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The NFL is back in session with 16 games on the Week 2 slate, creating implications in seasonal and fantasy football, as well as the sports betting market.

Every week, we’ll bring you a list of the key injuries that could impact betting lines and fantasy contests on sites such as DraftKings and FanDuel.

Note that players who fail to practice on Thursday and/or Friday leading into games may be listed as questionable but are in actuality closer to doubtful. Be sure to check back each afternoon to see if key players did any work in practice for clues as to their eventual status.

NFL coaches are famous for being taciturn when it comes to injuries, so nothing is set in stone when trying to predict how a player will perform, even if active.

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Here are the key injuries to watch ahead of Week 2:

Quarterback 

Carson Wentz, Philadelphia Eagles (Knee, Questionable) 

Wentz still hasn’t been cleared for contact and will not return in Week 2. Nick Foles struggled badly in his first start of the season. Defenses could be keying in on his weaknesses after his miraculous run last postseason. Don’t sleep on the Bucs (+3) against the defending champs at home.

Aaron Rodgers, Green Bay Packers (Knee, Questionable) – Update 9/14

While he was able to finish Sunday night’s comeback over the Bears, Aaron Rodgers is questionable ahead of a brutal matchup against the Vikings this week. There is no bigger gap between a starter and backup than between Rodgers and DeShone Kizer, who would give the Pack essentially no chance to win if starting. Rodgers has not been able to practice, but chances are he’ll be out there on the same painkillers that allowed him to finish last week’s game against the Bears.

Marcus Mariota, Tennessee Titans (Elbow, Questionable) – Update 9/14

New Titans HC Luke Vrabel claims that both Marcus Mariota and backup Blaine Gabbert will both play in Sunday’s home game against the Texans. Perhaps that’s coach speak, but it’s an indication that Mariota’s dreadful Week 1 performance could be injury related. Either way, the Texans defense is poised to bounce back in a big way against either limited passer.

Jameis Winston, Tampa Bay Buccaneers (Suspension, Out)

Winston is suspended for the first three games of the season. Ryan Fitzpatrick absolutely flamed the Saints defense for 417 yards and four TD in his season debut and could play his way into a quarterback controversy if he performs well against the Eagles this Sunday.

Running Back

Leonard Fournette, Jacksonville Jaguars (Hamstring, Questionable) – Update 9/14

Jaguars HC Doug Marrone said he’s optimistic that Leonard Fournette will be able to suit up for a huge Week 2 tilt against the Patriots. The man-child pulled his hamstring and has not been able to practice this week. Yet Marrone said Fournette could still play if he doesn’t practice, indicating he’ll likely be out there in a limited capacity while sharing time with T.J. Yeldon. The Jaguars promoted Brandon Wilds from the practice squad, indicating that he might be needed to back up Yeldon.

Le’Veon Bell, Pittsburgh Steelers (Personal, Out) 

With Bell continuing his holdout, James Conner cleaned up with 192 YFS in the Steelers’ opener at the Browns. Conner will start with another juicy draw against the Chiefs. The Steelers’ (-5.5) betting line has moved towards Pittsburgh, but they can still cover against the Chiefs by going pass-heavy at home.

Marlon Mack, Indianapolis Colts (Hamstring, Questionable) – Update 9/14

With Marlon Mack out in Week 1, Jordan Wilkins led the Colts’ RB committee with Nyheim Hines behind him. Neither back is talented enough to produce behind one of the worst offensive lines in football. Mack got in a full practice on Friday and should be out there against Washington. The Redskins (-5.5) line has increased despite the potential presence of Indy’s lead back.

Devonta Freeman, Atlanta Falcons (Knee, Out) – Update 9/14

Devonta Freeman left last Thursday’s loss to the Eagles, and is out this week. Tevin Coleman will see the bulk of the carries for Atlanta and carries a cheap price tag in DFS.

Rex Burkhead, New England Patriots (Concussion, Questionable) – Update 9/14

Now Rex Burkhead is questionable with a concussion, further reducing the amount of receiving weapons available to the Patriots. James White would become a much more secure play if Burkhead can’t go, and with Sony Michel (knee) also questionable, White is a Cash game viable option.

Jeremy Hill, New England Patriots (Knee, Out) 

Jeremy Hill left the Patriots opener with a torn ACL and will miss the rest of the season. James White remains the best bets for action out of the backfield in a pass-heavy New England attack that is becoming increasingly low on weapons.

Darren Sproles, Philadelphia Eagles (Hamstring, Out) – Update 9/14

Darren Sproles has been ruled out for Week 2, opening up more touches for Corey Clement in the passing game. Jay Ajayi is locked into heavy usage as the Eagles primary rusher.

LeGarrette Blount, Detroit Lions (Knee, Questionable) 

The Lions pathetic rushing attack did nothing to open up running lanes for big old LeGarrette Blount. He also suffered a mild knee injury and will likely lose work to rookie Kerryon Johnson going forward, although Johnson struggled to gain any ground as well.

Mark Ingram, New Orleans Saints (Suspension, Out) 

With Ingram suspended in Week 1, Alvin Kamara logged 52 of 64 offensive snaps. He should continue to dominate in a juicy Week 2 matchup against Cleveland.

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Wide Receiver

Doug Baldwin, Seattle Seahawks (Knee, Out)  – Update 9/14
Doug Baldwin tried to give it a go in Week 1 but tapped out early in a tough matchup against Denver. He’s reportedly dealing with a partially torn MCL in his left knee, which is different from the right knee issue that bothered him throughout the preseason. Either way the injury should keep him out 2-4 weeks at the very least. Brandon Marshall showed he still has something in the tank with 46 receiving yards and a TD in Denver, but Tyler Lockett should be the biggest beneficiary as Russell Wilson looks for a new go-to-guy.
DeSean Jackson, Tampa Bay Bucs (Concussion, Questionable) – Update 9/14

Ryan Fitzpatrick found the old burner five times for 148 yards and two scores in a Week 1 eruption, but DeSean Jackson suffered an apparent concussion in New Orleans. If he misses a Week 2 showdown with the Eagles, Chris Godwin would become a much more secure option as the No. 2 receiver for an apparently red-hot quarterback. But Jackson seems likely to tough it out.

Alshon Jeffery, Philadelphia Eagles (Shoulder, Out) – Update 9/14

Jeffery will miss at least one more game. Nelson Agholor should continue to benefit after seeing 10 targets in the season opener. Zach Ertz also saw 10 targets, and he’s a great bounce-back candidate against a Bucs defense that’s vulnerable down the seams. Also consider rookie TE Dallas Goedert as a potential DFS punt play.

DeVante Parker, Miami Dolphins (Finger, Doubtful) – Update 9/14

With DeVante Parker out in Week 1, Kenny Stills went for 104 yards and 2 TDs on a rain-soaked field. Jakeem Grant saw seven targets with Parker out, but Parker is expected to return in Week 2. This clouds the security of any Dolphins receivers, but Stills remains the preferred play.

Will Fuller, Houston Texans (Hamstring, Questionable) 

With Will Fuller out in Week 1, Bruce Ellington made the most of his opportunities and caught the lone TD pass from DeShaun Watson. The Texans offense would become much more dynamic if Fuller can suit up in a juicy matchup against the Titans this Sunday. Bet on Watson regaining his rhythm if the line is close in favor of Houston.

Marquise Goodwin, San Francisco 49ers (Thigh, Out) – Update 9/14

The downfield burner bruised his thigh in a tough matchup at Minnesota and is out for Week 2 against the Lions. Tight end George Kittle should see a boost in targets. While Pierre Garcon is also slated for a bigger workload, he could struggle against Lions CB Darius Slay. Dante Pettis is now squarely in play as a longshot GPP option since he should fill Goodwin’s role as a downfield threat.

Josh Gordon, Cleveland Browns (Hamstring, Out) – Update 9/14

In a surprise move, Josh Gordon has been ruled out for the Browns with a hamstring injury. The Browns are big road dogs the New Orleans. Jarvis Landry has a good shot to see double-digit targets in a comeback effort and Rashard Higgins should see more snaps on the outside.

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Tight End

Delanie Walker, Tennessee Titans (Ankle, Out) 

Delanie Walker was carted off with a bad-looking ankle injury during the fourth quarter of Sunday’s elongated loss at Miami. He has been ruled out for the season, opening the door for second-year man Jonnu Smith to start. Corey Davis and Rishard Matthews will see an upswing in targets, but the weak Titans offense is now much less capable of sustaining drives. Tennessee could also be without two starting offensive linemen next week, with Taylor Lewan and Jack Conklin questionable.

Greg Olsen, Carolina Panthers (Foot, Out) 

Greg Olsen came into Week 1 nursing a back injury but suffered an unrelated foot injury that forced him to leave the stadium in a walking boot. He has a fractured foot and could miss the rest of the season. The Panthers will look to replace him with Ian Thomas, while Devin Funchess should theoretically see more looks in the red zone after his Week 1 dud and Christian McCaffrey sees a ton of volume.

Offensive Line

Travis Frederick, Dallas Cowboys (Illness, Questionable) 

The Cowboys were way out of sorts with Joe Looney starting at center in Week 1, leading to a dud from Ezekiel Elliott and the entire offense. There is no timetable for Frederick’s return, which makes the Cowboys a team to consider betting against as the host the Giants on Sunday night.

Seantrel Henderson, Houston Texans (Ankle, Out) 

The Texans lost Seantrel Henderson, their starting right tackle, for the season to a broken ankle. Lamar Miller is trending down, along with the rest of Houston’s running game. But we should see more scrambling and playmaking from DeShaun Watson once he knocks the rust off.

David DeCastro, Pittsburgh Steelers (Hand, Questionable) 

The Steelers pro-bowl guard is expected to play through a fractured hand, but his effectiveness could diminish in a Week 2 home tilt against the Chiefs.

Josh Sitton, Miami Dolphins (Shoulder, Out) 

The Dolphins sent LG Josh Sitton to injured reserve and that could hurt the prospects of Kenyan Drake, who is struggling to see a bigger workload behind Frank Gore.

Jack Conklin, Tennessee Titans (Knee, Out) – Update 9/14

Conklin is expected to miss the first few games while rehabbing his surgically repaired knee. Now, two-time Pro Bowl offensive tackle Taylor Lewan (concussion) is also out and the Titans have signed OT Tyler Marz off the street to try and stop J.J. Watt and company. This sets up as a bounce-back spot for Houston (NL), who should be underdogs on the road once the line is set.

Anthony Castonzo, Indianapolis Colts (Hamstring, Questionable) 

The Colts have one of the worst offensive lines in football and looked dreadful without starting offensive tackle Anthony Castonzo. If he can’t play in Week 2, Washington (-3.5) would become an even better bet. The Colts placed starting RT J’Marcus Webb on injured reserved with a hamstring injury, leaving Andrew Luck extremely vulnerable to opposing pass rushes.

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Defensive Line

Joey Bosa, Los Angeles Chargers (Foot, Out) 

Bosa could miss a second consecutive game, and the Chargers should be cautious in a winnable game at Buffalo this Sunday. Defensive tackle Corey Liuget (suspension) is also expected to remain out, giving LeSean McCoy a chance to bounce back in what could be the first start for rookie QB Josh Allen. Bosa’s continued absence would make the Chargers (-7.5) a tough sell on an East Coast trip, even against the lowly Bills.

Emmanuel Ogbah, Cleveland Browns (Ankle, Out) 

The Browns awful run defense could get even worse with left defensive end Emmanuel Ogbah out. This raises the ceiling further of the potential RB1 in Week 2, Alvin Kamara.

Ezekiel Ansah, Detroit Lions (Shoulder, Questionable) 

The Lions may be without one of the premier pass rushers in the NFL this Sunday on the road against the burgeoning 49ers offense. Jimmy Garoppolo would become a buy-low candidate in DFS contests, and the Niners (-3.5) would be worth consideration in a bounce-back spot at home.

Linebacker

Olivier Vernon, New York Giants (Ankle, Questionable) 

While Olivier Vernon missed a Week 1 matchup at the Jaguars with a high-ankle sprain, the Giants defense still held its own. The G-Men should be able to limit Dak Prescott in a divisional matchup this Sunday. They are worth taking on the money line.

K.J. Wright, Seattle Seahawks (Knee, Doubtful) 

With Shaquem Griffin starting instead of K.J. Wright, the deteriorating Seahawks defense looked even more vulnerable. Seattle is no longer a unit to fear. The improved Bears (-3) could handle the Seahawks at home on Monday night.

Deion Jones, Atlanta Falcons (Foot, Out) 

With safety Keanu Neal done for the season, the Falcons are becoming extremely thin in the middle of the field. Jones was a difference maker and his production will not be easily replaced by third-round pick Duke Riley. Luckily for Atlanta, the Panthers will be without Greg Olsen and might struggle to exploit Riley in coverage.

Thomas Davis, Carolina Panthers (Suspension, Out) 

Even with Thomas Davis out, the Panthers shut down the Cowboys’ vaunted running game. Yet the Panthers could feel his absence against the Falcons’ double-headed monster of Devonta Freeman and Tevin Coleman under the Georgia Dome.

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Defensive Backs

Joe Haden, Pittsburgh Steelers (Hamstring, Out) – Update 9/14

Joe Haden suffered a Grade 1 hamstring in Week 1 and will miss Sunday’s game. With their top CB hobbled, the Steelers will be hard pressed to contain Chiefs all-purpose weapon Tyreek Hill. Stacking Hill with Antonio Brown looks like a great strategy in DFS tournaments given the state of both secondaries. Pittsburgh RCB Artie Burns (toe) is also questionable.

Kevin Johnson, Houston Texans (Concussion, Out) 

The Texans lost LCB Kevin Johnson for the year with a bad concussion, leaving them more vulnerable on the outside. That could help Titans top WR Corey Davis have a big day despite the shaky situation of Tennessee’s quarterbacks.

Brent Grimes, Tampa Bay Bucs (Groin, Questionable) 

The Bucs missed Grimes in Week 1, as Michael Thomas set a franchise record with 16 receptions for 180 yards. Now second CB Vernon Hargreaves (shoulder) is done for the year, so Tampa might sign former Redskins CB Bashaun Breeland. If Grimes can’t go and Breeland isn’t in the fold, Philadelphia’s Nelson Agholor could have a big day along with Zach Ertz.

Trae Waynes, Minnesota Vikings (Knee, Questionable) 

The Vikings are so deep at cornerback that Trae Waynes’ absence was hardly noticed last Sunday. Rookie Mike Hughes moved outside and recorded a pick six while Jayron Kearse played well at nickel against the 49ers. The Vikings defense is one of the best in the NFL. They should even contain Aaron Rodgers at Lambeau next week.

Eric Berry, Kansas City Chiefs (Heel, Doubtful) 

The Chiefs pass defense was rather dreadful with Berry and free safety Daniel Sorensen (shin) unavailable in Week 1. Antonio Brown and company should absolutely shred that unit if the weather is good in Pittsburgh this Sunday.

Casey Hayward, Los Angeles Chargers (Hamstring) 

While Hayward isn’t expected to miss any time, his nagging hamstring injury clearly affected his performance in Week 1. That downturn contributed to a monstrous outing from Tyreek Hill. With Jason Verrett (Achilles) out for the season, the Chargers secondary may be one to target. Fortunately for San Diego, they face arguably the worst team in the NFL in Buffalo this Sunday.

Keanu Neal, Atlanta Falcons (Knee, Out) 

The Falcons lost starting safety Keanu Neal for the season with a torn ACL. Damontae Kazee should take over for a team with a mediocre pass defense.

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