The San Francisco 49ers (2-3) carry a three-game losing run into a Week 7 battle with the Indianapolis Colts (2-4). The Colts ( on the moneyline to win) hit the road on October 24, 2021 at 8:20 PM ET on NBC against the 49ers ( ). The over/under for the contest is set at points.
The betting insights and predictions in this article reflect betting data from DraftKings as of October 24, 2021, 7:48 PM ET. See the table below for current betting odds and CLICK HERE to bet at DraftKings Sportsbook.
49ers Vs Colts Odds
|ATS pick||Over/Under pick|
|Colts (+4.5)||Over (44)|
Predictions are calculated by a data-driven algorithm (raw power score) that ranks head-to-head matchup results within a closed network of games. Prediction confidence is determined by the delta between each team’s raw power score.
Team Stat Rankings
|Off. Points per Game (Rank)||23.4 (23)||23.2 (18)|
|Def. Points per Game (Rank)||23.8 (5)||21.8 (13)|
|Off. Yards per Play (Rank)||5.8 (15)||5.9 (9)|
|Def. Yards per Play (Rank)||5.3 (8)||5.9 (21)|
|Turnovers Allowed (Rank)||7 (14)||5 (3)|
|Turnovers Forced (Rank)||2 (31)||12 (4)|
49ers Betting Insights
- San Francisco has one win against the spread this year.
- The 49ers are winless ATS (0-1) when playing as at least 4.5-point favorites this year.
- Two of San Francisco’s five games have gone over the point total.
- In three games this year, San Francisco and its opponent have combined to score more than 44 points.
- The total for this game is 44, 5.4 points fewer than the average total in 49ers games thus far this season.
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Colts Betting Insights
- Indianapolis has beaten the spread four times in six games.
- The Colts have one win ATS (1-1) as a 4.5-point favorite or more this year.
- There have been three Indianapolis games (out of six) that hit the over this year.
- Indianapolis’ games have finished with over 44 points scored four times this year.
- This season, Colts games have resulted in an average scoring total of 46.3, which is 2.3 points higher than the over/under for this matchup.
49ers Players to Watch
- Jimmy Garoppolo has 925 pass yards for San Francisco, completing 66.1% of his passes and tossing five touchdowns and two interceptions this season.
- The team’s top rusher, Elijah Mitchell, has carried the ball 45 times for 189 yards (37.8 per game), scoring one time.
- Trey Sermon has carried the ball 31 times for 135 yards (27.0 per game) and one touchdown.
- Deebo Samuel has hauled in 31 catches for 548 yards (109.6 yards per game) to lead the team so far this season. He’s found the end zone three times as a receiver.
- Kyle Juszczyk has reeled in 14 passes while averaging 27.0 yards per game and scoring one touchdown.
- Mohamed Sanu has a total of 97 receiving yards so far this year, grabbing 10 passes.
- Nick Bosa paces the team with 5.0 sacks, and also has 8.0 TFL and 19 tackles.
- So far Fred Warner leads the team in both tackles and interceptions. He has totaled 45 tackles and 2.0 TFL this season.
Colts Players to Watch
- Carson Wentz has put up 1,545 passing yards, or 257.5 per game, so far this season. He has completed 64.2% of his passes and has collected nine touchdowns with one interception. He’s also contributed on the ground with 12.3 rushing yards per game.
- Jonathan Taylor’s team-high 472 rushing yards have come on 87 carries, with four touchdowns. He also leads the team with 210 receiving yards (35.0 per game) on 15 catches with one touchdown.
- Nyheim Hines has rushed for 101 yards on 26 carries with one touchdown, while also catching 15 passes for 133 yards.
- Michael Pittman Jr. paces his squad with 403 receiving yards on 31 catches with one touchdown.
- Zach Pascal’s 29 targets have resulted in 18 receptions for 204 yards and three touchdowns.
- Al-Quadin Muhammad has 2.0 sacks to pace the team, and also has 3.0 TFL and 24 tackles.
- Bobby Okereke is the team’s leading tackler this year. He’s collected 51 tackles, 1.0 TFL, and 1.0 sack.
- Darius Leonard has picked off a team-high two passes. He also has 45 tackles, 2.0 TFL, and four passes defended to his name.
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