DraftKings.com NFL DFS Week 10 Picks and Plays for Cash Game and GPP Lineups

Week 10 of NFL DFS is upon us, and everyone is looking to cash in on the big daily fantasy football money at DraftKings. Every week, we’ll bring you our top NFL DFS picks at each position, separating them into Cash Game and GPP plays. And to keep up with all things PlayPicks, follow us on Twitter and like us on Facebook.

As with any daily fantasy sport, the advice below is relevant for fantasy purposes. A player or team might be better or worse from a fantasy perspective than in real life due to matchup, price, gameflow, and various other factors. This is important to remember when constructing a roster.

In DFS NFL, predicting gameflow can be vital. For example, teams winning comfortably are far more likely to lean on their running games, while two teams with poor defenses and high-powered offenses could pay off by getting into a shootout. Later in the season, weather will play a key factor in NFL games, so make sure to check the forecast for each Sunday.

And if you’re looking for a new way to play DFS, give DRAFT Fantasy a try with our exclusive promo code and get a free $3 entry.

Best Week 10 NFL DFS Quarterback Plays

Matthew Stafford vs. CLE ($6.8K) – Cash
After crushing the Green Bay Packers en route to 361 yards and two touchdowns, Matthew Stafford gets an even better matchup this week against the lowly Cleveland Browns, a team whose defense ranks 26th in DVOA vs. the pass. They are good against the run (second in DVOA), which makes me think Detroit will really struggle to establish any sort of ground game. I actually think that makes things much harder on Stafford, but he should be able to overcome gameflow issues en route to 300 yards and/or a few scores.

Jared Goff vs. HOU ($6.7K DraftKings) – GPP
Jared Goff absolutely torched the New York Giants last week with 311 yards and four touchdowns on just 22 passing attempts. This week, he faces a Houston team that just allowed Jacoby Brissett and T.Y. Hilton to connect for 175 yards and two scores (Brissett 308 pass yards for the game). Goff has plenty of big-play threats in Todd Gurley and Sammy Watkins, but I think the former will struggle on the ground, as Houston ranks sixth in DVOA against the run. Still, the Rams boast an implied total of more than 28. The spread and O/U anticipate plenty of scoring from Los Angeles, and I expect the Rams to hit Houston where they’re weakest — the passing game.

Ryan Fitzpatrick vs. NYJ ($4.9K) – GPP
This is probably my favorite quarterback play of the week. Ryan Fitzpatrick is a veteran journeyman who rarely ever has anything to play for, as he’s never played in a playoff game. Now, with Jameis Winston out, Fitzpatrick faces off against his former team, the New York Jets. With that narrative working in his favor, coupled with the fact that the Jets are 24th in DVOA vs. the pass, you’ve got yourself a very cheap veteran quarterback to spend up elsewhere. Last week, “Fitz’ showed that he still has it (somewhat), with eight completions for 68 yards and a touchdown after replacing Winston. It should be noted Mike Evans will be out this week, which does limit Fitzpatrick’s ceiling. I think he’s a bit shaky in Cash (though his salary gives him such a low barrier to hitting value), but I really love him in tournaments.

Josh McCown @ TB ($6.1K DraftKings) – Cash
From one journeyman veteran to another, Josh McCown is also facing a former team of his in Tampa Bay. The Jets are bad against opposing passers, but the Buccaneers are even worse, ranking 31st in DVOA vs. the pass. While McCown is a whopping $6.1K (which seems very high considering his limited upside), the matchup makes him safe. I don’t like him in GPPs at all for the reasons I just listed, but he’s a good pivot off Ben Roethlisberger, and maybe even Matt Ryan, in Cash lineups. After all, McCown hasn’t scored fewer than 16.9 DK points in any of his last four games, even though the Jets lost three of them.

Secondary Options: Dak Prescott, Ben Roethlisberger, Matt Ryan, Marcus Mariota, Tyrod Taylor

Best Week 10 NFL DFS Running Back Plays

Jordan Howard vs. GB ($6.1K DraftKings – GPP/Cash
I liked Jordan Howard last week, and I like him again this week. The Bears’ lead back is coming off an 18.1 DK-point week against New Orleans last week, and he continues to serve as their only real offensive threat. His 23 carries and five targets last week just further prove that.

While the Bears came up short against the Saints, it’s abundantly clear they want to control the game via the run. Coupled with their underrated defense, the Bears rushing offense has kept them competitive at times this year. This week, Howard get a floundering Green Bay team. They also rank 24th in DVOA against the run and allowed Howard to rush for 54 yards in a score at home earlier this season.

Melvin Gordon @ JAX ($7.2K DraftKings) – GPP
The Jaguars really do have a tremendous defense, and there’s honestly not much to like on the Chargers’ side of things. That said, Melvin Gordon stands out as a high upside guy who should be the focal point of the Chargers’ offense this week. To begin with, Jacksonville ranks first in DVOA overall, but they are dead last against the run, allowing the most yards per carry in the NFL. Second, this game is projected to be a low-scoring affair, which could lead to a lot of work on the ground for both sides. I expect Fournette to be extremely chalky this week, but Gordon has appeal, as Jacksonville isn’t great against the run, and he’s basically the only path to victory for the 3-5 Chargers.

Devonta Freeman vs. DAL ($6.0K DraftKings) – Cash/GPP
The Falcons’ lead back is just barely that, still very much in a timeshare with Tevin Coleman. That said, he faces a Dallas Cowboys defense that ranks third-to-last in DVOA against the run. As the early-down back, Devonta Freeman should see plenty of work as the Falcons work to set up the play-action in a game carrying an over/under of 50.5, the highest of the week.

Freeman has disappointed as of late, failing to break 12 DK points in the past four weeks. However, that should drive down his ownership. He’s also seen his rushing workload decrease, but his targets have increased. I think both of those trends have more to do with the lengthy road trip, and I believe this gameflow against the Cowboys at home will be much, much more favorable for Freeman.

Orleans Darkwa @ SF ($4.5K DraftKings) – GPP
With a decimated receiving corp and a disaster of a season in general, the New York Giants’ lead back is somehow Orleans Darkwa. He led the team in yards from scrimmage last week. The running back rushed the ball 16 times for 71 yards and added eight more yards on two receptions. Against a 49ers defense that has allowed the most total touchdowns to opposing running backs, including six on the ground, I expect Darkwa to make the most of a workload in the mid- to high teens.

Secondary Options: Le’Veon Bell, Lamar Miller, Whatever Cowboys Running Back Plays, Matt Forte, Leonard Fournette, LeSean McCoy

Stay on top of all the news by following us on Twitter and liking us on Facebook

Best Week 10 NFL DFS Wide Receiver Plays

Adam Humphries vs. NYJ ($3.1K DraftKings) – GPP
With Mike Evans out this week, the Buccaneers’ offense is without their top weapon. Jameis Winston is also out, meaning there is plenty of opportunity to go around. While Ryan Fitzpatrick is a definitive downgrade, I much prefer him to a battered Winston. Also, Evans is averaging over nine targets per game this season. While I expect the Bucs to throw less than usual, I still think Adam Humphries could see a few more targets than normal. At just $3.1K “a few more targets” could be enough to get Humphries into 5x’ing his salary. Again, the Jets are 24th in DVOA vs. the pass, and Humphries will never be cheaper than this.

Robert Woods vs. HOU ($5.0K DraftKings) – GPP/Cash
Sammy Watkins has name value and big-play potential, but Robert Woods at least has the latter, coming off a week in which he scored two touchdowns. You’ll be tempted to go down $200 to get Watkins instead, but I really like Woods as the top receiver on the Los Angeles Rams this week. First of all, Kareem Jackson is extremely exploitable, and Houston’s defense has suffered against the big play as a result (just look at what T.Y. Hilton did to them last week). Second, Jonathan Joseph should spend most of his afternoon covering Watkins, and he’s really the only good coverage back in Houston. And finally, Houston is excellent against the run, as stated before. I expect Goff to throw, and Woods will have the most opportunities to come up big.

Marqise Lee vs. LAC ($4.1K DraftKings) – GPP
Coming off a 12-target, eight-reception, one-touchdown showing last week, Lee appears to be Blake Bortles’ top option of the remaining receiving corp. While Leonard Fournette will return this week, Chris Ivory rushed the ball 20 times last week, so it isn’t as if Jacksonville went super pass-heavy without their lead back. Also, Jacksonville will enter into this matchup as home favorites against a Chargers team that has actually had more success on the road (2-2) than at home (1-3) this season. While the Jaguars will likely lean into the run more with Fournette, I am very concerned about his having not played since Oct. 15. Fournette should see 20+ touches regardless of efficiency, but the Jags will likely throw at least 35 times. As the clear-cut receiving option a week ago, I’m doubling down on Lee, who is still walking around with just a $4.1K price tag. I’m always interested in a receiver who is going to potentially lead his team in targets at this price point.

Antonio Brown @ IND ($9.5K DraftKings) – Cash/GPP
Coming off a bye week, the Pittsburgh Steelers get a bad Colts team that has been dominated by the likes of the Jaguars and Titans. Though I’m not thrilled about relying on Ben Roethlisberger on the road, the Colts really are a bad defensive unit, 29th in DVOA. They also rank 30th in DVOA specifically against the pass. Antonio Brown is an elite wideout who has disappointed rather frequently this season, perhaps a result of the tensions in Pittsburgh. But following an extra week for Mike Tomlin to prepare and get his team back on track, this has all the makings for a huge Brown performance.

Secondary Options: Jermaine Kearse, Mohamed Sanu, Corey Davis, Juju Smith-Schuster, DeSean Jackson

Best Week 10 NFL DFS Tight End Plays

Garrett Celek vs. NYG ($2.5K DraftKings) – Cash/GPP
While Garrett Celek is a bit risky as a Cash play, I think he’s viable. He’s certainly viable in GPPs where he carries very strong upside at his price point. I’m about to go into how much I like Evan Engram (even at $6.2K), but I think the other top option you have on this slate is to go really cheap with Celek, who is replacing an injured George Kittle this week. The Giants are 21st in DVOA vs. TE, and Celek has to do very little to hit value. I like him in Cash, but I love him in tournaments.

Evan Engram @ SF ($6.2K DraftKings) – GPP/Cash
I’ll admit I missed on Engram last week, when I thought he would struggle against a Los Angeles Rams defense that is quite good at shutting down TEs (fourth in DVOA vs. that position). But he came through for those who rostered him, scoring 17 DK points. This week, he gets a San Francisco defense ranked third in DVOA vs. TE. I’m not going to let this matchup scare me off Engram again, as he has caught a touchdown in each of his last three games and drawn 22 targets in his last two outings. There’s just not much else for Eli Manning.

Secondary Options: Cameron Brate, Kyle Rudolph, Jack Doyle

Best Week 10 NFL DFS Defense Plays

Chicago Bears vs. GB ($3.0K DraftKings) – Cash/GPP
The Packers just can’t get much going in the passing game without Aaron Rodgers. Brett Hundley hasn’t quite figured it out yet, with just one touchdown vs. four interceptions and two fumbles. The Bears held Drew Brees and the Saints to just 20 points last week at the Superdome and Cam Newton and the Panthers to three points the week prior. It’s time to push the chips in on this Chicago defense.

Detroit Lions vs. CLE ($3.8K DraftKings) – Cash
Against a terrible Browns offense, the Detroit Lions D/ST carries a very high ceiling, as well as arguably the highest floor on the slate. Detroit currently carries an implied total of 28 with a spread of -12. Cleveland will really struggle getting anything going in this one, as the Lions rank 7th in DVOA, so I’m firing them up in Cash and GPP. However, I will not be pairing Lions D/ST and Stafford in GPPs.

Secondary Options: Houston Texans, Washington Redskins

Use our DRAFT promo code for a free $3 entry and new way to play DFS!