Week 6 NFL Parlay Picks And Predictions

Posted By Brian Sausa on October 14, 2021

At online sportsbooks across the United States, sports fans betting on the National Football League have a wide array of options to choose from for each and every game on the schedule. That said, certain betting markets are more popular than others, and among the fan favorites during NFL season are parlays.
These days, there are several different types of parlays offered at betting sites. Below, we’ll explain some of the different choices and make our Week 6 NFL parlay picks.


Parlays combine two or more selections into the same wager in exchange for overall ods that are longer than a typical straight bet. The potential to win much more than you risk is one of the reasons why parlays are so popular.

The exact odds of a parlay depend on the number of selections each of the corresponding odds, but all parlays will boost your potential payout in some way. But keep in mind that all legs of your parlay need to win for you to receive the full payout. A push will remove the selection and keep the parlay alive.

These bets can include moneylines, spreads, totals, and even props in many cases, and bettors can choose to link together just two sides, or up 10, 12, or 15 depending on the sportsbook. Parlays are wholly customizable, meaning bettors get to choose how big they want the odds to go, how many sides will be included, and how difficult to make each leg of the parlay.

There are several ways to bet parlays. Some bettors just want the highest odds and largest payout possible, and a parlay is one way to get there. But just because the occasional big wins are what you see go viral on social media, they are closer to the exception and not the rule.

The way to establish even a modicum of consistency is to have just two or three sides and avoid chasing the astronomical odds. Of course, it’s fine to take your shot at a massive payout as well, but be sure to only risk money you’re prepared to lose.

If you’re into other bet types aside from parlays, feel free to check out some of our other weekly NFL betting content, which is listed below:


If you want to build your own parlays, every NFL game has dozens of markets and hundreds of individual betting options to choose from at sites such as DraftKings, BetMGM, and FanDuel, among others. If you’re looking for suggestions, check out our Week 6 NFL parlays after looking over the options at a few sites.

*odds are subject to change after writing*

Week 6 NFL Parlays | What The Sportsbooks Are Offering

If you aren’t into building out your own parlay, you can start by selecting from the options offered by the sportsbook. Once you dig into props, the number of betting options can be a bit overwhelming. If you want to stick to sides and totals, the sportsbook offers several pre-made parlay choices.

One way in which sites offer parlays is by combining several teams together, enhancing the odds of that wager, and putting it in the ‘Odds Bosts’ (or a similarly-named section) part of the site. But for each individual NFL contest, most sites also offer bettors the chance to link the moneyline or spread together with the total.

Think of this as a sort of same-game parlay, which we’ll get more into below, just without any of the props attached. Sometimes, correlating one side with the total in the same matchup can be easier than analyzing multiple football games.

Bills -3.5 & Over 53.5 (+200 at FanDuel): FanDuel offers eight variations of a spread/total parlay for every game on the schedule, and we found one for Monday Night Football in Week 6.

The Bills’ offense just dominated bad Kansas City defense, and Tennessee’s group is nearly as awful on that side of the ball. Buffalo will score at least four touchdowns in this game, and Ryan Tannehill will be playing catch-up. This pre-build FanDuel parlay helps us cover a key number of four (-3.5 is down from the current spread of -5.5) and we’re also able to shave a point off the current total and still get +200 for both.


Packers ML & Under 51.5 Points (+115 at BetMGM): BetMGM offers a massive range of moneyline/total and spread/total parlays for every single game, so you can get virtually any combination you can think of.

The Packers have won four games in a row and despite going on the road against a rival, we’re trusting this offense can overcome the injuries it has on defense by scoring enough on Chicago. The Bears will have a tough time with Davante Adams and the Packers’ red zone woes will see some positive regression.

When these two face off in Chicago, we mostly see low-scoring affairs. This total started around 47.5 and plunged to 44.5. We’re covering a few key numbers and taking the under. Combined, we’ll take +115 for two sides we’re comfortable with.


Week 6 NFL Same Game Parlay | Buccaneers vs. Eagles Picks

Same-game parlays are becoming much more popular and now, nearly every big sportsbook offers them. Bettors can combine game results (ML, spread, and totals) with game, team, and player props to create a larger bet that is entirely focused on one contest.

Below, we’ve combined the moneyline with an alternate total and several props to build an SGP for the Bucs vs. Eagles matchup on Thursday, which comes out to +1200 at DraftKings Sportsbook:

  • Philadelphia Eagles +7.5
  • Alternate Total Under 59.5
  • Antonio Brown Anytime TD
  • Zach Ertz 40+ Receiving Yards
  • Jalen Hurts Over 249.5 Passing Yards

Philadelphia is a home underdog catching more than a touchdown in this spot on a short week. Yes, the Bucs are a better team, especially on offense, but that’s what we have the touchdown for. Tampa Bay’s run defense is elite but its secondary is banged up and we think it will allow Jalen Hurts to throw with some success. We’ll take him to reach the 250-yard mark with at least 40 of those yards going to Zach Ertz now that Dallas Goedert is hurt.

This total is around 52.5 and even though prime-time games have been pretty high scoring, we’re going to take a chance this doesn’t get quite to 50. But when we look at Tampa Bay’s inevitable scoring drives, we’re taking a shot with Antonio Brown now that Chris Godwin joins Rob Gronkowski on the sidelines. In total, this parlay goes for 12x your investment.

NFL Week 6 Parlays | Betting The Favorites

One consistently popular NFL parlay strategy is to link several favorable lines into the same bet. The goal is to build a safer wager while enhancing the payout, even though the odds aren’t astronomical like we see with some parlays.

This could include alternate spreads and totals, or moneylines for larger favorites. This week, we’re getting +164 odds at FanDuel Sportsbook for the following:

  • Chiefs/Washington Over 47
  • Dallas Cowboys ML
  • Indianapolis Colts ML

The Chiefs and Washington are two teams having success on offense while also playing terrible defense. For the WFT, that comes as a bit of a surprise, but it won’t be turning around in Week 6. Kansas City looks like the league’s worst defensive unit and considering that the WFT has hit 30+ on multiple occasions so far, we like this over pulled down about a touchdown from where it sits now.

Dallas is the riskiest part of this bet as 3.5-point favorites on the road. It’s a sell-high spot on a Cowboys team that could be due for a bit of regression. That said, we trust this offense enough to score after seeing Houston outsmart the New England defense a little bit. Dallas actually has a top 10 defense according to DVOA data to go with its top-five offense, so we’re rolling with the Cowboys.

The Colts are 1-4 just like the Texans are, but Indy is certainly better than the record shows. This will be a desperate team at home and one that is unlikely to fall for the same kind of tricks on defense now that they’re on tape against New England. Indianapolis may not cover the spread but it should win the game with ease.

Week 6 NFL Betting Odds

Brian Sausa Avatar
Written by
Brian Sausa

Brian Sausa is a longtime sports writer with extensive betting experience and knowledge of the industry. A journalism graduate with an extensive sports background, Brian has been employed by multiple professional leagues including MLB, MiLB (Minor League Baseball), and the NHL.

View all posts by Brian Sausa
Privacy Policy