week 4.
Billy Price, Cincinnati Bengals (Foot, Out) – Updated 9/28
The Bengals rushing attack could struggle with Billy Price out. Gio Bernard is expected to handle a heavy workload with Joe Mixon (knee) on the shelf, but he may do more work as a receiver.
Trai Turner, Carolina Panthers (Concussion, Questionable)
Trai Turner was inactive in Week 3. The Panthers will also be without both starting tackles — Matt Kalil and Daryl Williams — for the rest of the season. Carolina should continue with a quick-hitting approach in the passing game to the benefit of Christian McCaffrey.
Joe Haeg, Indianapolis Colts (Ankle, Out) – Updated 9/28
The Colts are also missing LT Anthony Castonzo (hamstring). Haeg’s absence would make J.J. Watt even more likely to terrorize Andrew Luck.
Morgan Moses, Washington Redskins (Concussion, Questionable)
The Redskins lost starting RT Morgan Moses to a concussion, but Washington has a bye in Week 4 and should have the big man back by Week 5.
Out for Extended Period: Isaiah Wynn, Jack Conklin, Travis Frederick, Anthony Castonzo, Cam Robinson, Jon Halapio, Andy Levitre, Matt Kalil, Daryl Williams, Seantrel Henderson, A.Q. Shipley
Trey Flowers, New England Patriots (Concussion, Questionable)
Trey Flowers was unable to play in Week 3, and the Patriots will hope he clears the concussion protocol in order to jolt their dormant pass rush in Week 4.
Calais Campbell, Jacksonville Jaguars (Ankle, Questionable)
After recording two sacks, Calais Campbell was forced from Sunday’s divisional slugfest with an ankle issue. Jacksonville would be even more dominant against the Jets next week if Campbell is cleared to play.
Ziggy Ansah, Detroit Lions (Shoulder, Out) – Updated 9/28
Ziggy Ansah will miss a Week 4 date at Dallas, which is good news for Dak Prescott. The Cowboys offense has been anemic, but perhaps Ezekiel Elliott can get going with Ansah out.
Everson Griffin, Minnesota Vikings (Personal, Out)
Everson Griffin is dealing with mental health issues and will be inactive on Thursday night against the Rams. Jared Goff and the Rams offense will benefit.
Muhammad Wilkerson, Green Bay Packers (Ankle, Out)
The Packers were gashed on the ground by Adrian Peterson and the Redskins last Sunday and reports say they have lost Muhammad Wilkerson for the season with a broken ankle. Green Bay is suddenly vulnerable on the ground, and the Bills appear capable of exploiting that weakness with either Chris Ivory or LeSean McCoy.
Andre Branch, Miami Dolphins (Knee, Questionable)
Andre Branch suffered an MCL sprain, and fellow DE William Hayes tore his ACL trying to avoid a roughing the passer penalty last Sunday. If Branch is out for Sunday’s tilt against the Patriots, Tom Brady will have a better chance to bounce back.
Ryan Glasnow, Cincinnati Bengals (Knee, Out) – Updated 9/28
The Bengals lost one of their best run-stopping linemen for the season, as Ryan Glasnow suffered a torn ACL. That could open things up for Tevin Coleman and the Falcons running game.
Denico Autry, Indianapolis Colts (Ankle, Questionable)
Denico Autry returned to practice in full on Friday and looks likely to suit up against Houston.
Out for Extended Period: Joey Bosa, Corey Liuget, Timmy Jernigan, Vita Vea, Tyquan Lewis
Sean Lee, Dallas Cowboys (Hamstring, Questionable)
The Cowboys best defensive player is expected to miss 2-4 weeks with a hamstring issue. Detroit TE Luke Willson and pass-catching back Theo Riddick should benefit most in Week 4.
C.J. Mosley, Baltimore Ravens (Knee, Questionable)
The Ravens rising star is expected to suit up on Sunday night. That hurts James Conner and the Steelers running game, as well as TEs Vance McDonald and Jesse James.
Nick Perry, Green Bay Packers (Concussion, Questionable)
Nick Perry is questionable to suit up this Sunday and the Packers run defense could struggle once again if he’s out.
Dee Ford, Kansas City Chiefs (Groin, Questionable)
The Chiefs lost a good pass rusher in Dee Ford and will likely get into more shootouts going forward if he can’t return in time for Monday night’s tilt at Denver.
K.J. Wright, Seattle Seahawks (Knee, OUT) – Updated 9/28
Bobby Wagner (groin) returned and helped the Seahawks defense hold serve against the Cowboys in Week 3. He’ll need to step up again against David Johnson and the Cardinals as Wright has been ruled out.
Out for Extended Period: Ryan Shazier, Jake Ryan, Vontaze Burfict, Thomas Davis, Deion Jones
Aqib Talib, Los Angeles Rams (Ankle, Out)
Aqib Talib is expected to miss multiple weeks with a broken ankle, putting the Rams in a bad position with the Vikings elite WR duo (Stefon Diggs and Adam Thielen) coming to town Thursday.
Prince Amukumara, Chicago Bears (Hamstring, Questionable) – Updated 9/28
Prince Amukumara popped up on the injury report with a hamstring injury and was limited in practice Thursday. He’s questionable to face Mike Evans and the Bucs on Sunday.
D.J. Hayden, Jacksonville Jaguars (Toe, Out) – Updated 9/28
The Jaguars will be without their starting slot CB in Sunday’s home matchup against the Jets, boosting the prospects of Quincy Enunwa.
Richard Sherman, San Francisco 49ers (Heel, Questionable)
Richard Sherman left Sunday’s loss in a walking boot and is questionable for Week 4. With the Niners season taking a serious downturn, he should play it safe.
Earl Thomas, Seattle Seahawks (Personal, Questionable) – Updated 9/26
Earl Thomas is questionable to play this week due to a personal issue. This is something to monitor as the week progresses, but he was out there and made a big difference in Week 3.
Eli Apple, New York Giants (Groin, Questionable)
With Eli Apple out, B.W. Webb filled in and did well enough for the Giants to win in Week 3. Yet Webb is a serious downgrade, and he may struggle to stop Saints speedster Ted Ginn Jr. this week.
Ricardo Allen, Atlanta Falcons (Achilles, Out) – Updated 9/26
After losing starting safety Keanu Neal and LB Deion Jones for the season, the Falcons took another huge hit with Ricardo Allen going down for the season. Andy Dalton and the Bengals will likely get into a shootout at the Georgia Dome.
Patrick Robinson, New Orleans Saints (Ankle, Out)
The Saints have been absolutely shredded through the air this year and have lost a capable slot CB in Patrick Robinson to a broken ankle. Odell Beckham Jr. and Sterling Shepard will benefit if Robinson is inactive this Sunday.
Tramaine Brock, Denver Broncos (Groin, Questionable)
The Broncos are not as strong at CB as in years past and were exposed with rookie Isaac Yiadom replacing Brock last Sunday. The Chiefs’ elite passing attack could be all over Yiadom if he’s forced to start this week.
Davon House, Green Bay Packers (Shoulder, Out)
The Packers placed Davon House on I.R. and signed a capable veteran in Bashaun Breeland, who represents an upgrade at the position.
Patrick Chung, New England Patriots (Concussion, Questionable)
Patrick Chung should return from a concussion this week. If he’s out, Kenny Stills would have a better chance of breaking a big play against the struggling Patriots.
Out for Extended Period: Jason Verrett, Eric Berry, Kevin Johnson, Jimmy Smith, Vernon Hargreaves, Ross Cockrell, Phillip Gaines, Byron Maxwell, Daryl Worley, Daniel Sorensen, Keanu Neal